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Physiological biomarker of Parkinsonian symptoms using neuroplasticity function in humans

Research Project

Project/Area Number 17K09809
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionTottori University

Principal Investigator

HANAJIMA Ritsuko  鳥取大学, 医学部, 教授 (80396738)

Co-Investigator(Kenkyū-buntansha) 宇川 義一  福島県立医科大学, 医学部, 教授 (50168671)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経可塑性 / 非侵襲的脳刺激法 / 神経変性疾患 / パーキンソン病 / 非侵襲脳刺激法 / 4連発磁気刺激法 / 抗パーキンソン病薬 / 脳・神経 / 神経疾患 / 神経生理
Outline of Final Research Achievements

In the present study, we analyzed neural plasticity of the human motor cortex in neurodegenerative disorders, using quadripulse magnetic stimulation (QPS), one of non-invasive brain stimulation techniques. Cortical plasticity induction by QPS decreased in Off state of Parkinson’s disease and restored by L-dopa. The degree of cortical plasticity was shown to negatively relate with the degree of parkinsonian symptoms, indicating with motor scores of unified Parkinson’s disease rating scale (UPDRS). In progressive nuclear palsy (PSP), one of atypical parkinsonian syndrome, induction of cortical plasticity was impaired. These findings indicate that cortical plasticity may reflect patho-mechanisms for parkinsonian symptoms.

Academic Significance and Societal Importance of the Research Achievements

神経変性疾患の症状には発症機序がまだ不明なものが多い。非侵襲的脳刺激を用いてヒトの大脳皮質においても誘導できるようになった神経可塑性が、神経変性疾患で誘導が障害されており、パーキンソン病の症状とも関連があることが示されたことにより、症状の発症機序の解明につなげることができると考えられる。また、症状を客観的に捉えるバイオマーカーや、鑑別診断のためのバイオマーカーとして役立てられる可能性が示唆される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (34 results)

All 2020 2019 2018 2017

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Int'l Joint Research: 11 results,  Invited: 8 results)

  • [Journal Article] Plasticity induction in the pre-supplementary motor area (pre-SMA) and SMA-proper differentially affects visuomotor sequence learning2020

    • Author(s)
      Shimizu Takahiro、Hanajima Ritsuko、Shirota Yuichiro、Tsutsumi Ryosuke、Tanaka Nobuyuki、Terao Yasuo、Hamada Masashi、Ugawa Yoshikazu
    • Journal Title

      Brain Stimulation

      Volume: 13 Issue: 1 Pages: 229-238

    • DOI

      10.1016/j.brs.2019.08.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Single-institution Study on Predictors of Short-term Progression from Mild Cognitive Impairment in Parkinson’s Disease to Parkinson’s Disease with Dementia2020

    • Author(s)
      Tajiri Y, Wada-Isoe K, Tanaka K, Adachi T, Hanajima R, Nakashima K.
    • Journal Title

      Yonago Acta Medica

      Volume: 63 Issue: 1 Pages: 28-33

    • DOI

      10.33160/yam.2020.02.004

    • NAID

      130007800484

    • ISSN
      0513-5710, 1346-8049
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictors for Incident Mild Parkinsonian Signs in Older Japanese2020

    • Author(s)
      Kishi Masafumi、Wada-isoe Kenji、Hanajima Ritsuko、Nakashima Kenji
    • Journal Title

      Yonago Acta Medica

      Volume: 63 Issue: 1 Pages: 1-7

    • DOI

      10.33160/yam.2020.02.001

    • NAID

      130007800489

    • ISSN
      0513-5710, 1346-8049
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral Venous Thrombosis due to Nontyphoidal <i>Salmonella</i> Bacteremia2019

    • Author(s)
      Taneda K, Adachi T, Watanabe Y, Hanajima R.
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 13 Pages: 1943-1946

    • DOI

      10.2169/internalmedicine.2266-18

    • NAID

      130007672122

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-07-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of L-DOPA on quadripulse magnetic stimulation-induced long-term potentiation in older adults. Neurobiology of Aging 84: 217-224, 20192019

    • Author(s)
      Tanaka N, Tsutsumi R, Shirota Y, Shimizu T, Ohminami S, Terao Y, Ugawa Y, Tsuji S, Hanajima R
    • Journal Title

      Neurobiology of Aging 84: 217-224, 2019

      Volume: 84 Pages: 217-224

    • DOI

      10.1016/j.neurobiolaging.2019.08.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased facilitation of the primary motor cortex in de novo Parkinson's disease2019

