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Biomarker development and clinical application by extraction of pathogenesis-related factors from early fibrosis foci of interstitial pneumonia

Research Project

Project/Area Number 17K09630
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNippon Medical School

Principal Investigator

Terasaki Yasuhiro  日本医科大学, 医学部, 准教授 (50332870)

Co-Investigator(Kenkyū-buntansha) 寺崎 美佳  日本医科大学, 医学部, 講師 (50372785)
渡辺 憲太朗  福岡大学, 医学部, 教授 (80158625)
三宅 弘一  日本医科大学, 医学部, 教授 (90267211)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords早期線維化巣 / UIP / COP / PPFE / 弾性線維新生 / 瘢痕性器質化肺炎 / 骨髄移植関連肺病変 / OP / 骨化 / 疾患マーカー / RAS / バイオマーカー開発 / 間質性肺炎
Outline of Final Research Achievements

In the PPFE case, the elastic fibers of the alveolar septum remained, and newly formed elastic fibers were seen in the active fibrous lesion.In UIP cases, the elastic fibers in the alveolar septum tended to disappear, and cysts with fibrous remodeling with bronchiolization were formed, but there was no evidence of newly formed elastic fibers in the active fibrous lesion.Mass spectrometry analysis revealed increased levels of FBLN and LTBP2 iin the active fibrous lesion of PPFE, and immunostaining showed FBLN- and LTBP2-positive newly formed elastic fibers were often seen in the active fibrous lesion of PPPFE cases. FBLN levels in serum of 4 PPFE cases, 4 UIP cases, and 4 controls were very high only in PPFE cases, indicating its potential as a marker of hematologic disease in PPFE lesions.

Academic Significance and Societal Importance of the Research Achievements

臨床ヒト検体である間質性肺炎の早期線維化巣に注目し、病理形態から分子生物学的手法を駆使した解析によって病態関連因子を抽出する手法であるため、ヒト血清で測定可能なバイオマーカーの開発として可能性が高く現実的であり、比較的早期の臨床応用が期待される。また臨床検体由来として抽出された関連因子を中心とした治療実験を行うので、効果を含めた肺線維化の病態解析は、臨床での間質性肺炎での治療応用へ発展性の高い研究になると考えられる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (48 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (32 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 32 results,  Open Access: 10 results,  Acknowledgement Compliant: 4 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (8 results)

  • [Journal Article] Noninvasive monitoring of allograft rejection in a rat lung transplant model: Application of machine learning-based 18F-fluorodeoxyglucose positron emission tomography radiomics2022

    • Author(s)
      Tian Dong、Shiiya Haruhiko、Takahashi Miwako、Terasaki Yasuhiro、Urushiyama Hirokazu、Shinozaki-Ushiku Aya、Yan Hao-Ji、Sato Masaaki、Nakajima Jun
    • Journal Title

      The Journal of Heart and Lung Transplantation

      Volume: - Issue: 6 Pages: 722-731

    • DOI

      10.1016/j.healun.2022.03.010

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful Treatment with Afatinib after Osimertinib-induced Interstitial Lung Disease in a Patient with EGFR-mutant Non-small-cell Lung Cancer2021

    • Author(s)
      Nishima Shunichi、Miyanaga Akihiko、Saito Sho、Yuasa Mizuki、Takahashi Satoshi、Kashiwada Takeru、Sugano Teppei、Noro Rintaro、Minegishi Yuji、Terasaki Yasuhiro、Saito Yoshinobu、Kubota Kaoru、Seike Masahiro、Gemma Akihiko
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 4 Pages: 591-594

    • DOI

      10.2169/internalmedicine.5435-20

    • NAID

      130007986415

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-02-15
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protective Effects of Hydrogen against Irradiation2021

    • Author(s)
      Terasaki Yasuhiro、Terasaki Mika、Shimizu Akira
    • Journal Title

