Control of multi-organ communication and treatment of CKD by hepatic phosphaturic factor
| Project/Area Number |
17K09727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Shiga Prefecture |
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Principal Investigator |
Sawako Tatsumi 滋賀県立大学, 人間文化学部, 教授 (80420545)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 慢性腎臓病 / リン / Nampt / 肝臓 / 腎臓 / CKD |
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| Outline of Final Research Achievements |
The number of patients with chronic kidney disease (CKD) and dialysis patients is increasing. Until now, the mortality risk of maintenance dialysis patients has been dictated by the concentration of plasma phosphate (Pi) during fasting in the early morning, but the mechanism remains unclear. The present study elucidated the diurnal rhythm of plasma Pi concentration and revealed that the rhythm was regulated by the liver Nampt/NAD system. Furthermore, activation of the liver Nampt/NAD system was suggested to regulate Pi influxin the tissues.
The control of the Nampt/NAD system by the liver phosphaturic factor is considered to be useful for a new CKD treatment study with hyperphosphatemia that considers the diurnal rhythm of plasma Pi concentration.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性腎臓病（CKD）リスクとなる生活習慣病の患者の増加を背景として、CKD患者数は増加傾向にあり、新規透析導入数は年々上昇している。さらに透析は患者のQOLを低下させるため、新たな先制治療戦略が必要であることは周知されている。
研究期間内に実施した研究及びその成果は、『肝リン利尿因子が繋ぐ多臓器連関制御』の機序解明により慢性腎臓病治療の新たな新戦略に貢献するものであり、学術的、社会的意義があると考えられる。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages.2020
Author(s)
Hanazaki A, Ikuta K, Sasaki S, Sasaki S, Koike M, Tanifuji K, Arima Y, Kaneko I, Shiozaki Y, Tatsumi S, Hasegawa T, Amizuka N, Miyamoto KI, Segawa H.
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Journal Title
Physiol Rep.
Volume: Feb;8(3)
Issue: 3
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.2019
Author(s)
Fujii T, Segawa H, Hanazaki A, Nishiguchi S, Minoshima S, Ohi A, Tominaga R, Sasaki S, Tanifuji K, Koike M, Arima Y, Shiozaki Y, Kaneko I, Ito M, Tatsumi S, Miyamoto KI
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Journal Title
Clin Exp Nephrol.
Volume: in press
Issue: 7
Pages: 898-907
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.2019
Author(s)
Fujii T, Shiozaki Y, Segawa H, Nishiguchi S, Hanazaki A, Noguchi M, Kirino R, Sasaki S, Tanifuji K, Koike M, Yokoyama M, Arima Y, Kaneko I, Tatsumi S, Ito M, Miyamoto KI.
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Journal Title
Clin Exp Nephrol
Volume: 23(3)
Issue: 3
Pages: 313-324
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse.2018
Author(s)
Kaneko I, Segawa H, Ikuta K, Hanazaki A, Fujii T, Tatsumi S, Kido S, Hasegawa T, Amizuka N, Saito H, Miyamoto KI.
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Journal Title
Endocrinology
Volume: 159(7)
Issue: 7
Pages: 2741-2758
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling2018
Author(s)
Ikuta K, Segawa H, Sasaki S, Hanazaki A, Fujii T, Kushi A, Kawabata Y, Kirino R, Sasaki S, Noguchi M, Kaneko I, Tatsumi S, Ueda O, Wada NA, Tateishi H, Kakefuda M, Kawase Y, Ohtomo S, Ichida Y, Maeda A, Jishage KI, Horiba N, Miyamoto KI.
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Journal Title
Clin Exp Nephrol.
Volume: 印刷中
Issue: 3
Pages: 1497-1503
DOI
Related Report
Peer Reviewed
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[Journal Article] The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of the plasma inorganic phosphate concentration.2018
Author(s)
Miyagawa A, Tatsumi S, Takahama W, Fujii O, Nagamoto K, Kinoshita E, Nomura K, Ikuta K, Fujii T, Hanazaki A, Kaneko I, Segawa H, Miyamoto KI.
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Journal Title
Kidney Int.
Volume: 印刷中
Issue: 5
Pages: 1073-1085
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of Osteocyte-Ablation on Inorganic Phosphate Metabolism: Analysis of Bone-Kidney-Gut Axis2017
Author(s)
Fujii O, Tatsumi S, Ogata M, Arakaki T, Sakaguchi H, Nomura K, Miyagawa A, Ikuta K, Hanazaki A, Kaneko I, Segawa H, Miyamoto KI.
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Journal Title
Front Endocrinol (Lausanne)
Volume: 8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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