| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
TYK2 is a gene involved in the interferon signaling against virus infection. We previously reported that TYK2 gene mutation associated with insulin dependent diabetes in human and mice. In the current study, we investigated the association between TYK2 promoter variant (TYK2PV) and insulin secretion in type 2 diabetes patients and those with nonalcoholic fatty liver disease. TYK2PV associated with insulin secretion function of type 2 diabetes. In NAFLD, insulin secretion function associate with development of hepatic fibrosis, and TYK2PV tended to associate with insulin secretion function. TYK2PV and potential virus infection might affect the pathogenesis and insulin secretion function of type 2 diabetes and NAFLD.
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