Systematic brain search of Parkinson's Disease with functional neuroimaging

• Project/Area Number: 17K09793
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: HIRANO SHIGEKI 千葉大学, 医学部附属病院, 講師 (60375756)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: パーキンソン病 / 脳血流 / ドパミン / 認知機能 / 線条体 / 前頭葉 / 脳深部刺激療法 / 描画機能 / 言語機能 / 尾状核 / 知能 / 非運動症状 / ドパミントランスポーター / ネットワーク解析 / 画像症候連関

Outline of Final Research Achievements

We have reported that drawing disability may develop after bilateral subthalamic nucleus deep brain stimulation surgery about half of patients with Parkinson's disease (PD). By using perfusion neuroimage, anterior cingulate cortex was specifically reduced in those who exhibited drawing difficulties which may indicate the involvement of the limbic circuits of PD after surgery.
Dopamine transporter imaging was performed in 30 healthy volunteers and showed that verbal intelligence quotient correlate with caudate dopaminergic function. This result may partly explains why elder people, as well as PD patients experience difficulty in verbal fluency.
These neuroimaging findings further explain the pathophysiological basis of cognitive symptoms pf patients with PD.

Academic Significance and Societal Importance of the Research Achievements

進行期パーキンソン病の運動障害に対して行われる両側視床下核深部脳刺激療法において、術後約半数の方に描画障害が認められることが分かった。描画機能の障害の長期的予後を今後調査していく必要がある。健常者での尾状核ドパミン神経活動は、年齢の影響を除いても、言語機能と関連していることが分かった。尾状核ドパミン神経は正常な加齢においても次第に低下していくため、加齢やパーキンソン病にて認められる言語表出困難は尾状核ドパミン神経機能の低下が原因の一つである可能性がある。機能画像を用いて、認知機能障害の一面を解明することができた。

