The role of fatty acid composition and Sestrin in progression of pulmonary emphysema.
| Project/Area Number |
17K09643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
前野 敏孝 群馬大学, 大学院医学系研究科, 准教授 (00436297)
須永 浩章 群馬大学, 大学院医学系研究科, 研究員 (10760077)
松井 弘樹 群馬大学, 大学院保健学研究科, 准教授 (20431710)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 遊離脂肪酸 / Elovl6 / 肺気腫 / Sestrin / α1アンチトリプシン / 内科 / 脂質 / 細胞・組織 |
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| Outline of Final Research Achievements |
We examined the role of Elongation of long chain fatty acid member 6 (Elovl6) which is a rate-limiting enzyme catalysing the elongation of saturated and monounsaturated fatty acids on the development of pulmonary emphysema using Elovl6-deficient mice. In the lung tissues of Elovl6-deficient mice, the expressions of Sestrin-1, -2 and -3 were reduced in Elovl6-deficient mice, and those reductions were more significant in mice exposed to tobacco. Meanwhile, as a result of comprehensive screening of gene expression by RNA sequence, we pay attention on SerpinA1.We found that the expression of SerpinA1 in the liver of Elovl6-deficient mice was significantly reduced, and the serum concentration of Elovl6-deficient mice was also decreased in comparison with those in control mice.
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| Academic Significance and Societal Importance of the Research Achievements |
肺胞上皮細胞の脂肪酸組成を制御するElongation of long chain fatty acid member 6 (Elovl6)の発現と肺気腫との関係をElovl6欠損マウスを用いて検討した。Elovl6欠損マウスではα1-アンチトリプシンの血中濃度低下に伴って先天性の肺気腫様病変を呈し、さらに、喫煙曝露によって、α1-アンチトリプシンの活性が低下して肺気腫病変が増悪した可能性がある。したがって、肝臓での脂肪酸バランス変化が血中のα1-アンチトリプシン活性を制御することで肺疾患の発症・進展に起因することが示唆され、肺気腫の新たな治療法の開発に繋がることが期待される。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] CD36 is indispensable for nutrient homeostasis and endurance exercise capacity during prolonged fasting2018
Author(s)
Iso T, Haruyama H, Sunaga H, Matsui H, Matsui M, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Putri M, Yamaguchi A, Hanaoka H, Negishi K, Yokoyama T, Kurabayashi M
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Journal Title
Physiol Rep
Volume: 6(19)
Issue: 19
Pages: e13884-e13884
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction2017
Author(s)
Obokata M, Iso T, Ohyama Y, Sunaga H, Kawaguchi T, Matsui H, Iizuka T, Fukuda N, Takamatsu H, Koitabashi N, Funada R, Takama N, Kasama S, Kaneko Y, Yokoyama T, Murakami M, Kurabayashi M
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Journal Title
European Heart Journal: Acute Cardiovascular Care
Volume: 印刷中
Issue: 6
Pages: 561-569
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Changes in fatty acid composition by Elovl6 ameliorates pressure overload-induced cardiac remodeling through maintenance of mitochondrial integrity in cardiac myocyte.2019
Author(s)
Sayaka Tadaki, Hiroki Matsui, Hiroaki Sunaga, Yogi Umbarawan, Nozomi Furukawa, Tatsuya Iso, Norimichi Koitabashi, Takashi Matsuzaka, Hitoshi Shimano, Masahiko Kurabayashi, Tomoyuki Yokoyama.
Organizer
American Heart Association Scientific Session (AHA) 2019.
Related Report
Int'l Joint Research
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[Presentation] Activation of cardiac AMPK-FGF21 pathways during acute myocardial infarction.2019
Author(s)
Hiroaki Sunaga, Norimichi Koitabashi, Hiroki Matsui, Tatsuya Iso, Ryuichi Funada, Shu Kasama, Noriaki Takama, Takashi Nagasaka, Masami Murakami, Tomoyuki Yokoyama, Masahiko Kurabayashi.
Organizer
第83回日本循環器学会総会・学術集会
Related Report
Int'l Joint Research
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[Presentation] Deranged fatty acid composition by Elovl6 regulates cardiac inflammation and fibrosis after pressure overload in mice.2019
Author(s)
Sayaka Tadaki, Hiroki Matsui, Hiroaki Sunaga, Yogi Umbarawan, Nozomi Furukawa, Tatsuya Iso, Norimichi Koitabashi, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi.
Organizer
第83回日本循環器学会総会・学術集会
Related Report
Int'l Joint Research
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[Presentation] Genetic Deletion of Elovl6 in Cardiac Myocytes Suppresses Pressure Overload-Induced Cardiac Hypertrophy and Remodeling Through Activation of AMPK/KLF4 Signaling2018
Author(s)
Mtsui,H. Sunaga,H. Umrarawan,Y. Iso,T. Koitabashi,N. Matsuzaka,T, Shimano,H. Yokoyama,T. Kurabayashi,M.
Organizer
American Heart Association, Scientific Sessions, 2018
Related Report
Int'l Joint Research
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[Presentation] Vildagliptin Improves Ventricular Efficiency in Non-diabetic Pressure-overloaded Mouse Heart.2017
Author(s)
Nozomi Furukawa, Norimichi Koitabashi, Hiroaki Sunaga, Masaru Obokata, Yogi Umbarawan, Aiko Yamaguchi, Mas Rizky A.A Syamsunarno,Tatsuya Iso, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
Organizer
第81回日本循環器学会総会・学術集会
Related Report