      Current Pharmaceutical Design

      Volume: 27 Issue: 5 Pages: 679-686

    • DOI

      10.2174/1381612827666210119103545

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury2021

    • Author(s)
      Aokage Toshiyuki、Seya Mizuki、Hirayama Takahiro、Nojima Tsuyoshi、Iketani Masumi、Ishikawa Michiko、Terasaki Yasuhiro、Taniguchi Akihiko、Miyahara Nobuaki、Nakao Atsunori、Ohsawa Ikuroh、Naito Hiromichi
    • Journal Title

      BMC Pulmonary Medicine

      Volume: 21 Issue: 1 Pages: 339-339

    • DOI

      10.1186/s12890-021-01712-2

    • NAID

      120007170516

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics of immunoglobulin G<sub>4</sub>-positive interstitial pneumonia2021

    • Author(s)
      Komatsu Masamichi、Yamamoto Hiroshi、Matsui Shoko、Terasaki Yasuhiro、Hebisawa Akira、Iwasawa Tae、Johkoh Takeshi、Baba Tomohisa、Miyamoto Atsushi、Handa Tomohiro、Tomii Keisuke、Waseda Yuko、Bando Masashi、Ishii Haruyuki、Miyazaki Yasunari、Yoshizawa Akihiko、Takemura Tamiko、Kawabata Yoshinori、Ogura Takashi
    • Journal Title

      ERJ Open Research

      Volume: 7 Issue: 3 Pages: 00317-2021

    • DOI

      10.1183/23120541.00317-2021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Malignant pleural mesothelioma with heterologous elements2021

    • Author(s)
      Kawai Toshiaki、Seki Reishi、Miyajima Kuniharu、Nakashima Hiroshi、Takeda Takayuki、Murakami Tomoyuki、Aoe Keisuke、Okabe Kazunori、Homma Keiichi、Tsukamoto Yoshitane、Sunada Koichi、Terasaki Yasuhiro、Iida Maki、Orikasa Hideki、Hiroshima Kenzo
    • Journal Title

      Journal of Clinical Pathology

      Volume: - Issue: 10 Pages: 690-695

    • DOI

      10.1136/jclinpath-2021-207575

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LPS-induced airway-centered inflammation leading to BOS-like airway remodeling distinct from RAS-like fibrosis in rat lung transplantation2020

    • Author(s)
      Takahagi Akihiro、Sato Masaaki、Chen-Yoshikawa Toyofumi F、Miyamoto Ei、Saito Masao、Gochi Fumiaki、Hamaji Masatsugu、Yoshizawa Akihiko、Terasaki Yasuhiro、Urushiyama Hirokazu、Aoyama Akihiro、Sonobe Makoto、Date Hiroshi
    • Journal Title

      Transplantation

      Volume: - Issue: 6 Pages: 1-1

    • DOI

      10.1097/tp.0000000000003097

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epithelial Expression of YAP and TAZ Is Sequentially Required in Lung Development2020

    • Author(s)
      Isago Hideaki、Mitani Akihisa、Mikami Yu、Horie Masafumi、Urushiyama Hirokazu、Hamamoto Ryuji、Terasaki Yasuhiro、Nagase Takahide
    • Journal Title

      American Journal of Respiratory Cell and Molecular Biology

      Volume: 62 Issue: 2 Pages: 256-266

    • DOI

      10.1165/rcmb.2019-0218oc

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Crosstalk Between TGF-β and Periostin Can Be Targeted for Pulmonary Fibrosis.2020

    • Author(s)
      Nanri Y, Nunomura S, Terasaki Y, Yoshihara T, Hirano Y, Yokosaki Y, Yamaguchi Y, Feghali- Bostwick C, Ajito K, Murakami S, Conway SJ, Izuhara K.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 62 Issue: 2 Pages: 204-216

    • DOI

      10.1165/rcmb.2019-0245oc

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Organizing Pneumonia after Nivolumab Treatment in a Patient with Pathologically Proven Idiopathic Pulmonary Fibrosis2019

