Fundamental research for developing CKD therapy focusing on novel long non-coding RNA

• Project/Area Number: 17K09703
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: Morinaga Jun 熊本大学, 病院, 病院教員 (50459210)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 長鎖ノンコーディングRNA / 慢性腎臓病 / 腎臓学

Outline of Final Research Achievements

In order to clarify the role of lnc-RNA-X in the progression of CKD, Jun Morinaga performed animal studies and demonstrated that lnc-RNA-X have favorable effects on some CKD progression. However, further studies are needed to clarify the role of lnc-RNA-X in the progression of CKD.

Academic Significance and Societal Importance of the Research Achievements

本研究は慢性腎臓病進展においてある長鎖ノンコーディングRNAに着目した研究であるが、本研究の成果は、将来における新たな腎不全治療薬の開発のための重要な手がかりとなる可能性がある。