| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We carried out TDP-43 mRNA alternative splicing (AS) analysis to elucidate the pathomechanism of amyotrophic lateral sclerosis (ALS). TDP-43 is a major component of inclusion body in ALS and is a key molecule of this disease. We found a unique TDP-43 mRNA AS pattern in neural tissue from ALS autopsied cases. Furthermore, the protein derived from the AS mRNA showed easy aggregation property. The same AS pattern was also found in the cerebellum, which is a non-injured tissue of ALS, but no difference was found in the blood cell mRNA from the control group, and it was not established as a biomarker.
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