    • Author(s)
      Kashiwada T, Minegishi Y, Saito Y, Kato T, Atsumi K, Seike M, Kubota K, Terasaki Y, Gemma A.
    • Journal Title

      Journal of Nippon Medical School

      Volume: 86 Issue: 1 Pages: 43-47

    • DOI

      10.1272/jnms.JNMS.2019_86-8

    • NAID

      130007620530

    • ISSN
      1345-4676, 1347-3409
    • Year and Date
      2019-01-15
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Criteria for the diagnosis of idiopathic pleuroparenchymal fibroelastosis: A proposal.2019

    • Author(s)
      Watanabe K, Ishii H, Kiyomi F, Terasaki Y, Hebisawa A, Kawabata Y, Johkoh T, Sakai F, Kondoh Y, Inoue Y, Azuma A, Suda T, Ogura T, Inase N, Homma S
    • Journal Title

      Respir Investig.

      Volume: 4 Issue: 4 Pages: 312-320

    • DOI

      10.1016/j.resinv.2019.02.007

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion.2019

    • Author(s)
      Fujisawa T, Mori K, Mikamo M, Ohno T, Kataoka K, Sugimoto C, Kitamura H, Enomoto N, Egashira R, Sumikawa H, Iwasawa T, Matsushita S, Sugiura H, Hashisako M, Tanaka T, Terasaki Y, Kunugi S, Kitani M, Okuda R, Horiike Y, Enomoto Y, Yasui H, Hozumi H, Suzuki Y, Nakamura Y, Fukuoka J, Johkoh T, Kondoh Y, Ogura T,,, Suda T.
    • Journal Title

      Eur Respir J.

      Volume: 3 Issue: 5 Pages: 1802243-1802243

    • DOI

      10.1183/13993003.02243-2018

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of rapamycin inhibitor-induced lung disease.2019

    • Author(s)
      Kokuho N, Terasaki Y, Kunugi S, Saito Y, Urushiyama H, Terasaki M, Hayashi H, Gemma A, Shimizu A.
    • Journal Title

      Laboratory Investigation

      Volume: 2 Issue: 6 Pages: 853-865

    • DOI

      10.1038/s41374-018-0158-9

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation.2019

    • Author(s)
      Terasaki Y, Suzuki T, Tonaki K, Terasaki M, Kuwahara N, Ohsiro J, Iketani M, Takahashi M, Hamanoue M, Kajimoto Y, Hattori S, Kawaguchi H, Shimizu A, Ohsawa I.
    • Journal Title

      Laboratory Investigation

      Volume: 2 Issue: 6 Pages: 793-806

    • DOI

      10.1038/s41374-019-0187-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Naftopidil reduced the proliferation of lung fibroblasts and bleomycin-induced lung fibrosis in mice.2019

    • Author(s)
      Urushiyama H, Terasaki Y, Nagasaka S, Kokuho N, Endo Y, Terasaki M, Kunugi S, Makita K, Isago H, Hosoki K, Souma K, Ishii T, Matsuzaki H, Hiraishi Y, Mikami Y, Noguchi S, Tamiya H, Mitani A, Yamauchi Y, Shimizu A, Nagase T.
    • Journal Title

      J Cell Mol Med.

      Volume: 3 Issue: 5 Pages: 1-9

    • DOI

      10.1111/jcmm.14255

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cholix toxin, an eEF2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.2019

    • Author(s)
      Yahiro K, Ogura K, Terasaki Y, Satoh M, Miyagi S, Terasaki M, Yamasaki E, Moss J.
    • Journal Title

      Cell Microbiol.

