Development of treatment strategy for epilepsy in the elderly
| Project/Area Number |
17K09808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
Naoki Akamatsu 国際医療福祉大学, 医学部, 教授 (10299612)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | てんかん / 側頭葉 / 抗てんかん薬 / 脳波 / 高齢者 / 焦点意識減損発作 / 有病率 / レセプト / 焦点発作 / 意識減損 / 認知症 / 側頭葉てんかん / 臨床神経生理学 / 医療・福祉 |
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| Outline of Final Research Achievements |
The present study revealed that the prevalence of epilepsy in the elderly is 10.3 per 1000 in Hisayama town of Japan. Based on the nationwide retrospective cohort study using a hospital-based medical information database, 44% of epilepsy patients in Japan were aged 65 or above. The clinical characteristics of epilepsy in the elderly includes 1) focal impaired awareness seizure of temporal lobe onset are common, 2) life-style related disorders are prevalent 3) high diagnostic sensitivity of electroencephalography with sleep recording, and 4) higher responsiveness to anti-seizure medication. The present study contribute not only to clinicians to diagnose and treat patients but also to plan health care polycy in the elderly.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで本邦の有病率の研究はほとんどなかった。成人てんかん特に高齢者てんかんの実数把握ができるデータを得たことは、今後のてんかんの臨床および医療政策に貢献できる。高齢者てんかんの症状、検査所見、診断のポイントを本研究で明らかにした。この知見から一般臨床医が的確に高齢者てんかんを診断し治療できるようになる。診療ガイドライインの策定の基礎的データを得ることができた。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Commentary: From theory to practice: Critical points in the 2017 ILAE classification of epileptic seizures and epilepsies2020
Author(s)
Andre Palmini, Naoki Akamatsu, Thomas Bast, Sebastian Bauer, Christoph Baumgartner, Selim Benbadis, Adriana Bermeo‐Ovalle, Stefan Beyenburg, Andrew Bleasel, Alireza Bozorgi et al., and Riki Matsumoto
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Journal Title
Epilepsia
Volume: 61
Issue: 2
Pages: 350-353
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Accelerated long-termf orgetting with temporal lobe epilepsy: MRI volumetric findings2019
Author(s)
Mukaino T, Uehara T, Yokoyama J, Okadome T, Arakawa T, Yokoyama S, Akamatsu N, Shigeto H, Kira J.
Organizer
33rd International Congress of Epilepsy, Bangkok, Thailand
Related Report
Int'l Joint Research
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[Book] 新臨床内科学2020
Author(s)
赤松直樹
Total Pages
4
Publisher
医学書院
ISBN
9784260038072
Related Report
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