| Project/Area Number |
17K09740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 章雄 東京慈恵会医科大学, 医学部, 助教 (20624688)
浦島 充佳 東京慈恵会医科大学, 医学部, 教授 (80203602)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 慢性腎臓病 / ミネラル代謝異常 / 糖・エネルギー代謝 / resistin / リン代謝 / ビタミンD / 糖代謝 / 鉄代謝 / 筋肉量 / Vitamin D / ミネラル代謝 / 糖代謝異常 |
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| Outline of Final Research Achievements |
To clarify the relationship between vitamin D-related abnormalities in mineral metabolism and glucose-energy metabolism, the following four studies were planned.Study 1: Exploratory study of the relationship between vitamin D and muscle and energy metabolism using BioRad (a kit for measuring molecules related to glucose-energy metabolism)Study 2. an exploratory study of the relationship between vitamin D and grip strength in dialysis patients.Study 3. cross-sectional study of vitamin D and lifestyle-related diseases in physical examination patients.Study 4: Intervention studies to clarify the effects of adding vitamin D to the diet of animal models of muscle atrophy on muscle metabolism, glucose and energy metabolism.
Based on the results of the above studies, we will further clarify the relationship between vitamin D-related abnormalities in mineral metabolism and glucose-energy metabolism.
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| Academic Significance and Societal Importance of the Research Achievements |
ミネラル代謝異常は慢性腎臓病患者の生命予後および合併症に関連する最も強力な関連因子の一つである。我々は、腎と各種臓器連関の主要な因子としてビタミンD代謝障害に加えて、インスリン抵抗性に焦点を中てて研究を進めてきた。
基礎研究から、慢性腎臓病患者、健診患者と広く対象を広げ、本研究の結果を基に、慢性腎臓病患者のミネラル管理-糖代謝管理-運動を包括的にアプローチする臨床ガイドを作成したい。
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