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Therapeutic intervention of CKD targeting cellular oxygen sensors

Research Project

Project/Area Number 17K09688
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

Tanaka Tetsuhiro  東京大学, 医学部附属病院, 准教授 (90508079)

Co-Investigator(Kenkyū-buntansha) 川上 貴久  杏林大学, 医学部, 学内講師 (10722093)
稲城 玲子  東京大学, 医学部附属病院, 特任教授 (50232509)
南学 正臣  東京大学, 医学部附属病院, 教授 (90311620)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords低酸素 / プロリン水酸化酵素 / 慢性腎臓病 / HIF / PHD阻害薬 / 肥満関連腎症 / 糖尿病性腎臓病
Outline of Final Research Achievements

In this study, we investigated the impact of prolyl hydroxylase (PHD) inhibition in CKD progression. In BTBR/obob type 2 diabetes mice and obese mice fed with high fat diet, inhibition of PHD using PHD inhibitors significantly reduced albuminuria, which was associated with reduced glomerular infiltration of macrophages and amelioration in glomerulosclerosis. Inhibition of the cellular oxygen sensor, PHD, may be a novel therapeutic target in glomerular injury associated with type 2 diabetes and obesity.

Academic Significance and Societal Importance of the Research Achievements

慢性腎臓病(CKD)を有する人口は1000万人を超えるが、治療介入の手段は限られている。近年、低酸素生物学の進歩により、新規腎性貧血治療薬としてプロリン水酸化酵素阻害薬(PHD阻害薬)が開発され、臨床応用が開始された。本薬剤は細胞内の低酸素センサーを阻害し、低酸素応答を強化することから低酸素障害を共通背景に有する慢性腎臓病に対して保護的に作用する可能性が考えられ、本研究では同仮設を検証した。PHD阻害によって糸球体硬化とアルブミン尿の改善が認められ、CKDの進行を抑制できる可能性が示された。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (58 results)

All 2020 2019 2018 2017

All Journal Article (36 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 36 results,  Open Access: 13 results) Presentation (21 results) (of which Int'l Joint Research: 8 results,  Invited: 14 results) Book (1 results)

  • [Journal Article] Conditions, pathogenesis, and progression of diabetic kidney disease and early decliner in Japan2020

    • Author(s)
      Yoshida Y, Kashiwabara K, Hirakawa Y, Tanaka T, Noso S, Ikegami H, Ohsugi M, Ueki K, Mita T, Watada H, Koya D, Mise K, Wada J, Shimizu M, Wada T, Ito Y, Narita I, Kashihara N, Nangaku M, Matsuyama Y
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 8 Issue: 1 Pages: 1-8

    • DOI

      10.1136/bmjdrc-2019-000902

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage.2020

    • Author(s)
      Ito M, Tanaka T, Ishii T, Wakashima T, Fukui K, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 97 Issue: 4 Pages: 687-701

    • DOI

      10.1016/j.kint.2019.10.020

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice2020

    • Author(s)
      Mai Sugahara、Shinji Tanaka、Tetsuhiro Tanaka、Hisako Saito、Yu Ishimoto、Takeshi Wakashima、Masatoshi Ueda、Kenji Fukui、Akira Shimizu、Reiko Inagi、Toshimasa Yamauchi、Takashi Kadowaki、Masaomi Nangaku
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 31 Issue: 3 Pages: 560-577

    • DOI

      10.1681/asn.2019060582

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulating the immune system to delay the clinical onset of type 1 diabetes.2020

    • Author(s)
      Sugahara M, Tanaka T, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 97 Issue: 2 Pages: 248-250

    • DOI

      10.1016/j.kint.2019.10.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a prolyl hydroxylase inhibitor on kidney and cardiovascular complications in a rat model of chronic kidney disease.2020

    • Author(s)
      Uchida L, Tanaka T, Saito H, Sugahara M, Wakashima T, Fukui K, Nangaku M.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 318 Issue: 2 Pages: F388-F401

    • DOI

      10.1152/ajprenal.00419.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors.2020

