Head to head comparison of [C-11]PBB3 and [F-18]THK5351 for tau PET imaging
| Project/Area Number |
17K09813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Ishii Kenji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (10231135)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Alzheimer病 / タウイメージング / PET / [C-11]PBB3 / [F-18]THK5351 / 病理 / 画像病理相関 |
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| Outline of Final Research Achievements |
We conduced head-to-head comparison study of two tau PET tracers, [C-11]PBB3 and [F-18]THK5351, in the accumulation to human brain. Seventeen cases were examined and autopsy was obtained in three cases. THK5351 appeared to have binding to monoamineoxidase-B (MAO-B), and the selectivity to tau was limited. However, the binding capability to MAO-B make it possible to visualize neurodegenerative/neuroinflammatory lesions with astrogliosis as hot spot with very high sensitivity. MAO-B imaging may be useful to evaluate the localization of neurodegenerative lesions.
PBB3 seems to have cross accumulation to amyloid beta and sensitivity to bind tau lesion is relatively low, however, it appeared to visualize not only 3R/4R tau lesions, but also 4R tau lesion in PSP and CBD. Therefore, PBB3 has potential advantage to visualize tau accumulation in the amyloid negative (non-Alzheimer) neurodegenerative diseases such as 4R tauopathies.
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| Academic Significance and Societal Importance of the Research Achievements |
タウPET診断薬は、何れも非特異的集積（off-target binding）を有し、感度も十分とは言えない。また、Alzheimer病のタウ描出に優れたトレーサーが必ずしも他のタウオパチーの診断に適しているわけではない。
本研究は、タウPET診断薬にはそれぞれ固有の集積の特徴と意義があり、目的によって使い分ける必要があることを明らかにした。
また、MAO-Bイメージングによるアストロサイト活性化診断は、変性病態の局在をホットスポットとして評価できる優れた診断技術であり、今後病態評価への活用が期待される。
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Metabolic network topology of Alzheimer’s disease and dementia with Lewy bodies generated using fluorodeoxyglucose positron emission tomography.2020
Author(s)
Imai M, Tanaka M, SakataM, Wagatsuma K, Tago T, Toyohara J, Sengoku R, Nishina Y, Kanemaru K, Ishibashi K, Murayama S, Ishii K.
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Journal Title
J Alzheimers Dis
Volume: 73
Issue: 1
Pages: 197-207
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results.2019
Author(s)
Takenoshita N, Shimizu S, Kanetaka H, Sakurai H, Suzuki R, Miwa T, Odawara M, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H
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Journal Title
J Alzheimers Dis.
Volume: 71
Issue: 1
Pages: 261-271
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Glia imaging with 18F-THK5351 as a potential marker for neurodegeneration.2018
Author(s)
Ishii, K., Tago, T., Ishibashi, K., Wagatsuma, K., Sakata, M., Toyohara, J., Sengoku, R., Kanemaru, K., Murayama, S.
Organizer
Alzheimer’s Association International Conference 2018
Related Report
Int'l Joint Research
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[Presentation] 18F-THK5351 PET findings in familial Creutzfeldt-Jakob disease with V180I mutation: a cliniclpathological study.2018
Author(s)
Shiraishi, T., Sengoku, R., Sakashita, Y., Nishina, Y., Ishii, K., Kanemaru, K., Murayama, S.
Organizer
19th International Conference of Neuropathology 2018
Related Report
Int'l Joint Research
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[Presentation] Tau imaging using 11C-PBB3 in clinical variants of Alzheimer’s disease.2017
Author(s)
Imai, M., Ishii, K., Tanaka, M., Ishibashi, K., Wagatsuma, K., Sakata, M., Tago, T., Toyohara, J., Maruno, H., Murayama, S., Shimada, H., Higuchi, M., Suhara, T.
Organizer
Asia Oseania Congress of Nuclear Medicine and Biology 2017
Related Report
Int'l Joint Research
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[Presentation] In vitro characterization of [18F]THK5351 binding to melanin-containing cells.2017
Author(s)
Tago, T., Toyohara, J., Harada, R., Furumoto, S., Okamura, N., Kudo, Y., Takahashi-Fujigasaki, J., Murayama, S., Ishii, K.
Organizer
uropean Association of Nuclear Medicine 2017
Related Report
Int'l Joint Research
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