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New biomarkers of acute exacerbation in idiopathic interstitial pneumonias

Research Project

Project/Area Number 17K09636
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNHO Kinki Chuo Chest Medical Center(Clinical Research Center)

Principal Investigator

Arai Toru  独立行政法人国立病院機構近畿中央呼吸器センター, 臨床研究センター, 呼吸不全研究部長 (00537772)

Co-Investigator(Kenkyū-buntansha) 松室 昭子  独立行政法人国立病院機構近畿中央呼吸器センター, その他部局等, その他 (00470196)
井上 義一  独立行政法人国立病院機構近畿中央呼吸器センター, 臨床研究センター, 臨床研究センター長 (90240895)
広瀬 雅樹  独立行政法人国立病院機構近畿中央呼吸器センター, 臨床研究センター, 流動研究員 (90470195)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords間質性肺炎 / 急性増悪 / 予後因子 / サイトカイン / 特発性肺線維症 / 特発性間質性肺炎 / PDGF / RANTES / 予後予測 / 発症予測 / バイオマーカー / 予測因子 / トロンボモジュリン / 医学 / 呼吸器学 / 間質性肺疾患
Outline of Final Research Achievements

Acute exacerbation in idiopathic interstitial pneumonia (IIP) including idiopathic pulmonary fibrosis (IPF) is poor prognostic disorder. The most important cytokine predicting prognosis and occurrence of acute exacerbation in IPF was platelet-derived growth factor (PDGF). Our study also revealed that lower serum RANTES at the onset of acute exacerbation, and higher serum IL-10 7 days after the onset of acute exacerbation can predict poor survival of acute exacerbation.

Academic Significance and Societal Importance of the Research Achievements

IPFや、IIPの急性増悪の発症や予後の予測に有用なサイトカインは、これらの疾患、病態における、そのサイトカインの意義を示すと考えられる。したがって、PDGFを抑えることはIPFの予後を改善する可能性がある。また、RANTESは創傷の治癒に働くサイトカインであり、この低値は創傷治癒を遅らせ、予後不良に繋がる可能性がある。これらの知見が、新たな治療戦略、治療薬に繋がる可能性があると考える。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (27 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (15 results) (of which Int'l Joint Research: 4 results) Book (2 results)

  • [Journal Article] Platelet-derived growth factor can predict survival and acute exacerbation in patients with idiopathic pulmonary fibrosis2022

    • Author(s)
      Toru Arai, Masaki Hirose, Tomoko Kagawa, Kazuyoshi Matsuda, Yoshikazu Inoue
    • Journal Title

      Journal of Thoracic Disease

      Volume: 14(2) Issue: 2 Pages: 278-294

    • DOI

      10.21037/jtd-21-1418

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-Myxovirus Resistance Protein-1 Immunoglobulin A Autoantibody in Idiopathic Pulmonary Fibrosis2022

    • Author(s)
      Toru Arai , Masaki Hirose, Yoshimasa Hamano, Tomoko Kagawa, Akihiro Murakami, Hiroshi Kida, Atsushi Kumanogoh, Yoshikazu Inoue
    • Journal Title

      Canadian Respiratory Journal

      Volume: 2022 Pages: 1107673-1107673

    • DOI

      10.1155/2022/1107673

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage: Predictive Role for Acute Exacerbation of Idiopathic Interstitial Pneumonias2021

    • Author(s)
      Toru Arai, Tomoko Kagawa, Yumiko Sasaki, Reiko Sugawara, Chikatoshi Sugimoto, Kazunobu Tachibana, Yoshiki Fujita, Seiji Hayashi, Yoshikazu Inoue
    • Journal Title

      Canadian Respiratory Journal

      Volume: 2021 Pages: 4595019-4595019

    • DOI

      10.1155/2021/4595019

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of serum cytokines during acute exacerbation of idiopathic interstitial pneumonias treated with thrombomodulin2021

    • Author(s)
      Toru Arai , Hiroto Matsuoka, Masaki Hirose, Hiroshi Kida, Suguru Yamamoto, Yoshitaka Ogata, Masahide Mori, Kazuyoshi Hatsuda, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira,
    • Journal Title

      BMJ Open Respiratory Research

      Volume: 8 Issue: 1 Pages: e000889-e000889

    • DOI

      10.1136/bmjresp-2021-000889

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of recombinant thrombomodulin for poor prognostic cases of acute exacerbation in idiopathic interstitial pneumonia: secondary analysis of SETUP trial.2020

