| Project/Area Number |
17K09714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Tsuchiya Ken 東京女子医科大学, 医学部, 教授 (00246472)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Klotho / 慢性腎臓病 / リン / 急性腎障害 / 虚血 / FGF23 / 繊維化 / CKD / AKI |
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| Outline of Final Research Achievements |
The essential pathological condition of chronic kidney disease (CKD) is assumed to be due to a chronic failure of maintaining homeostasis of the body such as water / electrolyte, metabolic abnormality, anemia due to renal tubular function / interstitial region disorder. It is proposed that the onset, progression, and aggravation of CKD are caused by the accumulation of various degrees of frequent renal injury (including AKI: acute kidney injury). Researchers have traditionally focused on the Klotho protein, which is a phosphorus regulator and has physiological activities such as anti-aging and anti-fibrosis, and has hypothesized that it is greatly involved in the pathophysiology of CKD. As an experimental model, we established a model in which CKD develops and progress in mice with low expression of the klotho with frequent and minimally invasive disorders, and examined the significance of various disease exacerbating factors.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性腎臓病(CKD)の本質的な病態は、腎尿細管機能・間質部の障害による水・電解質、代謝異常、貧血などの生体の恒常性維持の慢性的な破綻が、全身的な臓器障害、特に循環・血管系の動脈硬化病変、石灰化などを引き起こし、心腎連関などと総称される、全体的な病態像を形成すると考えられている。最近、CKDの発症・進展・重症化には、種々の程度の頻回な腎障害(AKI: acute kidney injuryを含む)が集積することにより生じうることが注目されている。それは、特定の原因疾患によらず、CKDが発症もしくは増悪する可能性を示唆し、特に高齢化社会では末期腎不全・透析の患者が増加する結果となる。
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