      Volume: 4 Issue: 8

    • DOI

      10.1111/cmi.13033

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interstitial lung disease associated with nanoparticle albumin-bound paclitaxel treatment in patients with lung cancer.2019

    • Author(s)
      Kashiwada T, Saito Y, Terasaki Y, Hisakane K, Takeuchi S, Sugano T, Miyanaga A, Noro R, Minegishi Y, Seike M, Kubota K, Gemma A.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 1;49(2): Issue: 2 Pages: 165-173

    • DOI

      10.1093/jjco/hyy180

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-MDA5 antibody-positive rapidly progressive interstitial pneumonia without cutaneous manifestations.2019

    • Author(s)
      Aoyama J, Hayashi H, Yajima C, Takoi H, Tanaka T, Kashiwada T, Kokuho N, Terasaki Y, Nishikawa A, Gono T, Kuwana M, Saito Y, Abe S, Seike M, Gemma A.
    • Journal Title

      Respir Med Case Rep

      Volume: 14;26: Pages: 193-196

    • DOI

      10.1016/j.rmcr.2019.01.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spontaneous pulmonary hematoma with diffuse pulmonary ossification requiring emergency treatment: a case report.2019

    • Author(s)
      Sonokawa T, Matsui T, Takegahara K, Inoue T, Kashiwada T, Terasaki Y, Usuda J.
    • Journal Title

      Surg Case Rep.

      Volume: 18;5(1):27. Issue: 1

    • DOI

      10.1186/s40792-019-0589-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathologic glomerular characteristics and glomerular basement membrane alterations in biopsy-proven thin basement membrane nephropathy.2019

    • Author(s)
      Kajimoto Y, Endo Y, Terasaki M, Kunugi S, Igarashi T, Mii A, Terasaki Y, Shimizu A.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 23(5) Issue: 5 Pages: 638-649

    • DOI

      10.1007/s10157-018-01687-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.2018

    • Author(s)
      Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T
    • Journal Title

      Respiratory Medicine

      Volume: 141 Pages: 190-197

    • DOI

      10.1016/j.rmed.2018.06.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A sarcomatoid localized malignant mesothelioma with ostesarcomatous elements2018

    • Author(s)
      Terasaki M, Terasaki Y, Takahashi M, Kokuho N, Kunugi S, Usuda J, Shimizu A.
    • Journal Title

      Human Pathology,Case Reports

      Volume: 14 Pages: 16

    • DOI

      10.1016/j.ehpc.2018.06.003

    • URL

      https://pure.teikyo.jp/en/publications/ec990698-9a18-43c7-83ed-a26655d1a61a

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Favorable Response to Levetiracetam in a Patient with Metastatic Adenoid Cystic Carcinoma2018

    • Author(s)
      Sakata Shinya、Saeki Sho、Terasaki Yasuhiro、Natori Yoshihiro、Fujii Kazuhiko
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 5 Pages: 721-724

    • DOI

      10.2169/internalmedicine.9300-17

    • NAID

      130006407688

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Endometrioid carcinoma arising in a uterine adenomyoma2018

    • Author(s)
      Terasaki M, Terasaki Y, Kawase R, Shimizu A.
    • Journal Title

      Human Pathology: Case Reports

      Volume: 13 Pages: 24-26

    • DOI

      10.1016/j.ehpc.2018.04.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapidly Progressive Multiple Digital Gangrene and Diffuse Alveolar Damage in a Patient With Antisynthetase Antibody and Gastric Cancer.2018

    • Author(s)
      Fukue R, Gono T, Hayashi H, Terasaki Y, Kuwana M.
    • Journal Title

      J Clin Rheumatol.