    • Author(s)
      Shirota Yuichiro、Ohminami Shinya、Tsutsumi Ryosuke、Terao Yasuo、Ugawa Yoshikazu、Tsuji Shoji、Hanajima Ritsuko
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 66 Pages: 125-129

    • DOI

      10.1016/j.parkreldis.2019.07.022

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supplementary motor area plays a causal role in automatic inhibition of motor responses.2019

    • Author(s)
      Shirota Y, Hanajima R, Ohminami S, Tsutsumi R, Ugawa Y, Terao Y.
    • Journal Title

      Brain Stimul

      Volume: 印刷中 Issue: 4 Pages: 1020-1026

    • DOI

      10.1016/j.brs.2019.03.002

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features of freezing of gait in Parkinson's disease patients2019

    • Author(s)
      Sawada Makoto、Wada-Isoe Kenji、Hanajima Ritsuko、Nakashima Kenji
    • Journal Title

      Brain and Behavior

      Volume: 9 Issue: 4

    • DOI

      10.1002/brb3.1244

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Essential Role of the Intraparietal Sulcus in Response Inhibition Predicted by Parcellation-Based Network.2019

    • Author(s)
      Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S.
    • Journal Title

      J Neurosci.

      Volume: 39 Issue: 13 Pages: 2509-2521

    • DOI

      10.1523/jneurosci.2244-18.2019

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of caffeine on long-term potentiation-like effects induced by quadripulse transcranial magnetic stimulation.2019

    • Author(s)
      Hanajima R, Tanaka N, Tsutsumi R, Shirota Y, Shimizu T, Terao Y, Ugawa Y.
    • Journal Title

      Exp Brain Res.

      Volume: 237 Issue: 3 Pages: 647-651

    • DOI

      10.1007/s00221-018-5450-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A significant correlation between cauda equina conduction time and cerebrospinal fluid protein in chronic inflammatory demyelinating polyradiculoneuropathy.2018

    • Author(s)
      Matsumoto H, Hanajima R, Terao Y, Hamada M, Shirota Y, Yugeta A, Nakatani-Enomoto S, Hashida H, Ugawa Y.
    • Journal Title

      J Neurol Sci.

      Volume: 384 Pages: 7-9

    • DOI

      10.1016/j.jns.2017.11.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of age on the homotopic motor cortical long-term potentiation-like effect induced by quadripulse stimulation2017

    • Author(s)
      Hanajima R, Tanaka N, Tsutsumi R, Enomoto H, Abe M, Nakamura K, Kobayashi S, Hamada M, Shimizu T, Terao Y, Ugawa Y
    • Journal Title

      Exp Brain Res

      Volume: 235 Issue: 7 Pages: 2103

    • DOI

      10.1007/s00221-017-4953-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Impairment of triad conditioned facilitation in amyotrophic lateral sclerosis.2017

    • Author(s)
      Groiss SJ, Mochizuki H, Hanajima R, Trenado C, Nakatani-Enomoto S, Otani K, Ugawa Y.
    • Journal Title

      Amyotroph Lateral Scler Frontotemporal Degener.

      Volume: 7-8 Issue: 7-8 Pages: 604-610

    • DOI

      10.1080/21678421.2017.1321676

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] パーキンソン病患者における4連発磁気刺激法の長期増強様効果への薬物治療の影響2019

    • Author(s)
      守安 正太郎, 清水 崇宏, 本田 誠,宇川 義一,花島 律子
    • Organizer
      第13回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2019 Annual Research Report
  • [Presentation] 進行性核上性麻痺におけるQPSの効果に関する検討2019

    • Author(s)
      本田誠,清水崇宏,守安正太郎,宇川義一,花島律子
    • Organizer
      第49回 日本臨床神経生理学会 学術大
    • Related Report
      2019 Annual Research Report
  • [Presentation] Longitudinal study of PSP rating scale and clinical diagnosis in Progressive supranuclear palsy cases2019

    • Author(s)
      Takigawa H,Ikeuchi T, Aiba I, Morita M,Onodera O,Shimohata T,Tokuda T,Murayama S,o Hasegawa K,Kowa H,Tokumaru A, Hanajima R,Nakashima K,JALPAC study group
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] すくみ足を呈するPD患者のパーソナリティーの検討2019

