Understanding molecular mechanisms controlling incretin-induced beta cell proliferation

• Project/Area Number: 17K09825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Gifu University (2018-2019); Kyoto University (2017)
• Principal Investigator: Daisuke Yabe 岐阜大学, 大学院医学系研究科, 教授 (60378643)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 膵β細胞 / 増殖 / 老化 / シングルセルRNA-Seq / インクレチン / シングルセル解析 / インスリン / エピゲノム

Outline of Final Research Achievements

Heterogeneity of gene expression and rarity of replication hampers molecular analysis of β-cell mass restoration in adult pancreas. Here, we show transcriptional dynamics in a sequence of replication process of the β-cell by single-cell RNA sequencing of islets in young and old mice after partial pancreatectomy, which identified 4 subpopulations of Ins1-expressing β-cells (Clusters 1-4). We identified the Cluster 4 cells as replicating β-cells with high expression of cell proliferation markers. A pseudo-time course analysis demonstrated cell cycle progression with switching expression of cyclins and grasped transient activation of ER stress responders and tumor suppressors, giving fine balance of cell cycle progression and arresting. Motif analysis supported change of gene network was regulated by critical transcription factors.In addition, we developed a novel tool that specifically labels replicating β cells.

Academic Significance and Societal Importance of the Research Achievements

糖尿病は膵β細胞の機能不全および膵β細胞量の低下を病因とし、その克服は世界的に最も重要な課題である。今回、膵β細胞量の制御機構の一部を明らかにすることができ、今後、膵β細胞量を標的にした糖尿病の発症予防および治療法の確立に大きく貢献するものと期待される。

Research Products

• [Int'l Joint Research] University of Geneva Medical School(スイス)
• [Int'l Joint Research] Universit de Geneve(スイス)
• [Int'l Joint Research] University of British Columbia(カナダ)
• [Int'l Joint Research] University of Geneva(Switzerland)
• [Int'l Joint Research] British Columbia University(Canada)
• [Journal Article] Distinctive roles of Rb and p53 in the development of pancreatic neuroendocrine tumors. (2020)
  • Author(s): Yamauchi Y, Kodama Y, Shiokawa M, Kakiuchi N, Marui S, Kuwada T, Sogabe Y, Tomono T, Mima A, Morita T, Matsumori T, Ueda T, Tsuda M, Nishikawa Y, Kuriyama K, Sakuma Y, Ota Y, Maruno T, Uza N, Masuda A, Tatsuoka H, Yabe D, Minamiguchi S, Masui T, Inagaki N, Uemoto S, Chiba T, Seno H
  • Journal Title: Cancer Research Volume: .
  • Peer Reviewed
• [Journal Article] Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half? (2020)
  • Author(s): Liu Y, Kubota S, Iizuka K, Yabe D
  • Journal Title: Journal of Diabetes Investigation Volume: . Issue: 6 Pages: 1422-1425
  • DOI: 10.1111/jdi.13302
  • Peer Reviewed / Open Access
• [Journal Article] Association of glucagon‐like peptide‐1 receptor‐targeted imaging probe with in?vivo glucagon‐like peptide‐1 receptor agonist glucose‐lowering effects (2020)
  • Author(s): Murakami T, Fujimoto H, Fujita N, Hamamatsu K, Yabe D, Inagaki N
  • Journal Title: Journal of Diabetes Investigation Volume: . Issue: 6 Pages: 1448-1456
  • DOI: 10.1111/jdi.13281
  • Peer Reviewed / Open Access
• [Journal Article] Tumor-like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin-induced insulin secretion in obese diabetes: a study of ZFDM rat. (2020)