Research Products

• [Int'l Joint Research] Feinstein Institute of Medical Research(米国)
• [Journal Article] Decline in drawing ability and cerebral perfusion in Parkinson's disease patients after subthalamic nucleus deep brain stimulation surgery (2020)
  • Author(s): Furukawa Shogo、Hirano Shigeki、Yamamoto Tatsuya、Asahina Masato、Uchiyama Tomoyuki、Yamanaka Yoshitaka、Nakano Yoshikazu、Ishikawa Ai、Kojima Kazuho、Abe Midori、Uji Yuriko、Higuchi Yoshinori、Horikoshi Takuro、Uno Takashi、Kuwabara Satoshi
  • Journal Title: Parkinsonism & Related Disorders Volume: 70 Pages: 60-66
  • DOI: 10.1016/j.parkreldis.2019.12.002
  • Peer Reviewed
• [Journal Article] The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging (2020)
  • Author(s): Li Hongliang、Hirano Shigeki、Furukawa Shogo、Nakano Yoshikazu、Kojima Kazuho、Ishikawa Ai、Tai Hong、Horikoshi Takuro、Iimori Takashi、Uno Takashi、Matsuda Hiroshi、Kuwabara Satoshi
  • Journal Title: Frontiers in Aging Neuroscience Volume: 12 Pages: 41-41
  • DOI: 10.3389/fnagi.2020.00041
  • Peer Reviewed / Open Access
• [Journal Article] Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT (2018)
  • Author(s): Matsuda H, Murata M, Mukai Y, Sako K, Ono H, Toyama H, Inui Y, Taki Y, Shimomura H, Nagayama H, Tateno A, Ono K, Murakami H, Kono A, Hirano S, Kuwabara S, Maikusa N, Ogawa M, Imabayashi E, Sato N, Takano H, Hatazawa J, Takahashi R
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 45 Issue: 8 Pages: 1405-1416
  • DOI: 10.1007/s00259-018-3976-5
  • Peer Reviewed / Open Access
• [Presentation] 脳血流画像を馬鹿にするものは臨床診断に泣く！ (2019)
  • Author(s): 平野成樹
  • Organizer: 第60回日本神経学会学術大会
  • Invited
• [Presentation] The relationship between striatal dopamine transporter and cognitive function in healthy subjects (2018)
  • Author(s): Hongliang Li, Shigeki Hirano, Shougo Furakawa, Kazuho Kojima, Keisuke Shimizu , Yoshikazu Nakano, Hong Tai , Hiroki Mukai, Takashi Uno, Takashi Iimori, Hiroshi Matsuda, Satoshi Kuwabara
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] Striato-Prefrontal Projection in parkinsonian syndrome with perfusion and dopamine transporter SPECT (2018)
  • Author(s): Yoshikazu Nakano, Shigeki Hirano, Kazuho Kojima, Hongliang Li, Ai Ishikawa, Toru Sakurai, Hong Tai, Takuro Horikoshi, Takashi Uno, Satoshi Kuwabara
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] Cognition related to striatal dopaminergic function in healthy subjects. In consideration to aging (2018)
  • Author(s): Hongliang Li, Shigeki Hirano, Shougo Furakawa, Kazuho Kojima, Keisuke Shimizu , Yoshikazu Nakano, Hong Tai , Hiroki Mukai, Takashi Uno, Takashi Iimori, Hiroshi Matsuda, Satoshi Kuwabara
  • Organizer: International Congress of Parkinson’s Disease and Movement Disorders
  • Int'l Joint Research
• [Presentation] Correlation found between cerebral perfusion and striatal dopamine transporter activity by dual SPECT study in Parkinsonian syndromes (2018)
  • Author(s): Yoshikazu Nakano, Shigeki Hirano, Kazuho Kojima, Hongliang Li, Ai Ishikawa, Toru Sakurai, Hong Tai, Takuro Horikoshi, Takashi Uno, Satoshi Kuwabara
  • Organizer: International Congress of Parkinson’s Disease and Movement Disorders
  • Int'l Joint Research
• [Presentation] Diagnostic value of sStriatal- prefrontal projection estimated by cerebral blood flow and dopamine transporter SPECT in Parkinsonian syndromes. (2017)
  • Author(s): Yoshikazu Nakano, Shigeki Hirano, Kazuho Kojima, Hongliang Li, Ai Ishikawa, Tor Sakurai, Hong Tai, Takuro Horikoshi, Takashi Uno, Satoshi Kuwabara
  • Organizer: 22nd World Congress of Parkinson's Disease and Related Disorders
  • Int'l Joint Research
• [Presentation] パーキンソン症候群における脳血流SPECT画像およびDATSPECT画像を用いた前頭葉線条体連関の診断能 (2017)
  • Author(s): 仲野義和、平野成樹、小島一歩、李洪亮、石川愛、櫻井透、Tai Hong、桑原聡
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス
• [Presentation] 脳血流SPECTを用いたパーキンソン病の抑うつ症状に関与する機能解剖探索 (2017)
  • Author(s): 平野成樹、仲野義和、石川愛、清水啓介 、小島一歩、李洪亮、櫻井透、劉韋氷、山中義崇、山本達也、桑原 聡
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス
• [Presentation] FP-CIT SPECTを用いた、パーキンソン病における抑うつ症状の病態研究 (2017)
  • Author(s): 石川愛、仲野義和、平野成樹、李洪亮、小島一歩、劉韋氷、Tai Hong、櫻井透、桑原聡
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス
• [Presentation] Reduced prefrontal perfusion and decreased striatal dopamine transporter activity are associated with pain symptom in Parkinson’s disease patients  (2017)
  • Author(s): Yoshikazu Nakano, Shigeki Hirano, Kazuho Kojima, Ai Ishikawa, Hongliang Li, Hong Tai, Toru Sakurai, Hiroki Mukai, Takashi Uno, Satoshi Kuwabara
  • Organizer: 23rd World Congress of Neurology
  • Invited