Physiological biomarker of Parkinsonian symptoms using neuroplasticity function in humans
| Project/Area Number |
17K09809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宇川 義一 福島県立医科大学, 医学部, 教授 (50168671)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経可塑性 / 非侵襲的脳刺激法 / 神経変性疾患 / パーキンソン病 / 非侵襲脳刺激法 / 4連発磁気刺激法 / 抗パーキンソン病薬 / 脳・神経 / 神経疾患 / 神経生理 |
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| Outline of Final Research Achievements |
In the present study, we analyzed neural plasticity of the human motor cortex in neurodegenerative disorders, using quadripulse magnetic stimulation (QPS), one of non-invasive brain stimulation techniques. Cortical plasticity induction by QPS decreased in Off state of Parkinson’s disease and restored by L-dopa. The degree of cortical plasticity was shown to negatively relate with the degree of parkinsonian symptoms, indicating with motor scores of unified Parkinson’s disease rating scale (UPDRS). In progressive nuclear palsy (PSP), one of atypical parkinsonian syndrome, induction of cortical plasticity was impaired. These findings indicate that cortical plasticity may reflect patho-mechanisms for parkinsonian symptoms.
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| Academic Significance and Societal Importance of the Research Achievements |
神経変性疾患の症状には発症機序がまだ不明なものが多い。非侵襲的脳刺激を用いてヒトの大脳皮質においても誘導できるようになった神経可塑性が、神経変性疾患で誘導が障害されており、パーキンソン病の症状とも関連があることが示されたことにより、症状の発症機序の解明につなげることができると考えられる。また、症状を客観的に捉えるバイオマーカーや、鑑別診断のためのバイオマーカーとして役立てられる可能性が示唆される。
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Effects of L-DOPA on quadripulse magnetic stimulation-induced long-term potentiation in older adults. Neurobiology of Aging 84: 217-224, 20192019
Author(s)
Tanaka N, Tsutsumi R, Shirota Y, Shimizu T, Ohminami S, Terao Y, Ugawa Y, Tsuji S, Hanajima R
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Journal Title
Neurobiology of Aging 84: 217-224, 2019
Volume: 84
Pages: 217-224
DOI
Related Report
Peer Reviewed
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[Journal Article] An Essential Role of the Intraparietal Sulcus in Response Inhibition Predicted by Parcellation-Based Network.2019
Author(s)
Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S.
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Journal Title
J Neurosci.
Volume: 39
Issue: 13
Pages: 2509-2521
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effect of age on the homotopic motor cortical long-term potentiation-like effect induced by quadripulse stimulation2017
Author(s)
Hanajima R, Tanaka N, Tsutsumi R, Enomoto H, Abe M, Nakamura K, Kobayashi S, Hamada M, Shimizu T, Terao Y, Ugawa Y
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Journal Title
Exp Brain Res
Volume: 印刷中
Issue: 7
Pages: 2103-2108
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Genetic anticipation and clinical features of thirty two patients with benign adult familial myoclonic epilepsy (BAFME).2017
Author(s)
Matsukawa M, Ishiura H, Ichikawa Y, Higashihara M, Sakiyama Y, Otsuka M, Ueki A, Kaida K, Tanaka M, Takahashi Y, Mitsui J, Matsukawa T, Hanajima R, Hayashi T, Terao Y, Inomata-Terada S, Hamada M, hirota Y, Kubota A, Tsuji S
Organizer
World Congress of Neurology
Related Report
Int'l Joint Research
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