  • Author(s): Hayami T, Yokoi N, Yamaguchi T, Honda K, Murao N, Takahashi H, Wang S, Seino Y, Kamiya H, Yabe D, Sweet IR, Mizoguchi A, Nakamura J, Seino S
  • Journal Title: J Diabetes Investig Volume: - Issue: 6 Pages: 1434-1447
  • DOI: 10.1111/jdi.13272
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells (2019)
  • Author(s): Usui R, Yabe D, Fauzi M, Goto H, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Kobayashi S, Manebe T, Baba Y, Kurosaki T, Herrera PL, Ogura M, Nagashima K, Inagaki N
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 15562-15562
  • DOI: 10.1038/s41598-019-52048-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dietary instructions focusing on meal-sequence and nutritional balance for prediabetes subjects: An exploratory, cluster-randomized, prospective, open-label, clinical trial (2019)
  • Author(s): Yabe D, Kuwata H, Fujiwara Y, Sakaguchi M, Moyama S, Makabe N, Murotani K, Asano H, Ito S, Mishima H, Takase H, Ota N, Seino Y, Hamamoto Y, Kurose T, Seino Y
  • Journal Title: Journal of Diabetes and its Complications Volume: 33 Issue: 12 Pages: 107450-107450
  • DOI: 10.1016/j.jdiacomp.2019.107450
  • Peer Reviewed / Open Access
• [Journal Article] The journey to understanding incretin systems: Theory, practice and more theory (2019)
  • Author(s): Yabe D, Kuwata H, Seino Y
  • Journal Title: Journal of Diabetes Investigation Volume: 10 Issue: 5 Pages: 1171-1173
  • DOI: 10.1111/jdi.13123
  • Peer Reviewed / Open Access
• [Journal Article] Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion (2019)
  • Author(s): Liu Y, Harashima SI, Wang Y, Suzuki K, Tokumoto S, Usui R, Tatsuoka H, Tanaka D, Yabe D, Harada N, Hayashi Y, Inagaki N.
  • Journal Title: FASEB J. Volume: 33 Issue: 5 Pages: 6239-6253
  • DOI: 10.1096/fj.201801783rr
  • Peer Reviewed / Open Access
• [Journal Article] Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity. (2019)
  • Author(s): Usui R, Yabe D, Seino Y.
  • Journal Title: J Diabetes Investig. Volume: 印刷中 Issue: 4 Pages: 902-905
  • DOI: 10.1111/jdi.13005
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional analysis of β-cell proliferation by a novel mouse model (2019)
  • Author(s): Tokumoto S, Yabe D, Tatsuoka H, Usui R, Fauzi M, Botagarova A, Goto H, Herrera PL, Ogura M, Inagaki N
  • Journal Title: bioRxiv Volume: .
  • DOI: 10.1101/659904
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Safety and tolerability of empagliflozin in East Asian patients with type 2 diabetes: Pooled analysis of phase I-III clinical trials. (2019)
  • Author(s): Yabe D, Yasui A, Ji L, Lee MK, Ma RCW, Chang TJ, Okamura T, Zeller C, Kaspers S, Lee J, Kohler S, Seino Y.
  • Journal Title: J Diabetes Investig. Volume: 10 Issue: 2 Pages: 418-428
  • DOI: 10.1111/jdi.12910
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoglycemia Unawareness in Insulinoma Revealed with Flash Glucose Monitoring Systems (2018)
  • Author(s): Sugawa T, Murakami T, Yabe D, Kashima R, Tatsumi M, Ooshima S, Joo E, Wada K, Yoshizawa A, Masui T, Nakamoto Y, Yamauchi Y, Kodama Y, Iemura Y, Ogura M, Yasoda A, Inagaki N.