      Volume: 12 Issue: 8S Pages: S585-S589

    • DOI

      10.1097/rhu.0000000000000974

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elotuzumab-induced interstitial lung disease: the first case report.2018

    • Author(s)
      Tanaka T, Saito Y, Kokuho N, Tamura H, Terasaki Y, Seike M, Gemma A.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 1;48(5) Issue: 5 Pages: 491-494

    • DOI

      10.1093/jjco/hyy049

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of interstitial lung disease with alveolar hemorrhage induced by pembrolizumab.2018

    • Author(s)
      Sugano T, Seike M, Noro R, Kaburaki S, Tozuka T, Takahashi A, Takano N, Tanaka T, Kashiwada T, Takeuchi S, Minegishi Y, Saito Y, Kubota K, Terasaki Y, Gemma A.
    • Journal Title

      Onco Targets Ther. 2

      Volume: 17;11 Pages: 5879-5883

    • DOI

      10.2147/ott.s169321

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimal conditions and the advantages of using laser microdissection and liquid chromatography tandem mass spectrometry for diagnosing renal amyloidosis2018

    • Author(s)
      Aoki Michiko、Kang Dedong、Katayama Akira、Kuwahara Naomi、Nagasaka Shinya、Endo Yoko、Terasaki Mika、Kunugi Shinobu、Terasaki Yasuhiro、Shimizu Akira
    • Journal Title

      Clin Exp Nephrol

      Volume: 25 Issue: 4 Pages: 871-880

    • DOI

      10.1007/s10157-018-1533-y

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of clinical and pathological features of lung lesions of systemic IgG4-related disease and idiopathic multicentric Castleman's disease2017

    • Author(s)
      Terasaki Y, Ikushima S, Hebisawa A, Ichimura Y, Izumi S, Ujita M, Arita M et al.
    • Journal Title

      Histopathology

      Volume: 印刷中 Issue: 7 Pages: 1114-1124

    • DOI

      10.1111/his.13186

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucaosa-associated lymphoid tissue lymphoma presenting with multiple mass lesion.2017

    • Author(s)
      Kokuho N, Terasaki Y, Kunugi S, Onda N, Urushiyama H, Terasaki M, Hino M, Gemma A, Hatori T, Shimizu A.
    • Journal Title

      Human Pathology

      Volume: 印刷中 Pages: 180-186

    • DOI

      10.1016/j.humpath.2016.10.028

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts.2017

    • Author(s)
      Noguchi S, Saito A, Mikami Y, Urushiyama H, Horie M, Matsuzaki H, Takeshima H, Makita K, Miyashita N, Mitani A, Jo T, Yamauchi Y, Terasaki Y, Nagase T.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 42595-42595

    • DOI

      10.1038/srep42595

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Vibrio cholerae Cholix toxin-induced HepG2 cell death is enhanced by tumor necrosis factor-alpha through ROS and intracellular signal-regulated kinases2017

    • Author(s)
      1.Ogura K, Terasaki Y, Miyoshi-Akiyama T, Terasaki M, Moss J, Noda M, Yahiro K.
    • Journal Title

      Toxicological Science

      Volume: 156 Pages: 455468-455468

    • DOI

      10.1093/toxsci/kfx009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 特発性びまん性肺骨化症の臨床病理学的検討2021

    • Author(s)
      寺崎, 泰弘
    • Organizer
      日本病理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 当院における抗OJ抗体陽性の間質性肺炎における気管支鏡検査に関する検討2021

    • Author(s)
      芳賀三四郎1・田中  徹1・柏田  建1・齋藤 好信1 湯浅 瑞希1・青山 純一1・田中 庸介1・功刀しのぶ2 寺崎 泰弘2・藤田 和恵1・久保田 馨い清家 正博1 弦間 昭彦1
    • Organizer
      第44回日本呼吸器内視鏡学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Pathological features of lung lesions in PPFE of idiopathic or transplantation related cases with evaluation of the elastic fiber related conditions comparing to those of IPF/UIP2019

    • Author(s)
      Yasuhiro Terasaki
    • Organizer
      ERS international congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] IgG4 関連肺疾患と鑑別疾患の病理所見2019

    • Author(s)
      寺崎 泰弘
    • Organizer
      第38回日本画像医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Study of Pathological Features of Lung Lesions in PPFE of Idiopathic or Transplantation Related Cases with Evaluation of the Elastic Fiber Related Conditions Comparing to Those of IPF/UIP2018

