Elucidation of Regulatory Mechanism of Brown Adipocyte Differentiation and Glucose, Lipid and Energy Metabolism by NFIA
| Project/Area Number |
17K09818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Waki Hironori 東京大学, 医学部附属病院, 准教授 (00466765)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 褐色脂肪細胞 / 転写 / 遺伝子 / 分化 / 肥満 / 糖尿病 / トランスジェニック / ノックアウト / 脂肪細胞 / 脂質 |
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| Outline of Final Research Achievements |
Brown adipose tissue has attracted attention as a therapeutic target for obesity. We discovered that a transcription factor NFIA plays an important role in the regulation of brown-adipocyte-specific gene expression. NFIA knockout mice die within a few weeks after birth due to neurological deficit. By creating adipose-tissue-specific NFIA knockout mice and transgenic mice and by studying regulatory mechanism of NFIA, we elucidated NFIA's role in gene regulation and systemic enegery metabolism and its relation to environment.
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| Academic Significance and Societal Importance of the Research Achievements |
脂肪細胞におけるこれまでのNFIAの知見に加えて、成体の全身のエネルギー代謝と環境因子との関連におけるNFIAの役割を明らかなった点で、肥満やメタボリックシンドローム、２型糖尿病などの疾患の治療に役立つ可能性が示唆された。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.2017
Author(s)
Hiraike Y, Waki H, Yu J, Nakamura M, Miyake K, Nagano G, Nakaki R, Suzuki K, Kobayashi H, Yamamoto S, Sun W, Aoyama T, Hirota Y, Ohno H, Oki K, Yoneda M, White AP, Tseng YH, Cypess AM, Larsen TJ, Jespersen NZ, Scheele C, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T
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Journal Title
Nature cell biology
Volume: 19(9)
Issue: 9
Pages: 1081-1092
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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