  • Journal Title: Internal Medicine Volume: 57 Issue: 23 Pages: 3407-3412
  • DOI: 10.2169/internalmedicine.1173-18
  • NAID: 130007539694
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Mental distress and health-related quality of life among type 1 and type 2 diabetes patients using self-monitoring of blood glucose: A cross-sectional questionnaire study in Japan (2018)
  • Author(s): Tanaka N, Yabe D, Murotani K, Ueno S, Kuwata H, Hamamoto Y, Kurose T, Takahashi N, Akashi T, Matsuoka T, Osonoi T, Minami M, Shimono D, Seino Y, The Positive SMBG Study Group Investigators
  • Journal Title: Journal of Diabetes Investigation Volume: in press Issue: 5 Pages: 1203-1211
  • DOI: 10.1111/jdi.12827
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Clinical Practice Guideline for Diabetes 2016. (2018)
  • Author(s): Haneda M, Noda M, Origasa H, Noto H, Yabe D, Fujita Y, Goto A, Kondo T, Araki E
  • Journal Title: J Diabetes Investig. Volume: 9 Issue: 3 Pages: 657-697
  • DOI: 10.1111/jdi.12810
  • NAID: 120006469171
  • Peer Reviewed / Open Access
• [Journal Article] Case 23-2018: A Man with Episodes of Confusion and Hypoglycemia. (2018)
  • Author(s): Murakami T, Yabe D, Inagaki N.
  • Journal Title: N Engl J Med. Volume: 379 Issue: 19 Pages: 1881-1882
  • DOI: 10.1056/nejmc1811310
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Clinical Practice Guideline for Diabetes 2016. (2018)
  • Author(s): Haneda M, Noda M, Origasa H, Noto H, Yabe D, Fujita Y, Goto A, Kondo T, Araki E.
  • Journal Title: Diabetol Int. Volume: 9 Issue: 1 Pages: 1-45
  • DOI: 10.1007/s13340-018-0345-3
  • NAID: 120006469171
  • Peer Reviewed / Open Access
• [Journal Article] Bullous Pemphigoid associated with Dipeptidyl Peptidase-4 Inhibitors: A Report of Five Cases (2018)
  • Author(s): Yoshiji S, Murakami T, Harashima SI, Ko R, Kashima R, Yabe D, Ogura M, Doi K, Inagaki N.
  • Journal Title: Journal of Diabetes Investigation Volume: 9(2) Issue: 2 Pages: 445-447
  • DOI: 10.1111/jdi.12695
  • NAID: 120006454668
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β-cell function and the achievement of the HbA1c target one year after initiation. (2017)
  • Author(s): Usui R, Sakuramachi Y, Seino Yus, Murotani K, Kuwata H, Tatsuoka H, Hamamoto Y, Kurose T, Seino Yut, Yabe D
  • Journal Title: Journal of Diabetes Investigation Volume: in press Issue: 4 Pages: 822-830
  • DOI: 10.1111/jdi.12773
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between deterioration of HbA1c-lowering effects in DPP-4 inhibitor monotherapy and dietary habits: Retrospective analysis of Japanese individuals with type 2 diabetes (2017)
  • Author(s): Kuwata H, Okamoto S, Seino Yus, Murotani K, Tatsuoka H, Usui R, Hamamoto Y, Kurose T, Seino Yut, Yabe D
  • Journal Title: Journal of Diabetes Investigation Volume: in press Issue: 5 Pages: 1153-1158
  • DOI: 10.1111/jdi.12779
  • Peer Reviewed / Open Access
• [Journal Article] SGLT2 inhibitor use and dietary carbohydrate intake in Japanese individuals with type 2 diabetes: a randomized, open-label, 3-arm parallel comparative exploratory study (2017)
  • Author(s): Yabe D, Iwasaki M, Kuwata H, Haraguchi T, Hamamoto Y, Kurose T, Sumita K, Yamazato H, Kanda S, Seino Y
  • Journal Title: Diabetes Obes Metab Volume: 19 Issue: 5 Pages: 739-743
  • DOI: 10.1111/dom.12848
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The efficacy and safety of sitagliptin as compared with glimepiride in Japanese patients aged 60 years or older with type 2 diabetes mellitus (START-J trial) (2017)
  • Author(s): Terauchi Y, Yamada Y, Ishida H, Ohsugi M, Kitaoka M, Satoh J, Yabe D, Shihara N, Seino Y.
