An attempt to elucidate the pathophysiology of idiopathic pulmonary fibrosis using type I alveolar epithelium-derived substance RAGE
| Project/Area Number |
17K09655
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
Iwamoto Hiroshi 広島大学, 医系科学研究科(医), 講師 (60457398)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 特発性肺線維症 / 間質性肺炎 / 急性増悪 / バイオマーカー / 治療薬 / RAGE / 特発性間質性肺炎 / 肺線維症 / 肺胞上皮 |
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| Outline of Final Research Achievements |
HMGB1 (high mobility group box-1 protein), which is secreted extracellularly when cells are damaged, is elevated in the blood of patients with intractable disease called idiopathic pulmonary fibrosis (IPF). Moreover, IPF patients with higher HMGB1 had higher risk of acute exacerbation. esRAGE (endogenous secretory receptor for advanced glycation end product), which binds to HMGB1 and suppress its effect, is decreased in patients with IPF. Moreover, IPF patients with lower esRAGE levels had poorer survival. In mouse pneumonitis model experiment, it was found that RAGE inhibitor can be applied to the treatment of pneumonitis.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究結果から、難病である特発性肺線維症患者の血中HMGB1、esRAGEを測定することにより、患者の予後や急性増悪の予測、急性増悪を起こした際の予後予測など、治療の適応を判断する上で重要な疾患進行の予測出来たことから、新規の血液検査としての可能性が示された。また動物実験の結果からはこのHMGB1、RAGEが関わる分子機構が特発性肺線維症の治療にも応用できる可能性が示され、新規治療薬の開発の一歩を示した。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis.2020
Author(s)
Yamaguchi K, Iwamoto H, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
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Journal Title
Respirology.
Volume: 25
Issue: 3
Pages: 275-280
DOI
Related Report
Peer Reviewed
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[Journal Article] Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis2020
Author(s)
Kakuhiro Yamaguchi, Hiroshi Iwamoto*, Witold Mazur, Shinichiro Miura, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
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Journal Title
Respiratory Research
Volume: -
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets.2017
Author(s)
Horimasu Y, Ishikawa N, Taniwaki M, Yamaguchi K, Hamai K, Iwamoto H, Ohshimo S, Hamada H, Hattori N, Okada M, Arihiro K, Ohtsuki Y, Kohno N
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Journal Title
BMC Med Genet
Volume: 18
Issue: 1
Pages: 88-88
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Serum high mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis2019
Author(s)
Kakuhiro Yamaguchi, Hiroshi Iwamoto, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori.
Organizer
ERS international congress 2019
Related Report
Int'l Joint Research
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