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Development of treatment strategy for epilepsy in the elderly

Research Project

Project/Area Number 17K09808
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Naoki Akamatsu  国際医療福祉大学, 医学部, 教授 (10299612)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsてんかん / 側頭葉 / 抗てんかん薬 / 脳波 / 高齢者 / 焦点意識減損発作 / 有病率 / レセプト / 焦点発作 / 意識減損 / 認知症 / 側頭葉てんかん / 臨床神経生理学 / 医療・福祉
Outline of Final Research Achievements

The present study revealed that the prevalence of epilepsy in the elderly is 10.3 per 1000 in Hisayama town of Japan. Based on the nationwide retrospective cohort study using a hospital-based medical information database, 44% of epilepsy patients in Japan were aged 65 or above. The clinical characteristics of epilepsy in the elderly includes 1) focal impaired awareness seizure of temporal lobe onset are common, 2) life-style related disorders are prevalent 3) high diagnostic sensitivity of electroencephalography with sleep recording, and 4) higher responsiveness to anti-seizure medication. The present study contribute not only to clinicians to diagnose and treat patients but also to plan health care polycy in the elderly.

Academic Significance and Societal Importance of the Research Achievements

これまで本邦の有病率の研究はほとんどなかった。成人てんかん特に高齢者てんかんの実数把握ができるデータを得たことは、今後のてんかんの臨床および医療政策に貢献できる。高齢者てんかんの症状、検査所見、診断のポイントを本研究で明らかにした。この知見から一般臨床医が的確に高齢者てんかんを診断し治療できるようになる。診療ガイドライインの策定の基礎的データを得ることができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (35 results)

All 2020 2019 2018 2017

All Journal Article (14 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (18 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Book (3 results)

  • [Journal Article] Commentary: From theory to practice: Critical points in the 2017 ILAE classification of epileptic seizures and epilepsies2020

    • Author(s)
      Andre Palmini, Naoki Akamatsu, Thomas Bast, Sebastian Bauer, Christoph Baumgartner, Selim Benbadis, Adriana Bermeo‐Ovalle, Stefan Beyenburg, Andrew Bleasel, Alireza Bozorgi et al., and Riki Matsumoto
    • Journal Title

      Epilepsia

      Volume: 61 Issue: 2 Pages: 350-353

    • DOI

      10.1111/epi.16426

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Could the 2017 ILAE and the four-dimensional epilepsy classifications be merged to a new “Integrated Epilepsy Classification”?2020

    • Author(s)
      Felix Rosenow, Naoki Akamatsu, Thomas Bast, Sebastian Bauer, Christoph Baumgartner et al., and Riki Matsumoto
    • Journal Title

      Seizure

      Volume: 78 Pages: 31-37

    • DOI

      10.1016/j.seizure.2020.02.018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Classification of paroxysmal events and the four-dimensional epilepsy classification system.2019

    • Author(s)
      Luders H、Vaca GF,、Akamatsu N, et al
    • Journal Title

      Epileptic Disord.

      Volume: 21(1) Pages: 1-29

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Abnormal repolarization: a common electrocardiographic finding in patients with epilepsy.2019

    • Author(s)
      Hayashi K, Kohno R, Akamatsu N, Benditt DG, Abe H
    • Journal Title

      J Cardiovasc Electrophysiol

      Volume: 30 Issue: 1 Pages: 109-115

    • DOI

      10.1111/jce.13746

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of adult epilepsy in a general Japanese population: The Hisayama study2019

    • Author(s)
      Tanaka Akihiro、Hata Jun、Akamatsu Naoki、Mukai Naoko、Hirakawa Yoichiro、Yoshida Daigo、Kishimoto Hiro、Ohara Tomoyuki、Mizuno Toshiki、Tsuji Sadatoshi、Kitazono Takanari、Ninomiya Toshiharu
    • Journal Title

      Epilepsia Open

      Volume: 4 Issue: 1 Pages: 182-186

    • DOI

      10.1002/epi4.12295

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Critique of the 2017 epileptic seizure and epilepsy classifications2019

    • Author(s)
      Hans Luders, Naoki Akamatsu, Shahram Amina, Christoph Baumgartner, Selim Benbadis et al. and Riki Matsumoto
    • Journal Title

      Epilepsia

      Volume: 60 Issue: 6 Pages: 1032-1039

    • DOI

      10.1111/epi.14699

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 高齢者に対する抗てんかん薬の臨床2019

    • Author(s)
      赤松直樹
    • Journal Title

      老年精神医学雑誌

      Volume: 30 Pages: 1399-1404

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] リハビリテーション医療に必要な薬物治療2019

    • Author(s)
      赤松直樹
    • Journal Title

      総合リハビリテーション

      Volume: 47 Pages: 1236-1239

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 高齢者てんかんの特徴と対処法2019

    • Author(s)
      赤松直樹
    • Journal Title

      日本医師会雑誌

      Volume: 148 Pages: 1731-1733

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 妊産褥婦の合併疾患の対処法-てんかん2019

    • Author(s)
      赤松直樹
    • Journal Title

      産婦人科救急当直対応マニュアル、臨床婦人科産科

      Volume: 173 Pages: 332-335

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 結節性硬化症-疾患の正しい理解の必要性と適切な診療連携・移行医療(トランジション)のありかた2019