  • Journal Title: Diabetes Obesity and Metabolism Volume: 19(8) Issue: 8 Pages: 1188-1192
  • DOI: 10.1111/dom.12933
  • Peer Reviewed / Open Access
• [Journal Article] Insulinoma with a History of Epilepsy: Still a Possible Misleading Factor in the Early Diagnosis of Insulinoma (2017)
  • Author(s): Murakami T, Yamashita T, Yabe D, Masui T, Teramoto Y, Minamiguchi S, Hirota K, Ogura M, Nagashima K, Inagaki N
  • Journal Title: Internal Medicine Volume: 56 Issue: 23 Pages: 3199-3204
  • DOI: 10.2169/internalmedicine.8932-17
  • NAID: 130006235528
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Presentation] Sphingosine kinase 1-interacting protein (SKIP) is a dual regulator of insulin and incretin. (2019)
  • Author(s): Liu Y, Harashima SI, Wang Y, Suzuki K, Tokumoto S, Tanaka D, Yabe D, Harada N, Hayshi Y, Inagaki N
  • Organizer: 11th Asian Association for the Study of Diabetes Scientific Meeting
  • Int'l Joint Research
• [Presentation] Generation of a Novel Mouse Model to study beta cell proliferation (2019)
  • Author(s): Tokumoto S, Yabe D, Tatsuoka H, Usui R, Fauzi M, Goto H, Ogura M, Inagaki N
  • Organizer: 11th Asian Association for the Study of Diabetes Scientific Meeting
  • Int'l Joint Research
• [Presentation] Differnce in epigenetic regulations between young and old mice explored the mechanisms of beta cell proliferation (2019)
  • Author(s): Tatsuoka H, Yabe D, Sakamoto S, Watanabe A, Usui R, Tokumoto S, Usui R, Ainura B, Otani D, Goto H, Fauzi M, Ogura M, Inagaki N
  • Organizer: 11th Asian Association for the Study of Diabetes Scientific Meeting
  • Int'l Joint Research
• [Presentation] Possible Availability of Glucagon-like peptide-1 receptor (GLP-1R)-targeting imaging to predict GLP1R agonist’s efficacy (2019)
  • Author(s): Murakami T, Fujimoto H, Fujita N, Hamamatsu K, Yabe D, Inagaki N
  • Organizer: 11th Asian Association for the Study of Diabetes Scientific Meeting
  • Int'l Joint Research
• [Presentation] Single Cell RNA-Sequencing Dissects Proliferation of Pancreatic Beta Cells (2019)
  • Author(s): Tatsuoka H, Yabe D, Sakamoto S, Watanabe A, Usui R, Tokumoto S, Usui R, Ainura B, Otani D, Goto H, Fauzi M, Ogura M, Inagaki N
  • Organizer: 78th scientific sessions of the American diabetes association
  • Int'l Joint Research
• [Presentation] Store-Operated Ca2 + Entry Activated by STIM1 Plays an Essential Role in GPR40-Mediated GIIS Potentiation. (2019)
  • Author(s): Usui R, Yabe D, Fauzi M, Goto H, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Kobayashi S, Manabe T, Baba Y, Kurosaki T, Herrera PL, Ogura M, Nagashima K, Inagaki N
