| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Although lipids are converted to a wide variety of metabolites including bioactive lipid mediators, their roles in bronchial asthma still remain incompletely understood. The aim of this study is to clarify the novel roles of lipid pathways in asthma focusing on PLA2G3, a mammalian homolog of anaphylactic bee venom PLA2. We found that PLA2G3 was predominantly expressed in airway epithelial cells, and PLA2G3 negatively regulated asthmatic responses through producing a lysophospholipid mediator. We propose that the PLA2G3-driven lipid pathway could be a new drug target of asthma.
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