    • Author(s)
      池田昭夫、赤松直樹
    • Journal Title

      脳神経内科

      Volume: 91 Pages: 270-277

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 高齢者のてんかん、てんかん基礎講座2019

    • Author(s)
      赤松直樹
    • Journal Title

      波

      Volume: 43 Pages: 32-33

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 高齢者てんかん診療の課題はまず正しい知識の普及から2019

    • Author(s)
      赤松直樹
    • Journal Title

      Progress in Medicine

      Volume: 39 Pages: 1057-1058

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 認知症と高齢発症てんかん2018

    • Author(s)
      赤松直樹
    • Journal Title

      老年精神医学雑誌

      Volume: 29 Pages: 68-73

    • Related Report
      2017 Research-status Report
  • [Presentation] Elderly epilepsy and comorbidity2019

    • Author(s)
      Akamatsu N
    • Organizer
      The 3rd China Association Against Epilepsy Comorbidity Conference, Zhengzhou
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epilepsy and challenges of longevity2019

    • Author(s)
      Akamatsu N
    • Organizer
      33rd International Congress of Epilepsy
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Prevalence of elderly epilepsy in a general Japanese population: the Hisayama study.2019

    • Author(s)
      Akamatsu N
    • Organizer
      12th International Epilepsy Colloquium, Lion, France
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Predictors of postsurgical seizure relapse and post-relapse after surgery of temporal lobe epilepsy in the era of new antiepileptic drugs2019

    • Author(s)
      Tanaka H, Shigeto H, Ohara S, Matsushima T, Inoue T, Akamatsu N,
    • Organizer
      33rd International Congress of Epilepsy, Bangkok, Thailand
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of adult epilepsy in a general Japanese population: the Hisayama study.2019

    • Author(s)
      Tanaka A, Hata J, Akamatsu N, Mizuno T, Ninomiya T
    • Organizer
      33rd International Congress of Epilepsy, Bangkok, Thailand
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accelerated long-termf orgetting with temporal lobe epilepsy: MRI volumetric findings2019

    • Author(s)
      Mukaino T, Uehara T, Yokoyama J, Okadome T, Arakawa T, Yokoyama S, Akamatsu N, Shigeto H, Kira J.
    • Organizer
      33rd International Congress of Epilepsy, Bangkok, Thailand
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] てんかん患者に認められる頭痛2019

    • Author(s)
      赤松直樹
    • Organizer
      第60回日本神経学会学術大会、教育コース講演
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 抗てんかん薬の断薬2019

    • Author(s)
      赤松直樹
    • Organizer
      第53回日本てんかん学会、シンポジウム小児てんかんの断薬
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 認知症とてんかん2019

    • Author(s)
      赤松直樹
    • Organizer
      第38回日本認知症学会学術集会 教育講演
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ときめき感のアウラを呈した側頭葉てんかんの一例2019

    • Author(s)
      吉村玲、赤松直樹、三好絢子、田中秀明、神崎由紀、谷脇予志秀、大原信司、重藤寛史、
    • Organizer
      第225回日本神経学会九州地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 外来脳波の側頭葉てんかん診断における睡眠賦活の有用性2019

    • Author(s)
      文室知之、肥田まどか、平木景子、當間淳也、吉川暉人、赤松直樹
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 頭蓋内脳波モニタリングを行った難治性てんかんの一例2019

    • Author(s)
      三好絢子、田中秀明、横山淳、鎌田崇嗣、大原信司、赤松直樹、松島敏夫
    • Organizer
      第14回日本てんかん学会九州地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 頭蓋内脳波モニタリングを行った難治性てんかんの手術2019

    • Author(s)
      三好絢子、田中秀明、横山淳、鎌田崇嗣、大原信司、赤松直樹、松島敏夫
    • Organizer
      第53回日本てんかん学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 空間注意と運動準備段階で発生する脳電位変化の関係:頭蓋内電極を用いた検討2019

    • Author(s)
      文室知之、池田昭夫、赤松直樹
    • Organizer
      第45回日本臨床神経生理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 定位的深部脳波(SEEG)を用いて扁桃体に限局したてんかん発作波を同定し得た口部自動症発作の一例2019

    • Author(s)
      萩原綱一、三好絢子、鎌田崇嗣、大原信司、重藤寛史、赤松直樹
    • Organizer
      第228回日本神経学会九州地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Epidemiology of Epilepsy Patients and Comparison with Non-Epilepsy Patients Using a Large Claims Database in Japan2018

    • Author(s)
      Naoki Akamatsu, Hisashi Urushihara, Kasumi Daidoji, Kenta Sumitomo, Eisei Oda, Masaki Nakamura, Mika Ishii.
    • Organizer
      12th Asia Oceanian Epilepsy Congress
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 高齢者のてんかん2018

    • Author(s)
      赤松直樹
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 最新の抗てんかん薬治療2017

    • Author(s)
      赤松直樹
    • Organizer
      平成28年度日本神経学会九州地区生涯教育講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 今日の診断指針 第8版2020

    • Author(s)
      赤松直樹
    • Total Pages
      4
    • Publisher
      医学書院
    • ISBN
      9784260038089
    • Related Report
      2019 Annual Research Report
  • [Book] 新臨床内科学2020

    • Author(s)
      赤松直樹
    • Total Pages
      4
    • Publisher
      医学書院
    • ISBN
      9784260038072
    • Related Report
      2019 Annual Research Report
  • [Book] 今日の治療指針、福井次矢他総編集 てんかんの内科治療、2019

    • Author(s)
      赤松直樹
    • Publisher
      医学書院
    • ISBN
      9784260036504
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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