| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The initial profiling of senescence-associated mice screened miRNAs whose expression was different from control mice. Among them, serum levels of miRNA-142-3p were decreased and those of miRNA-503-3p were increased in patinets with age-dependent renal impairment compared with age-matched population who have reguar renal function. Furthermore, miRNA-503-3p-inhibitor significantly inhibited renal fibrosis which was observed in senescence-associated mice in vivo. However, miRNA-142-3p-mimic did not show these treatment effects.These results suggest that miRNA-142-3p and miRNA-503-3p are useful as novel diagnostic biomarkers, and miRNA-503-3p may be a therapeutic target for age-dependent renal impariment.
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