Development of touch panel-type assessment system for driving ability using motion stimuli

• Project/Area Number: 17K09801
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: Yamasaki Takao 九州大学, 医学研究院, 共同研究員 (70404069)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: アルツハイマー型認知症 / 軽度認知障害 / タッチパネルシステム / オプティックフロー / バイオマーカー / 運転能力評価 / 認知症 / タッチパネル式タブレット端末 / 運転 / 運動視 / タッチパネル

Outline of Final Research Achievements

In this study, we have developed “optic flow (OF) cognitive test system using touch panel tablet” as an early diagnosis and driving ability evaluation method for dementia that can be easily performed anywhere in a short time. With this system, the OF cognitive threshold can be examined using two-alternative forced choice paradigm. The OF cognitive threshold can be calculated automatically. We have found that patients with mild cognitive impairment (MCI) and early stage of Alzheimer's disease (AD) have higher OF cognitive thresholds than healthy elderly. Therefore, we believe that the portable touch panel system using OF motion is useful for the early detection and driving ability evaluation of MCI and early AD patients in the community-dwelling elderly populations.

Academic Significance and Societal Importance of the Research Achievements

タブレット端末を用いた認知機能検査は市販されているが，疾患特異性に乏しい．一方，本装置はADが原因であるMCI患者で特異的に異常を示すOF認知に着目して開発したものであり，学術的意義は非常に大きい．また，本装置はどこででも短時間で簡便に施行できるので，地域在住の高齢者集団における認知症の早期診断・運転能力評価法として有用であり，社会的意義も大きい．

Research Products

• [Journal Article] Use of VEPs as electrodiagnostic biomarkers of mild cognitive impairment (2020)
  • Author(s): Yamasaki T
  • Journal Title: Neurology and Clinical Neuroscience Volume: in press Issue: 1 Pages: 3-9
  • DOI: 10.1111/ncn3.12387
  • Peer Reviewed
• [Journal Article] Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment: An fMRI study. (2019)
  • Author(s): Yamasaki T, Aso A, Kaseda Y, Mimor Y, Doi H, Matsuoka N, Takamiya N, Torii T, Takahashi T, Ohshita T, Yamashita H, Doi H, Inamizu S, Chatani H, Tobimatsu S
  • Journal Title: Neuroscience Letters Volume: 711 Pages: 134402-134402
  • DOI: 10.1016/j.neulet.2019.134402
  • Peer Reviewed / Open Access
• [Journal Article] Driving Ability in Alzheimer Disease Spectrum: Neural Basis, Assessment, and Potential Use of Optic Flow Event-Related Potentials. (2018)
  • Author(s): Yamasaki T, Tobimatsu S
  • Journal Title: Front Neurol Volume: 9 Pages: 750-750
  • DOI: 10.3389/fneur.2018.00750
  • Peer Reviewed / Open Access
• [Presentation] Altered oscillatory V1 activity to motion perception in patients with mild cognitive impairment: An fMRI study (2019)
  • Author(s): Yamasaki T, Aso T, Kaseda Y, Mimori Y, Doi H, Matsuoka N, Takamiya N, Torii T, Takahashi T, Ohshita T, Yamashita H, Doi H, Inamizu S, Chatani H, Tobimatsu S
  • Organizer: The 13th CME International Conference on Complex Medical Engineering
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 能力判定装置、能力判定方法、及びコンピュータ読み取り可能な記憶媒体 (2019)
  • Inventor(s): 飛松省三，山﨑貴男
  • Industrial Property Rights Holder: 飛松省三，山﨑貴男
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-101022
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] タッチパネル式のオプティックフロー認知検査装置（プログラム） (2019)
  • Inventor(s): 山崎貴男、飛松省三
  • Industrial Property Rights Holder: 山崎貴男、飛松省三
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019