    • Author(s)
      澤田 誠 和田 健二 中下 聡子 前田 哲也 花島 律子 中島 健二
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] パーキンソン病の大脳の生理学的変化2019

    • Author(s)
      花島律子
    • Organizer
      第13回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 振戦の生理学的検査法2019

    • Author(s)
      花島律子
    • Organizer
      第49回 日本臨床神経生理学会 学術大
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Neurophysiological mechanisms of Parkinison’s disease2019

    • Author(s)
      Hanajima R
    • Organizer
      第60回日本神経学会学術大会 EANF
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Effects of levodopa on LTP-like plasticity induced by quadripulse magnetic stimulation in Parkinson's disease.2019

    • Author(s)
      Moriyasu, S Shimizu T, Honda M, Ugawa Y, Hanajima R
    • Organizer
      Internetional Congress of Parkinson's disease and Movment Disorder
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transcranial Magnetic Stimulation for Movement Disorders2019

    • Author(s)
      Hanajima R
    • Organizer
      SUNSHIN 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Physiological Mechanisms underlying Parkinson’s disease2019

    • Author(s)
      Hanajima R
    • Organizer
      SUNSHIN 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dissociative effects of thyrotropin releasing hormone on cerebellar ataxia and cerebellar adaptation in patients with spinocerebellar degeneration.2018

    • Author(s)
      Takahiro Shimizu, Ritsuko Hanajima, Ryosuke Tsutsumi, Naomi Tominaga, Yoshikazu Ugawa and Kazutoshi Nishiyama
    • Organizer
      Internarional congress of parkinson’s disease and movement disorder
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Further insights into excitatory-inhibitory balance of the primary motor cortex in Parkinson’s disease: a triple-pulse stimulation study2018

    • Author(s)
      Yuichiro Shirota, Yasuo Terao, Yoshikazu Ugawa, Ritsuko Hanajima
    • Organizer
      Internarional congress of parkinson’s disease and movement disorder
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Long-term potentiation like effects induced by quadripulse magnetic stimulation in Parkinson’s disease patients “off” and “on” medication states.2018

    • Author(s)
      Shotaro Takahashi, Takahiro Shimizu, Makoto Honda, Yoshikazu Ugawa, Ritsuko Hanajima
    • Organizer
      3rd International Brain Stimulation Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] SCD・MSA診療ガイドラインとその活用2018

    • Author(s)
      花島律子
    • Organizer
      第59回日本神経学会学術大会シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 本態性振戦は小脳起源である-YES2018

    • Author(s)
      花島律子
    • Organizer
      第12回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Effects of TRH therapy on the prism adaptation task in patients with spinocerebellar degeneration.2017

    • Author(s)
      Shimizu T, Hanajima R, Tsutsumi R, Shimizu K, Nishiyama K, Ugawa Y.
    • Organizer
      Internarional congress of parkinson’s disease and movement disorder
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prism adaptation and cerebellar inhibition were impaired in essential tremor2017

    • Author(s)
      Hanajima R, Tsutsumi R, Shirota Y, Shimizu T, Tanaka N, Ugawa Y.
    • Organizer
      Internarional congress of parkinson’s disease and movement disorder
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of TRH therapy on the prism adaptation task in patients with spinocerebellar degeneration2017

    • Author(s)
      Shimizu T, Hanajima R, Tsutsumi R, Shimizu K, Tominaga N, Ugawa Y, Nishiyama K
    • Organizer
      World Congress of Neurology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Genetic anticipation and clinical features of thirty two patients with benign adult familial myoclonic epilepsy (BAFME).2017

    • Author(s)
      Matsukawa M, Ishiura H, Ichikawa Y, Higashihara M, Sakiyama Y, Otsuka M, Ueki A, Kaida K, Tanaka M, Takahashi Y, Mitsui J, Matsukawa T, Hanajima R, Hayashi T, Terao Y, Inomata-Terada S, Hamada M, hirota Y, Kubota A, Tsuji S
    • Organizer
      World Congress of Neurology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cerebellar functions relating prism adaptation and cerebellar inhibition are impaired in essential tremor2017

    • Author(s)
      Hanajima R, Tsutsumi R, Shirota Y, Shimizu T, Tanaka N, Ugawa Y
    • Organizer
      World Congress of Neurology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒトの小脳機能2017

    • Author(s)
      花島律子
    • Organizer
      第48日本臨床神経生理学会 学術大会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2022-12-28  

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