    • Author(s)
      Wakashima T, Tanaka T, Fukui K, Komoda Y, Shinozaki Y, Kobayashi H, Matsuo A, Nangaku M.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 318 Issue: 1 Pages: F14-F24

    • DOI

      10.1152/ajprenal.00323.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear factor erythroid 2-related factor 2 as a treatment target of kidney diseases2020

    • Author(s)
      Ito Marie、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Current Opinion in Nephrology and Hypertension

      Volume: 29 Issue: 1 Pages: 128-135

    • DOI

      10.1097/mnh.0000000000000556

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The oral hypoxia-inducible factor prolyl hydroxylase inhibitor enarodustat counteracts alterations in renal energy metabolism in the early stages of diabetic kidney disease2019

    • Author(s)
      Hasegawa Sho、Tanaka Tetsuhiro、Saito Tomoyuki、Fukui Kenji、Wakashima Takeshi、Susaki Etsuo A.、Ueda Hiroki R.、Nangaku Masaomi
    • Journal Title

      Kidney International

      Volume: in press Issue: 5 Pages: 934-950

    • DOI

      10.1016/j.kint.2019.12.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl hydroxylase domain inhibitors: a new era in the management of renal anemia2019

    • Author(s)
      Kurata Yu、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Annals of Translational Medicine

      Volume: 7 Issue: S8 Pages: S334-S334

    • DOI

      10.21037/atm.2019.09.118

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury2019

    • Author(s)
      Hiroshi Maekawa, Tsuyoshi Inoue, haruki Ouchi, Tzu-Ming Jao, Reiko Inoue, Hiroshi Nishi, Rie Fujii, Fumiyoshi Ishidate, Tetsuhiro Tanaka, Yosuke Tanaka, Nobutaka Hirokawa, Masaomi Nangaku, Reiko Inagi
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 5 Pages: 1261-1273

    • DOI

      10.1016/j.celrep.2019.09.050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] JTZ-951 (enarodustat), a hypoxia-inducibe factor prolyl hydroxylase inhibitor, stabilizes HIF-α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor2019

    • Author(s)
      Fukui Kenji、Shinozaki Yuichi、Kobayashi Hatsue、Deai Katsuya、Yoshiuchi Hiromi、Matsui Takuya、Matsuo Akira、Matsushita Mutsuyoshi、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      European Journal of Pharmacology

      Volume: 859 Pages: 172532-172532

    • DOI

      10.1016/j.ejphar.2019.172532

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-Inducible Factor-Prolyl Hydroxylase Domain Inhibitors to Treat Anemia in Chronic Kidney Disease2019

    • Author(s)
      Sakashita Midori、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Contributions to Nephrology

      Volume: 198 Pages: 112-123

    • DOI

      10.1159/000496531

    • ISBN
      9783318064230, 9783318064247
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia/reperfusion injury.2019

    • Author(s)
      Hasegawa S, Susaki EA, Tanaka T, Komaba H, Wada T, Fukagawa M, Ueda HR, Nangaku M
    • Journal Title

      Kidney international

      Volume: AOP Issue: 1 Pages: 129-138

    • DOI

      10.1016/j.kint.2019.02.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet2019

    • Author(s)
      Saito Hisako、Tanaka Tetsuhiro、Sugahara Mai、Tanaka Shinji、Fukui Kenji、Wakashima Takeshi、Nangaku Masaomi
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 8 Pages: 1217-1232

    • DOI

      10.1038/s41374-019-0239-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in renal regeneration2019

    • Author(s)
      Hasegawa Sho、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      F1000Research

      Volume: 8 Pages: 216-216

    • DOI

      10.12688/f1000research.17127.1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regional variance in patterns of prescriptions for chronic kidney disease in Japan2019

    • Author(s)
      Inoue Reiko、Nishi Hiroshi、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 印刷中 Issue: 6 Pages: 859-864

    • DOI

      10.1007/s10157-019-01720-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulatory roles of hypoxia-inducible, noncoding RNAs on mitochondrial dynamics during AKI2019

    • Author(s)
      Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Kidney International

      Volume: 95 Issue: 2 Pages: 252-253

    • DOI

      10.1016/j.kint.2018.12.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis2019

