| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In the present study, it was revealed that LPS is effluxed into the blood due to disruption of intestinal barrier function due to dysbiosis in the pathophysiology of diabetes mellitus due to chronic cerebral ischemia, resulting in metabolic endotoxemia. In addition, lipopolysaccharide (LPS) in blood acts on toll like receptor 4 (TLR4) whose expression is increased in the brain due to disruption of blood-brain barrier function due to cerebral ischemia. Moreover, activated immunocompetent cells produce inflammatory cytokines, and progresses inflammatory response. We have proved that the development of inflammatory reaction derived from dysbiosis causes onset and development of brain white matter damage.
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