    • Author(s)
      Yasuhiro Terasaki, Nariaki Kokuho, MIka Terasaki, Shinobu Kunugi, Tsunekazu Hishima, Takashi Kijima, Kiyoshi Hashimoto, Yasuhiko Nishioka, Akira Shimizu
    • Organizer
      American Thoracic Society International Conference
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The analyses of immunoglobulin crystal formation at lung in crystal storing histiosytosis and crystalglobulinemia syndrome.2018

    • Author(s)
      Yasuhiro Terasaki, MD, PhD; Nariaki Kokuho, MD, PhD; Shinobu Kunugi, MD, PhD; Yusuke Kajimoto, MD; MikaTerasaki, MD, PhD, Akihiko Gemma, MD, PhD, Akira ShimizuMD, PhD
    • Organizer
      American Thoracic Society International Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pathological features of PPFE with evaluation of elastic fiber related conditions comparing to UIP.2018

    • Author(s)
      Yasuhiro Terasaki1, N Kokuho1, S Kunugi1, M Terasaki1, Yusuke Kigimoto1, T. Hishima2, Y. Aono3, Y. Nishioka4, T. Kijima5, K. Hashimoto6, K. Tomii7, S Watanabe8, T Kinoshita9, A Shiraki10, Y Nakamura11, M Satou12, A. Shimizu1
    • Organizer
      日本病理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] リンパ増殖性肺疾患2018

    • Author(s)
      寺﨑 泰弘
    • Organizer
      日本病理学会秋期総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 非腫瘍性疾患病理アトラス 肺  PPFE2022

    • Author(s)
      梶本雄介・寺﨑泰弘
    • Total Pages
      5
    • Publisher
      文光堂
    • ISBN
      9784830604867
    • Related Report
      2021 Annual Research Report
  • [Book] 非腫瘍性疾患病理アトラス 肺  肺骨化症2022

    • Author(s)
      梶本雄介・寺﨑泰弘
    • Total Pages
      5
    • Publisher
      文光堂
    • ISBN
      9784830604867
    • Related Report
      2021 Annual Research Report
  • [Book] 非腫瘍性疾患病理アトラス 肺  アミロイドーシス・軽鎖沈着症2022

    • Author(s)
      梶本雄介・寺﨑泰弘
    • Total Pages
      6
    • Publisher
      文光堂
    • ISBN
      9784830604867
    • Related Report
      2021 Annual Research Report
  • [Book] 非腫瘍性疾患病理アトラス 肺  IgG4関連肺疾患2022

    • Author(s)
      寺﨑泰弘
    • Total Pages
      7
    • Publisher
      文光堂
    • ISBN
      9784830604867
    • Related Report
      2021 Annual Research Report
  • [Book] 非腫瘍性疾患病理アトラス  肺  MCD2022

    • Author(s)
      寺﨑泰弘
    • Total Pages
      6
    • Publisher
      文光堂
    • ISBN
      9784830604867
    • Related Report
      2021 Annual Research Report
  • [Book] 呼吸器病変 病理 臨床医必読 最新IgG4関連疾患 改訂第2版2019

    • Author(s)
      寺崎泰弘
    • Total Pages
      240
    • Publisher
      診断と治療社
    • ISBN
      9784787824394
    • Related Report
      2019 Research-status Report
  • [Book] 間質性肺疾患診療マニュアル改訂第 3 版 II 間質性肺疾患の診断・検査一画像と病理がわかる C. 病理組織の見方2019

    • Author(s)
      寺﨑泰弘
    • Publisher
      南江堂
    • Related Report
      2018 Research-status Report
  • [Book] Drug-Induced Lung Injury Pathology of DLI: What Is the Pathological Significance of DLI?2017

    • Author(s)
      Yasuhiro Terasaki, Yuh Fukuda
    • Publisher
      Springer Singapore Editors
    • ISBN
      9789811044656
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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