    • Author(s)
      Jao Tzu-Ming、Nangaku Masaomi、Wu Chia-Hsien、Sugahara Mai、Saito Hisako、Maekawa Hiroshi、Ishimoto Yu、Aoe Mari、Inoue Tsuyoshi、Tanaka Tetsuhiro、Staels Bart、Mori Kazutoshi、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 95 Issue: 3 Pages: 577-589

    • DOI

      10.1016/j.kint.2018.09.023

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Anticipated Renoprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors2018

    • Author(s)
      Ito M, Tanaka T.
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 15 Pages: 2105-2114

    • DOI

      10.2169/internalmedicine.9842-17

    • NAID

      130007429844

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-08-01
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 20182018

    • Author(s)
      Japanese Society of Nephrology
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 23 Issue: 1 Pages: 1-15

    • DOI

      10.1007/s10157-018-1648-1

    • NAID

      120007128066

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Safety and effectiveness of long-term use of darbepoetin alfa in non-dialysis patients with chronic kidney disease: a post-marketing surveillance study in Japan2018

    • Author(s)
      Tanaka Tetsuhiro、Nangaku Masaomi、Imai Enyu、Tsubakihara Yoshiharu、Kamai Masatoshi、Wada Michihito、Asada Shinji、Akizawa Tadao
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 23 Issue: 2 Pages: 231-243

    • DOI

      10.1007/s10157-018-1632-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease2018

    • Author(s)
      Hasegawa Sho、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Current Opinion in Nephrology and Hypertension

      Volume: 27 Issue: 5 Pages: 331-338

    • DOI

      10.1097/mnh.0000000000000431

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Physiological and pathophysiological role of reactive oxygen species and reactive nitrogen species in the kidney2018

    • Author(s)
      Ishimoto Yu、Tanaka Tetsuhiro、Yoshida Yoko、Inagi Reiko
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology

      Volume: 45 Issue: 11 Pages: 1097-1105

    • DOI

      10.1111/1440-1681.13018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sodium glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice2018

    • Author(s)
      Tanaka Shinji、Sugiura Yuki、Saito Hisako、Sugahara Mai、Higashijima Yoshiki、Yamaguchi Junna、Inagi Reiko、Suematsu Makoto、Nangaku Masaomi、Tanaka Tetsuhiro
    • Journal Title

      Kidney International

      Volume: 94 Issue: 5 Pages: 912-925

    • DOI

      10.1016/j.kint.2018.04.025

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Guidelines for clinical evaluation of chronic kidney disease2018

    • Author(s)
      Kanda Eiichiro、Research Working Group for Establishing Guidelines for Clinical Evaluation of Chronic Kidney Disease、Kashihara Naoki、Matsushita Kunihiro、Usui Tomoko、Okada Hirokazu、Iseki Kunitoshi、Mikami Kenichi、Tanaka Tetsuhiro、Wada Takashi、Watada Hirotaka、Ueki Kohjiro、Nangaku Masaomi
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Issue: 6 Pages: 1446-1475

    • DOI

      10.1007/s10157-018-1615-x

    • NAID

      120006557512

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response2018

    • Author(s)
      Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 94 Issue: 3 Pages: 536-550

    • DOI

      10.1016/j.kint.2018.03.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persistent expression of neutrophil gelatinase-associated lipocalin and M2 macrophage markers and chronic fibrosis after acute kidney injury2018

    • Author(s)
      Saito Hisako、Tanaka Tetsuhiro、Tanaka Shinji、Higashijima Yoshiki、Yamaguchi Junna、Sugahara Mai、Ito Marie、Uchida Lisa、Hasegawa Sho、Wakashima Takeshi、Fukui Kenji、Nangaku Masaomi
    • Journal Title

      Physiological Reports

      Volume: 6 Issue: 10 Pages: e13707-e13707

    • DOI

      10.14814/phy2.13707

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] HIF Activation Against CVD in CKD: Novel Treatment Opportunities2018

