| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The number of patients with chronic kidney disease (CKD) and dialysis patients is increasing. Until now, the mortality risk of maintenance dialysis patients has been dictated by the concentration of plasma phosphate (Pi) during fasting in the early morning, but the mechanism remains unclear. The present study elucidated the diurnal rhythm of plasma Pi concentration and revealed that the rhythm was regulated by the liver Nampt/NAD system. Furthermore, activation of the liver Nampt/NAD system was suggested to regulate Pi influxin the tissues.
The control of the Nampt/NAD system by the liver phosphaturic factor is considered to be useful for a new CKD treatment study with hyperphosphatemia that considers the diurnal rhythm of plasma Pi concentration.
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