  • Organizer: 78th scientific sessions of the American diabetes association
  • Int'l Joint Research
• [Presentation] Generation of a Novel Mouse Model to Study beta-Cell Proliferation. (2019)
  • Author(s): Tokumoto S, Yabe D, Tatsuoka H, Usui R, Fauzi M, Goto H, Ogura M, Inagaki N
  • Organizer: 78th scientific sessions of the American diabetes association
  • Int'l Joint Research
• [Presentation] Sphingosine kinase 1-interacting protein (SKIP) is a dual regulator of insulin and incretin. (2019)
  • Author(s): Liu Y, Harashima SI, Wang Y, Suzuki K, Tokumoto S, Tanaka D, Yabe D, Harada N, Hayshi Y, Inagaki N
  • Organizer: AIBIS2019
  • Int'l Joint Research
• [Presentation] Single Cell RNA-Sequencing Dissects Proliferation of Pancreatic Beta Cells. (2019)
  • Author(s): Tatsuoka H, Yabe D, Sakamoto S, Watanabe A, Usui R, Tokumoto S, Usui R, Ainura B, Otani D, Goto H, Fauzi M, Ogura M, Inagaki N
  • Organizer: AIBIS2019
  • Int'l Joint Research
• [Presentation] Generation of a Novel Mouse Model to Study beta-Cell Proliferation. (2019)
  • Author(s): Tokumoto S, Yabe D, Tatsuoka H, Usui R, Fauzi M, Goto H, Ogura M, Inagaki N
  • Organizer: AIBIS2019（YIA）
  • Int'l Joint Research
• [Presentation] Generation of a Novel Mouse Model to Study beta-Cell Proliferation. (2019)
  • Author(s): Tokumoto S, Yabe D, Tatsuoka H, Usui R, Fauzi M, Goto H, Ogura M, Inagaki N
  • Organizer: 55th Annual Meeting of the European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] The importance of islet, hepatic, and intestinal ChREBP in metabolic disease (2019)
  • Author(s): Kiizuka K, Yabe D
  • Organizer: AIBIS2019
  • Int'l Joint Research
• [Presentation] RNAシークエンスとATACシークエンスを用いた加齢による膵β細胞増殖低下のメカニズムの解析 (2019)
  • Author(s): 龍岡久登、矢部大介、坂本智子、渡辺亮、徳本信介、バタガロワ・アイヌラ、臼井亮太、後藤久典、ファウジ・ムハンマド、小倉雅仁、稲垣暢也
  • Organizer: 第62回日本糖尿病学会年次学術集会
  • Int'l Joint Research
• [Presentation] 細胞周期可視化蛍光プローブFucci2aRを用いた膵β細胞増殖の新規定量法の開発 (2019)
  • Author(s): 徳本信介、矢部大介、龍岡久登、臼井亮太、後藤久典、ファウジ・ムハンマド、バタガロワ・アイヌラ、小倉雅仁、稲垣暢也
  • Organizer: 第62回日本糖尿病学会年次学術集会（YIA）
• [Presentation] 膵β細胞におけるGPR40シグナルに注目したストア依存性カルシウム流入の意義の解明 (2019)
  • Author(s): 井亮太、矢部大介、ファウジ・ムハンマド、バタガロワ・アイヌラ、後藤久典、龍岡久登、田原裕美子、小林静香、真鍋俊也、黒崎知博、ペドロ・ルイス・ヘレラ、小倉雅仁、長嶋一昭、稲垣暢也
  • Organizer: 第62回日本糖尿病学会年次学術集会（YIA）
• [Presentation] Sphingosine kinase 1-interacting proteinはインスリン及びインクレチン分泌の双方の制御因子である (2019)
  • Author(s): 27.劉彦言、原島伸一、王宇、鈴木和代、徳本信介、臼井亮太、龍岡久登、田中大祐、矢部大介、原田範雄、林良敬、稲垣暢也
  • Organizer: 第56回日本臨床分子医学会学術集会
• [Presentation] Macro Nutrients and Long-term Glucose-lowering Effects of DPP-4 Inhibitors in Individuals With Type 2 Diabetes (2018)
  • Author(s): Yabe D, Kuwata H, Seino Y.
