Studies of therapeutic medicines for pregnancy complicated with renal disease
| Project/Area Number |
17K09682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Sato Hiroshi 東北大学, 薬学研究科, 名誉教授 (60215829)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 恵美子 東北大学, 薬学研究科, 准教授 (20466543)
高橋 信行 東北大学, 薬学研究科, 教授 (40588456)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | IgA腎症 / SLE / 腎疾患合併妊娠 / ニコチンアミド / 妊娠高血圧腎症 / 全身性エリテマトーデス / 腎障害 |
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| Outline of Final Research Achievements |
In this study, we focused on pregnancy with systemic lupus erythematosus (SLE) and IgA nephropathy as pregnancies with renal disease. These diseases are prevalent among women in their 20s and 40s who can be pregnant. In addition, pregnancy with these diseases is frequently associated with miscarriage/premature birth, fetal growth restriction, preeclampsia-like symptoms, etc., and pregnancy prognosis is poor. Therefore, it is an urgent need to develop new therapeutic medicines. We have already shown that nicotinamide, which is a vitamin B3, is a medicine that can be administrated to pregnant women and improves oxidative stress and endothelial dysfunction in preeclampsia model mice. In this study, we also found that nicotinamide showed therapeutic effects such as suppression of hypertension and improvement of fetal growth restriction in pregnancies with SLE or IgA.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により腎疾患合併妊娠であるSLE合併妊娠およびIgA腎症合併妊娠の治療にニコチンアミドが有用であることが示唆された。このことによりこれまでほとんど研究が行われていなかった腎疾患合併妊娠の基礎研究がすすみ、治療法の基盤が構築される。またニコチンアミドが腎疾患合併妊娠の治療に応用されることで、未熟児の出生率減少が期待され、また出産後の予後の改善も期待されるため、患者のQOLを向上させることが可能となる。腎疾患合併妊娠に対する治療法の研究はほとんど行われていないため、本研究は腎疾患合併妊娠における問題を解決できる可能性を示した。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition2020
Author(s)
Emiko Sato, Koji Hosomi, Akiyo Sekimoto, Eikan Mishim, Yuji Oe, Daisuke Saigusa, Sadayoshi Ito, Takaaki Abe, Hiroshi Sato, Jun Kunisawa, Toshimitsu Niwa, Nobuyuki Takahashi
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 525
Issue: 3
Pages: 773-779
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Impact of the Oral Adsorbent AST-120 on organ-specific accumulation of uremic toxins: LC-MS/MS and MS imaging techniques2018
Author(s)
Emiko Sato, Daisuke Saigusa, Eikan Mishima, Taeko Uchida, Daisuke Miura, Tomomi Morikawa-Ichinose, Kiyomi Kisu, Akiyo Sekimoto, Ritsumi Saito, Yuji Oe, Yotaro Matsumoto, Yoshihisa Tomioka, Takefumi Mori, Nobuyuki Takahashi, Hirosi Sato, Takaaki Abe, Toshimitsu Niwa, and Sadayosi Ito
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Journal Title
Toxins
Volume: 10
Issue: 1
Pages: 19-33
DOI
Related Report
Peer Reviewed / Open Access
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