| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Fibrosis is characterized by an excessive wound healing response to organ damage, causing extracellular matrix deposition and accumulation of fibroblasts/myofibroblasts. Recently, chronic kidney disease (CKD) has been thought as being at risk of developing end-stage renal disease. In the process of CKD progression to renal failure, various renal diseases are characterized by taking a common process which is renal interstitial fibrosis. In this study, we attempted to elucidate the significance of cytoskeleton-dependent signals for renal interstitial fibrosis by regulating the biological properties of renal resident cells. As a result, it was revealed that the cytoskeleton-dependent signal by TGF-b1 in renal resident cells contributes to the progression of renal interstitial fibrosis by inducing myofibroblast differentiation.
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