    • Author(s)
      Tanaka Tetsuhiro、Eckardt Kai-Uwe
    • Journal Title

      Seminars in Nephrology

      Volume: 38 Issue: 3 Pages: 267-276

    • DOI

      10.1016/j.semnephrol.2018.02.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia.2018

    • Author(s)
      Hirakawa Y, Mizukami K, Yoshihara T, Takahashi I, Khulan P, Honda T, Mimura I, Tanaka T, Tobita S, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 印刷中 Issue: 6 Pages: 1483-1489

    • DOI

      10.1016/j.kint.2018.01.015

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.2018

    • Author(s)
      Mimura I, Hirakawa Y, Kanki Y, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
    • Journal Title

      Sci Rep.

      Volume: 28 Issue: 1 Pages: 3779-3779

    • DOI

      10.1038/s41598-018-22180-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] PHD in the FOXD1 lineage cells links hypoxia to inappropriate nephrogenesis.2017

    • Author(s)
      Tanaka T.
    • Journal Title

      Kidney Int.

      Volume: 92 Issue: 6 Pages: 1314-1316

    • DOI

      10.1016/j.kint.2017.08.022

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner.2017

    • Author(s)
      Yamaguchi J, Tanaka T, Saito H, Nomura S, Aburatani H, Waki H, Kadowaki T, Nangaku M.
    • Journal Title

      Sci Rep.

      Volume: 26 Issue: 1 Pages: 6516-6516

    • DOI

      10.1038/s41598-017-06761-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease.2017

    • Author(s)
      Sugahara M, Tanaka T, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 92 Issue: 2 Pages: 306-312

    • DOI

      10.1016/j.kint.2017.02.035

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Changes in the Acute Kidney Injury-to-Chronic Kidney Disease Transition.2017

    • Author(s)
      Nangaku M, Hirakawa Y, Mimura I, Inagi R, Tanaka T.
    • Journal Title

      Nephron.

      Volume: 137 Issue: 4 Pages: 256-259

    • DOI

      10.1159/000476078

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy.2017

    • Author(s)
      Levin A, Tonelli M, Bonventre J, Coresh J, Donner JA, Fogo AB, Fox CS, Gansevoort RT, Heerspink HJL, Jardine M, Kasiske B, Köttgen A, Kretzler M, Levey AS, Luyckx VA, Mehta R, Moe O, Obrador G, Pannu N, Parikh CR, Perkovic V, Pollock C, Stenvinkel P, Tuttle KR, Wheeler DC, Eckardt KU et al.
    • Journal Title

      Lancet.

      Volume: 390 Issue: 10105 Pages: 1888-1917

    • DOI

      10.1016/s0140-6736(17)30788-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.2017

    • Author(s)
      Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
    • Journal Title

      Physiol Rep.

      Volume: 5 Issue: 8 Pages: e13203-e13203

    • DOI

      10.14814/phy2.13203

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] PHD阻害薬の臨床試験2019

    • Author(s)
      田中哲洋
    • Organizer
      第62回日本腎臓学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 臓器透明化と酸素モニタリングを糸口とする虚血性腎障害の病態解明2019

    • Author(s)
      田中哲洋
    • Organizer
      第62回日本腎臓学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CKDと酸素代謝異常2019

    • Author(s)
      田中哲洋、南学正臣
    • Organizer
      第92回日本生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] HIF-PHD阻害薬2019

    • Author(s)
      田中哲洋
    • Organizer
      第64回日本透析医学会学術集会・総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] エリスロポエチン産生誘導と腎性貧血治療の新展開2019

    • Author(s)
      田中哲洋
    • Organizer
      脳心血管抗加齢研究会2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] HIF STABILIZERS FOR THE TREATMENT OF RENAL ANEMIA2019

    • Author(s)
      Tetsuhiro Tanaka
    • Organizer
      World Congress of Nephrology 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Treating Dyslipidemias & Hyperuricemia in kidney disease2019

    • Author(s)
      Tetsuhiro Tanaka
    • Organizer
      PAKISTAN SOCIETY OF NEPHROLOGY CONFERENCE 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Multiple consequences of HIF activation in CKD2019

