Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
We explored new biomarkers in non-small cell lung cancers (NSCLCs). We studied PD-L1 expression by IHC in 154 surgically resected NSCLC specimens, and found H score > or = 10% in 46.8 % of specimens, which were associated with squamous cell carcinoma compared with adenocarcinoma, and with smoking. We studied SNP in PD-L1 3’UTR miRNA seeding region by NGS in 126 surgically resected NSCLC specimens, and found higher PD-L1 expression in the cancer/normal-matched group (52/114) than the cancer/normal-mismatched group (10/12) (P = 0.01).
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