  • Organizer: Asia Islet Biology & Incretin Symposium
  • Int'l Joint Research / Invited
• [Presentation] Diabetes patients with coronary heart disease: Target and Drug? Diabetes specialist’s perspectives (2018)
  • Author(s): Yabe D
  • Organizer: Asia Pacific Society of Cardiology Congress 2018 Symposium
  • Int'l Joint Research / Invited
• [Presentation] Keynote: Cardiovascular Effects of Anti-diabetes Drugs: Focusing upon East Asians (2018)
  • Author(s): Yabe D
  • Organizer: Asia Pacific Society of Cardiology Congress 2018 Symposium
  • Int'l Joint Research / Invited
• [Presentation] Current status of type 2 diabetes in Japan (2018)
  • Author(s): Yabe D
  • Organizer: Asia Pacific Society of Cardiology Congress 2018 Symposium
  • Int'l Joint Research / Invited
• [Presentation] Meal sequence, incretin secretion and glycemic control (2018)
  • Author(s): Yabe D
  • Organizer: Diabetes Preventing the Preventables 2018
  • Int'l Joint Research / Invited
• [Presentation] Effects of Dietary Instructions Including Meal-Sequence for Prediabetes Subjects: Comparison with Conventional Approach. (2018)
  • Author(s): Yabe D, Kuwata H, Fujiwara Y, Murotani K, Asano H, Mishima H, Hideto T, Noriyasu O, Seino Y, Hamamoto Y, Kurose T, Seino Y.
  • Organizer: 78th scientific sessions of the American diabetes association, Late breaking abstract
  • Int'l Joint Research
• [Presentation] Factors responsible for progression of microalbuminuria in Japanese patients with type 2 diabetes: Retrospective analysis. (2018)
  • Author(s): Kubota S, Kuwata H, Yabe D, Murotani K, Hamamoto Y, Kurose T, Seino Y.
  • Organizer: 78th scientific sessions of the American diabetes association, Late breaking abstract
  • Int'l Joint Research
• [Presentation] Safety and Tolerability of Empagliflozin in East Asian Patients with Type 2 Diabetes;Pooled Analysis of Phase I-III Clinical Trials (2018)
  • Author(s): Yasui A, Yabe D, Ji L, Lee MK, Ma RC, Chang TJ, Okamura T, Zeller C, Kaspers S, Lee J, Kohler S, Seino Y.
  • Organizer: 78th scientific sessions of the American diabetes association, Late breaking abstract
  • Int'l Joint Research
• [Presentation] Deterioration of HbA1c-Lowering Effects in Dipeptidyl-Peptidase Inhibitor and Dietary Habits in Japanese Type 2 Diabetes-Comparison with That of Metformin. (2018)
  • Author(s): Okamoto S, Kuwata H, Yabe D, Hamamoto Y, Kurose T, Seino Y.
  • Organizer: 78th scientific sessions of the American diabetes association, Late breaking abstract
  • Int'l Joint Research
• [Presentation] ER Ca2+ sensor, stromal interaction molecule 1 (STIM1) plays an important role in GPR40-mediated potentiation of glucose-induced insulin secretion. (2018)
  • Author(s): Usui R, Yabe D, Goto H, Fauzi M, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Ogura M, Nagashima K, Inagaki N.
  • Organizer: Asia Islet Biology & Incretin Symposium
  • Int'l Joint Research
• [Presentation] Effects of Dietary Instructions Including Meal-Sequence in Prediabetes Subjects. (2018)
  • Author(s): Fujita Y, Yabe D, Kuwata H, Fujiwara Y, Murotani K, Asano H, Mishima H, Hideto T, Noriyasu O, Seino Y, Hamamoto Y, Kurose T, Seino Y.
  • Organizer: Asia Islet Biology & Incretin Symposium
  • Int'l Joint Research
• [Presentation] The correlation between anti-GAD antibody titer evaluated by RIA and ELISA kit and pancreatic b-cell function (2018)
  • Author(s): Haraguchi T, Okamoto S, Kuwata H, Hamamoto Y, Yabe D, Seino Y.