    • Author(s)
      Tetsuhiro Tanaka
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Inhibition of prolyl hydroxylase domain might suppress macrophage infiltration and cardiac fibrosis in the chronic kidney disease rat model with cardiomyopathy2018

    • Author(s)
      Lisa Uchida, Tetsuhiro Tanaka, Hisako Saito, Kenji Fukui, Takeshi Wakashima, Masaomi Nanagaku
    • Organizer
      ERA-EDTA meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] DETERMINATION OF OXYGEN TENSION IN TUBULAR EPITHELIAL CELLS USING PHOSPHORESCENCE LIFETIME IMAGING MICROSCOPY.2018

    • Author(s)
      Yosuke Hirakawa, Kiichi Mizukami, Toshitada Yoshihara, Tomoko Honda, Imari Mimura, Tetsuhiro Tanaka, Seiji Tobita, Masaomi Nangaku.
    • Organizer
      ERA-EDTA meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] PHD inhibition reduces reactive oxidative stress in in vitro ischemia model2018

    • Author(s)
      Marie Ito, Tetsuhiro Tanaka, Masaomi Nangaku
    • Organizer
      ASN Kidney Week 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiple, Systemic Effects of PHD Inhibitors Signify an Anti-Fibrotic and Anti-Inflammatory Impact on Cardiovascular Complications in the Remnant Kidney2018

    • Author(s)
      Lisa Uchida, Tetsuhiro Tanaka, Hisako Saito, Mai Sugahara, Kenji Fukui, Takeshi Wakashima, Masaomi Nangaku
    • Organizer
      ASN Kidney Week 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Epigenetic changes induced by HIF- hypoxic memory -2018

    • Author(s)
      Tetsuhiro Tanaka
    • Organizer
      NephrologyMeet2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A role of hypoxia-signaling in diabetic kidney disease2018

    • Author(s)
      Tetsuhiro Tanaka
    • Organizer
      NephrologyMeet2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Determination of oxygen tension in normal and fibrotic kidney using phosphorescence lifetime imaging microscope.2018

    • Author(s)
      Yosuke Hirakawa, Kiichi Mizukami, Tomoko Honda, Toshitada Yoshihara, Imari Mimura, Tetsuhiro Tanaka, Seiji Tobita, Masaomi Nangaku
    • Organizer
      2018年度日本腎臓学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] The effect of HIF stabilizers on anemia, CKD and metabolic disorders2018

    • Author(s)
      Tetsuhiro Tanaka
    • Organizer
      2018年度日本腎臓学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Clinical Trials of PHD inhibitors2018

    • Author(s)
      Tetsuhiro Tanaka
    • Organizer
      第63回日本透析医学会学術集会・総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Gene Expression Profiles of Glomeruli from BTBR ob/obMice Treated with Prolyl Hydroxylase Inhibitor Suggest Involvement of Extracellular Matrix Modulators in Pathogenesis of Diabetic Kidney Disease2017

    • Author(s)
      Mai Sugahara, Shinji Tanaka, Tetsuhiro Tanaka, Kenji Fukui, Akira Shimizu, Yu Ishimoto, Reiko Inagi, Masaomi Nangaku
    • Organizer
      ASN Kidney Week 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inhibition of prolyl hydroxylase domain (PHD) reduces glomerular macrophage infiltration and improves albuminuria in mice with high fat diet2017

    • Author(s)
      Hisako Saito, Tetsuhiro Tanaka, Mai Sugahara, Kenji Fukui, Takeshi Wakashima, Masaomi Nangaku
    • Organizer
      ASN Kidney Week 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 酸素代謝異常からみた糖尿病性腎臓病2017

    • Author(s)
      田中哲洋
    • Organizer
      第54回日本臨床分子医学会学術総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 低酸素のイメージング2017

    • Author(s)
      田中哲洋
    • Organizer
      2017年度日本腎臓学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] Comprehensive Clinical Nephrology2018

    • Author(s)
      Richard J. Johnson, John Feehally, Jurgen Floege, Marcello Tonelli, et al.
    • Total Pages
      1360
    • Publisher
      Elsevier
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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