| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
Parkin, the gene product responsible for juvenile Parkinson's disease, is involved in mitophagy to eliminate defective mitochondria. In this study, we identified PUBP1 as a molecule that binds to the phosphorylated polyubiquitin chains formed by Parkin and analyzed its function. When Parkin-dependent mitophagy was induced, PUBP1 was partially translocated from the cytoplasm to the mitochondria. In contrast, mitophagy was inhibited in PUBP1-deficient cells. These observations suggest that PUBP1 is a facilitator of Parkin-dependent mitophagy, and that the activity of PUBP1 may affect the pathogenesis of juvenile Parkinson's disease.
|