    • Author(s)
      Toru Arai, Hiroshi Kida, Yoshitaka Ogata, Satoshi Marumo, Hiroto Matsuoka, Iwao Gohma, Suguru Yamamoto, Masahide Mori, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira, Yoshikazu Inoue
    • Journal Title

      BMJ Open Respiratory Research

      Volume: 7 Issue: 1 Pages: 1-11

    • DOI

      10.1136/bmjresp-2020-000558

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is corticosteroid use truly not associated with improved outcomes in AE-IPF?2020

    • Author(s)
      Toru Arai, Yoshikazu Inoue
    • Journal Title

      Respirology

      Volume: 25 Issue: 6 Pages: 659-659

    • DOI

      10.1111/resp.13825

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pulmonary Veno-occlusive Disease: A Surgical Lung Biopsy-proven and Autopsied Case Radiologically Mimicking Hypersensitivity Pneumonitis at the Time of a Transbronchial Lung Biopsy2019

    • Author(s)
      Syojiro Minomo, Masanori Kitaichi, Toru Arai, Hideo Matsui, Masanori Akira, Yoshikazu Inoue
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 7 Pages: 955-964

    • DOI

      10.2169/internalmedicine.0681-17

    • NAID

      130007622178

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-04-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recombinant thrombomodulin for acute exacerbation in idiopathic interstitial pneumonias2019

    • Author(s)
      Toru Arai, Hiroshi Kida, Yoshitaka Ogata, Satoshi Marumo, Hiroto Matsuoka, Iwao Gohma, Suguru Yamamoto, Masahide Mori, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira, Ryuya Edahiro, Toshimitsu Hamasaki, Yoshikazu Inoue
    • Journal Title

      Respirology

      Volume: 印刷中 Issue: 7 Pages: 658-666

    • DOI

      10.1111/resp.13514

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticosteroids in acute exacerbation of idiopathic interstitial pneumonias: time to debate-Reply2018

    • Author(s)
      Toru Arai, Yoshikazu Inoue
    • Journal Title

      Respirology

      Volume: 23 Issue: 5 Pages: 546-547

    • DOI

      10.1111/resp.13278

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-dose prednisolone after intravenous methylprednisolone improves prognosis of acute exacerbation in idiopathic interstitial pneumonias2017

    • Author(s)
      Toru Arai, Kazunobu Tachibana, Chikatoshi Sugimoto, Yasushi Inoue, Sayoko Tokura, Okuma Tomohisa, Akia Masanori, Masanori Kitaichi, Seiji Hayashi, Yoshikazu Inoue
    • Journal Title

      Respirology

      Volume: 22 Issue: 7 Pages: 1363-1370

    • DOI

      10.1111/resp.13065

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 特発性間質性肺炎(IIP)急性増悪(AE)(AE-IIP)の血清サイトカイン動態と予後:SETUP試験探索的研究2021

    • Author(s)
      新井 徹,広瀬雅樹,初田和由,松岡洋人,緒方嘉隆,山本 傑,木田 博,杉本親寿,橘 和延,審良正則,井上義一
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 線維化関連サイトカイン低値はthrombomodulin治療を行った特発性間質性肺炎(IIP)急性増悪(AE) (AE-IIP)の90日死亡を示唆する2021

    • Author(s)
      新井 徹、広瀬雅樹、初田和由、橘 和延、井上義一
    • Organizer
      第75回国立病院総合医学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 特発性間質性肺炎(IIP)急性増悪(AE)(AE-IIP)の血清サイトカイン動態と予後:SETUP試験探索的研究2021

    • Author(s)
      新井徹
    • Organizer
      第61回日本呼吸器総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Efficacy of recombinant thrombomodulin for poor prognostic cases of acute exacerbation in IIPs: Secondary analysis of SETUP trial2019

    • Author(s)
      Toru Arai, Hiroshi Kida, Yoshitaka Ogata, Satoshi Marumo, Hiroto Matsuoka, Iwao Ghoma, Masahide Mori, Suguru Yamamoto, Kazunobu Tachibana, Chikatoshi Sugimoto, Masanori Akira, Yoshikazu Inoue
    • Organizer
      European Respiratory Society 2019 International Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 間質性肺疾患(ILD)の「急性増悪」に関する前向き観察と診断基準作成の試み NHOネットワーク研究第一報:発症急性期の予後規定因子2019

