Elucidation of the role of homeostatic inflammation in the AKI to CKD transition mechanism focusing on the time phase changes
| Project/Area Number |
17K09704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
桑原 孝成 熊本大学, 大学院生命科学研究部(医), 講師 (00393356)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | AKI / CKD / マクロファージ / 急性腎障害 / 慢性腎臓病 / 内科 |
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| Outline of Final Research Achievements |
We examined the role of MRP8 in each phase of the transition process from CKD to CKD. Eight to nine week-old male MRP8 knockout mice and control mice were subjected to left renal ischemia-reperfusion injury for 30 minutes without right nephrectomy. Macrophages were sorted using FACS analysis 2, 7 and 16 days after kidney injury, and then inflammation- and fibrosis-related molecules were analyzed by real-time PCR. As a result, no difference between groups was observed between the MRP8 knockout mouse and the control mouse.
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| Academic Significance and Societal Importance of the Research Achievements |
急性腎障害患者が慢性腎臓病へ移行する過程で、TLR4に関連する炎症が関与していることは示唆されるものの、TLR4リガンドであるMRP8と腎障害慢性化との間に明確な関連を見出す結果には至らなかった。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study2019
Author(s)
Morinaga J, Kakuma T, Fukami H, Hayata M, Uchimura K, Mizumoto T, Kakizoe Y, Miyoshi T, Shiraishi N, Adachi M, Izumi Y, Kuwabara T, Okadome Y, Sato M, Horiguchi H, Sugizaki T, Kadomatsu T, Miyata K, Tajiri S, Tajiri T, Tomita K, Kitamura K, Oike Y, Mukoyama M.
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Journal Title
Nephrology Dialysis Transplantation
Volume: 印刷中
Issue: 5
Pages: 854-860
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Refractory peritonitis by spontaneous perforation of the common bile duct in a patient receiving peritoneal dialysis2017
Author(s)
Manabu Hayata, Junji Yamashita, Kentaro Tokunaga, Masashi Ejima, Katsuyuki Sagishima, Shigeki Nakagawa, Daisuke Hashimoto, Hideo Baba, Kosuke Maruyama, Yu Kohrogi, Teruhiko Mizumoto, Masashi Mukoyama and Hidenobu Kamohara
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Journal Title
Renal Replacement Therapy
Volume: 3: 53
Pages: 1-1
Related Report
Peer Reviewed / Open Access
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[Presentation] CKDにおけるMRP8の化学修飾の探索とその意義の検討2018
Author(s)
神吉 智子, 桑原 孝成, 梅本 周朗, 藤本 大介, 水本 輝彦, 早田 学, 中山 憲司, 宮崎 有, 井上 貴博, 小川 修, 向山 政志
Organizer
日本腎臓学会
Related Report
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