| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Circulating TNF receptor (TNFR) levels predict all-cause mortality in hemodialysis patients, but not their ligands [TNFα, Progranulin (PGRN)]. Prednisolone treatment decreased circulating TNFR2 levels in addition to improvement of proteinuria and hematuria in patients with IgA nephropathy.
Renal mRNA levels of TNFα and TNFR2 were increased, but their circulating levels decreased in high-fat diet-fed PGRN knockout mice compared with their wild type mice. PRGN may show both inflammatory and anti-inflammatory effects depending on organ such as kidney and adipose tissue.
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