    • Author(s)
      新井 徹、杉本親寿、松井雪、広瀬雅樹、笠井孝彦、審良正則、井上義一
    • Organizer
      国立病院総合医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] プレドニゾロン(PSL)投与は特発性肺線維症(IPF)/possible UIPパターンの特発性間質性肺炎(IIPs)の急性増悪を増加させるか?2019

    • Author(s)
      新井徹、香川智子、菅原玲子、杉本親寿、橘和延、審良正則、林清二、井上義一
    • Organizer
      国立病院総合医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] プレドニゾロン投与は特発性肺線維症(IPF)/possible UIPパターンの特発性間質性肺炎(IIPs)の急性増悪を増加させるか?2019

    • Author(s)
      新井徹、杉本親寿、橘和延、井上康、杜倉紗代子、審良正則、笠井孝彦、北市正則、林清二、井上義一
    • Organizer
      日本呼吸器学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 特発性間質性肺炎(IIPs)の急性増悪(AE)(AE-IIPs)の重症度分類作成と高用量ステロイドの有用性の検証2019

    • Author(s)
      新井徹、杉本親寿、杜倉紗代子、竹内奈緒子、香川智子、井上康、橘和延、審良正則、林清二、井上義一
    • Organizer
      日本呼吸器学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Prognostic score of acute exacerbation (AE) in idiopathic interstitial pneumonias (IIPs) to evaluate treatment for AE-IIPs2019

    • Author(s)
      Toru Arai, Chikatoshi Sugimoto, Naoko Takeuchi, Yasushi Inoue, Kazunobu Tachibana, Tomohisa Okuma, Masanori Akira, Yoshikazu Inoue
    • Organizer
      American Thoracic Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性増悪時の血清マーカー増加率はHRCTパターンによる特発性間質性肺炎急性増悪の予後予測を改善する2018

    • Author(s)
      新井徹、杉本親寿、橘和延、井上康、杜倉紗代子、審良正則、笠井孝彦、北市正則、林清二、井上義一
    • Organizer
      国立病院総合医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 特発性間質性肺炎の急性増悪に対するthrombomodulinの有効性および安全性に関する前向き多施設共同試験(SETUP試験)2018

    • Author(s)
      新井徹、木田博、緒方嘉隆、丸毛聡、松岡洋人、郷間巌、山本傑、杉本親寿、橘和延、枝廣龍哉、濱﨑俊光、森雅秀、審良正則、井上義一
    • Organizer
      国立病院総合医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Combination of high-resolution computed tomography pattern and the changes of serum marker levels can predict survival of acute exacerbation in idiopathic interstitial pneumonias2018

    • Author(s)
      Toru Arai, Chikatoshi Sugimoto, Kazunobu Tachibana, Yasushi Inoue, Sayoko Tokura, Masanori Akira, Takahiko Kasai, Masanori Kitaichi, Seiji Hayashi, Yoshikazu Inoue
    • Organizer
      American Thoracic Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prednisolone really increases the frequency of acute exacerbation in IPF and IIPs with possible UIP HRCT pattern?2018

    • Author(s)
      Toru Arai, Tomoko Kagawa, Yumiko Sasaki, Reiko Sugawara, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Kitaichi, Masanori Akira, Seiji Hayashi, Yoshikazu Inoue
    • Organizer
      American Thoracic Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性増悪時の血清マーカー増加率はHRCTパターンによる特発性間質性肺炎急性増悪の予後予測を改善する2018

    • Author(s)
      新井徹、杉本親寿、橘和延、井上康、杜倉紗代子、審良正則、笠井孝彦、北市正則、林清二、井上義一
    • Organizer
      日本呼吸器学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 特発性間質性肺炎(IIPs)急性増悪の予測因子としてのBAL中ヘモジデリン貪食マクロファージ(HLMs)の意義2017

    • Author(s)
      新井徹、香川智子、佐々木由美子、菅原玲子、杉本親寿、橘和延、藤田良生、審良正則、北市正則、林清二、井上義一
    • Organizer
      国立病院総合医学会
    • Related Report
      2017 Research-status Report
  • [Book] 症例展開 急性増悪の治療; Respica 7月号 間質性肺炎の呼吸管理とケアコンプリートガイド2019

    • Author(s)
      新井 徹
    • Total Pages
      152
    • Publisher
      MCメディカ出版
    • ISBN
      9784840467582
    • Related Report
      2019 Research-status Report
  • [Book] 呼吸器内科実践NAVI: その他の特発性間質性肺炎2018

    • Author(s)
      新井 徹(分担執筆)
    • Total Pages
      394
    • Publisher
      南江堂
    • ISBN
      9784524259892
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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