Relationship between prebiotics and insulin signaling in kidney: Novel approaches to the treatment of CKD using intestine-renal connection
| Project/Area Number |
17K09720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka Medical College (2019-2020)
Kindai University (2017-2018) |
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Principal Investigator |
MIMA AKIRA 大阪医科大学, 医学部, 特別職務担当教員(教授) (00432401)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 慢性腎臓病 / 腸内フローラ / プレバイオティクス / インスリンシグナル / インスリン受容体基質 |
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| Outline of Final Research Achievements |
The aging society and changes in lifestyle have rapidly accelerated the number of chronic kidney disease (CKD) patients, and the medical cost of CKD exceeds 4 trillion yen per year, making it a social problem. In this study, we investigated the effects of prebiotics on glomerular insulin signaling, mainly insulin receptor substrate (IRS)1, and renal protection by improving intestinal flora, which has not been clarified so far. Lactulose was administered as a prebiotic to CKD rats, and intestinal flora, renal function, and renal tissue were examined. The intestinal flora of the lactulose group increased beneficial bacteria, and at the same time, albuminuria was decreased and glomerular filtration rate was improved compared to CKD rats.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究が目指すものは「腸腎連関」という新たな概念に基づくCKD治療法の確立であり、従来の治療法と全く異なる。プレバイオティクスはヒトに直接消化、吸収されない成分であり安全性が高く、さらに安価である。つまり、本研究の成果により低リスク、かつ低コストCKD新規治療法が確立することが考えられ、そのインパクトは極めて大きい。
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Successful treatment of highly advanced immunoglobulin G4-related kidney disease presenting renal mass-like regions with end-stage kidney failure: a case study2017
Author(s)
Ono H, Murakami T, Mima A, Shibata E, Tamaki M, Yoshimoto S, Ueda S, Kishi F, Kishi S, Kawanaka T, Matsuura M, Nagai K, Abe H, Harada M, Doi T
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Journal Title
BMC Nephrol
Volume: 18
Issue: 1
Pages: 261-261
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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