Ion channel dysfunction and small molecule homeostasis dysregulation in amyotrophic lateral sclerosis
Project/Area Number |
17K09811
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Fukushima Medical University (2018-2019) Juntendo University (2017) |
Principal Investigator |
Kanai Kazuaki 福島県立医科大学, 医学部, 教授 (10375751)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 筋萎縮性側索硬化症 / 軸索興奮特性 / 後天性チャネロパチー / 神経過剰興奮性 / 神経内科学 / チャネロパチー |
Outline of Final Research Achievements |
In patients with amyotrophic lateral sclerosis, we investigated the association between motor axonal excitability abnormality and small molecule expression dysregulation in biological fluids. We divided the patients into two groups (a high value group and a low value group) on the basis of neurophysiological indices that are associated with prognosis. As results, we found several small molecules that were correlated with neurophysiological indices that are associated with prognosis.
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Academic Significance and Societal Importance of the Research Achievements |
これまでもALSにおける有力な病態仮説であったグルタミン酸興奮毒性仮説を説明し得る結果が得られた。またALSにおける新規治療法開発における有力なサロゲートマーカーとなる可能性が示唆され、今後の治療法開発に役立つ可能性が示された。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.2019
Author(s)
J. S. Lee, K. Kanai, M. Suzuki, W. S. Kim, H. S. Yoo, Y. Fu, D-K. Kim, B. C. Jung, M. Choi, K. W. Oh, Y. Li, M. Nakatani, T. Nakazato, S. Sekimoto, M. Furuyama, H. Yoshino, S. Kubo, K. Nishioka, R. Sakai, M. Ueyama, H. Mochizuki, H-J. Lee, S. P. Sardi, G. M. Halliday, Y. Nagai, P. H. Lee, N. Hattori, S-J. Lee
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Journal Title
Brain
Volume: 142
Issue: 9
Pages: 2845-59
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] COQ2 variants in Parkinson's disease and multiple system atrophy.2018
Author(s)
Mikasa M, Kanai K, Li Y, Yoshino H, Mogushi K, Hayashida A, Ikeda A, Kawajiri S, Okuma Y, Kashihara K, Sato T, Kondo H, Funayama M, Nishioka K, Hattori N.
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Journal Title
J Neural Transm (Vienna)
Volume: -
Issue: 6
Pages: 938-944
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Isaacs syndrome: A slow potassium channelopathy caused by autoantibodies?2018
Author(s)
Nakazato T, Tsuji Y, Kanai K, Noto YI, Hoshino Y, Yamashiro K, Yokoyama K, Nishioka K, Shimo Y, Watanabe O, Mizuno T, Hattori N.
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Journal Title
Clin Neurophysiol.
Volume: 129
Issue: 5
Pages: 956-958
DOI
Related Report
Peer Reviewed
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[Presentation] Increased motor axonal persistent sodium currents is associated with rapid regional spreading in amyotrophic lateral sclerosis2017
Author(s)
Kazuaki Kanai, Takanori Yokota, Kazumoto Shibuya, Tadashi Kanouchi, Tomoko Nakazato, Yuta Iwai, Sonoko Misawa, Genko Oyama, Yasushi Shimo, Michitaka Mikasa, Motoki Fujimaki, Yasuhiro Kagamihara, Toshio Shimizu, Nobutaka Hattori, Satoshi Kuwabra
Organizer
The XXIII World Congress of Neurology
Related Report
Int'l Joint Research
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