Involvement of cytoskeleton-dependent signaling in renal fibrosis
| Project/Area Number |
17K09691
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 腎不全 / 線維化 / 慢性腎臓病 / 腎臓 |
|---|
| Outline of Final Research Achievements |
Fibrosis is characterized by an excessive wound healing response to organ damage, causing extracellular matrix deposition and accumulation of fibroblasts/myofibroblasts. Recently, chronic kidney disease (CKD) has been thought as being at risk of developing end-stage renal disease. In the process of CKD progression to renal failure, various renal diseases are characterized by taking a common process which is renal interstitial fibrosis. In this study, we attempted to elucidate the significance of cytoskeleton-dependent signals for renal interstitial fibrosis by regulating the biological properties of renal resident cells. As a result, it was revealed that the cytoskeleton-dependent signal by TGF-b1 in renal resident cells contributes to the progression of renal interstitial fibrosis by inducing myofibroblast differentiation.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究では、細胞骨格に関連するシグナルが、腎臓を構成する細胞の機能を調節することで腎不全の原因となる線維化に関与するかを試みた。その結果、腎構成細胞において、細胞骨格シグナルが、線維化に関与する細胞を活性化させ、腎線維化進展に寄与することを明らかにした。これは腎障害の原因に関わらない共通機序であり、現在増加の一途を辿っている末期腎不全患者数の抑制につながる新規治療法開発につながることが期待される。
|
Report
(4 results)
Research Products
(20 results)
-
-
-
-
-
-
[Journal Article] Erythropoietin signal protected HUVEC from high glucose induced injury2019
Author(s)
Yasuda Haruka、Iwata Yasunori、Nakajima Satoshi、Furuichi Kengo、Miyake Taito、Sakai Norihiko、Kitajima Shinji、Toyama Tadashi、Shinozaki Yasuyuki、Sagara Akihiro、Miyagawa Taro、Hara Akinori、Shimizu Miho、Kamikawa Yasutaka、Sato Kouichi、Oshima Megumi、Yoneda-Nakagawa Shiori、Kaneko Shuichi、Wada Takashi
-
Journal Title
Nephrology (Carlton)
Volume: in press
Pages: 767-774
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Clinical and pathological significance of autoantibodies to erythropoietin receptor in type 2 diabetic patients with chronic kidney disease2018
Author(s)
Hara A, Furuichi K, Koshino A, Yasuda H, Tran T, Iwata Y, Sakai N, Shimizu M, Kaneko S, Nakamura H, Wada T.
-
Journal Title
Kidney International Reports
Volume: 3
Pages: 133-141
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
[Presentation] Regulation of renal fibroblast function by MRTF-focal adhesion in response to TGF-b12019
Author(s)
Norihiko Sakai, Koichi Sato, Hisayuki Ogura, Taro Miyagawa, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Miho Shimizu, Kengo Furuichi, Takashi Wada
Organizer
アメリカ腎臓学会
Related Report
Int'l Joint Research
-
-
[Presentation] Regulation of renal fibroblast migration, proliferation and myofibroblast differentiation by LPA-LPA1 signaling via specific G proteins2018
Author(s)
Norihiko Sakai, Koichi Sato, Taito Miyake, Akihiro Sagara, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Miho Shimizu, Kengo Furuichi, Takashi Wada.
Organizer
米国腎臓学会
Related Report
Int'l Joint Research
-
-
-
-