  • Organizer: Asia Islet Biology & Incretin Symposium
  • Int'l Joint Research
• [Presentation] The role of ER Ca2+sensor, stromal interaction molecule 1 (STIM1) in GPR40-mediated potentiation of glucose-induced insulin secretion. (2018)
  • Author(s): Usui R, Yabe D, Goto H, Fauzi M, Tokumoto S, Tatsuoka H, Tahara Y, Ogura M, Nagashima K, Inagaki N.
  • Organizer: 54th Annual Meeting of the European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] Safety and Tolerability of Empagliflozin in East Asian Patients with Type 2 Diabetes;Pooled Analysis of Phase I-III Clinical Trials (2018)
  • Author(s): Yabe D, Yasui A, Ji Linong, Lee MK, Ma RC, Chang TJ, Okamura T, Zeller C, Kaspers S, Lee J, Kohler S, Seino Y
  • Organizer: 54th Annual Meeting of the European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] Sarcopenia is associated with decreased insulin secretion and increased arterial stiffness in Japanese elderly patients with type 2 diabetes. (2018)
  • Author(s): Moyama Y, Hamamoto Y, Kuwata H, Kurose T, Yabe D, Seino Y.
  • Organizer: 54th Annual Meeting of the European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] Management of DKD with or without cardiovascular disease (2018)
  • Author(s): Yabe D
  • Organizer: Taipei Diabetes Society Congress
  • Int'l Joint Research / Invited
• [Presentation] 慣習的に摂取する食事内容と糖尿病治療薬の効果 (2018)
  • Author(s): 矢部大介、桑田仁司、清野裕
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] 内因性GLP-1による迷走神経シグナリングと糖尿病・肥満・摂食リズム障害の改善 (2018)
  • Author(s): 矢田俊彦、岩崎有作、徳田雅明、矢部大介、清野裕
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] 膵臓の再生を明らかにするシングルセル遺伝子発現及びマルチオミックス解析 (2018)
  • Author(s): 渡辺亮、中村正裕、龍岡久登、矢部大介、稲垣暢也
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] 慣習的に摂取する食事内容と糖尿病治療薬の効果：DPP-4阻害薬、SGLT2阻害薬 (2018)
  • Author(s): 矢部大介
  • Organizer: 第21日本病態栄養学会年次学術集会
• [Presentation] 膵β細胞機能障害に対する治療戦略 (2017)
  • Author(s): 矢部大介
  • Organizer: 第32回日本糖尿病合併症学会/第23回日本糖尿病眼学会
• [Presentation] 食事療法における「食べる順番」の意義 (2017)
  • Author(s): 矢部大介
  • Organizer: 第90回日本内分泌学会年次学術集会
  • Invited
• [Presentation] Diet and medication in the management of type 2 diabetes: Recent findings in an old couple (2017)
  • Author(s): Daisuke Yabe
  • Organizer: 5th Seoul International Congress of Endocrinology and Metabolism
  • Int'l Joint Research / Invited
• [Presentation] Incretin in the management of Asian type 2 diabetes: what is known and what remains to be investigated (2017)
  • Author(s): Daisuke Yabe
  • Organizer: 3rd Korea Japan Diabetes Forum
  • Int'l Joint Research / Invited
• [Presentation] インクレチンによる糖尿病治療：上市７年で明らかにされたこと、明らかでない課題 (2017)
  • Author(s): 矢部大介
  • Organizer: 第60回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] Incretins and incretin-related drugs in the management of type 2 diabetes: From Asian perspectives (2017)
  • Author(s): Daisuke Yabe
  • Organizer: 9th Asian Association for the Study of Diabetes Scientific Meeting
  • Int'l Joint Research / Invited
• [Presentation] インクレチンUpdate (2017)
  • Author(s): 矢部大介
  • Organizer: 第54回日本糖尿病学会近畿地方会
  • Invited