Downregulation of cPLA2 suppress diabetic nephropathy in diabetic mouse models
| Project/Area Number |
17K09835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
Matsumura Takeshi 熊本大学, 大学院生命科学研究部(医), 准教授 (20398192)
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| Co-Investigator(Kenkyū-buntansha) |
瀬ノ口 隆文 熊本大学, 大学院生命科学研究部(医), 助教 (00530320)
石井 規夫 熊本大学, 病院, 特任助教 (10599111)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 糖尿病性腎症 / 炎症 / マクロファージ / cPLA2 / 糖尿病 / 生体分子 / 糖尿病腎症 |
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| Outline of Final Research Achievements |
It is a important theme that the prevention of diabetic nephropathy in Japan. Protein kinase C and subsequent cPLA2 is involved in the progression of diabetic nephropathy. However, it is unclear that the effect of cPLA2 inhibition on the progression of diabetic nephropathy. We revealed that the lack of cPLA2 suppressed the progression of diabetic nephropathy using cPLA2-deficient diabetic mice. The result suggests that the inhibition of cPLA2 is useful for the management of diabetic nephropathy.
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| Academic Significance and Societal Importance of the Research Achievements |
糖尿病性腎症は、慢性的な髙血糖により引き起こされる糖尿病特有の合併症であり、透析導入の原因として、我が国では1位を占める疾患である。しかし、現時点では血糖コントロール以外での腎症治療として有効な薬物はほとんどなく、早急な対策が必要な疾患である。我々はcPLA2欠損マウスを用いた検討で糖尿病性腎症の進展阻止を引き起こせる新たなターゲット分子としてcPLA2の可能性を見出した。本研究の成果から、毒性の少ないcPLA2阻害薬開発を行うことで、慢性腎不全に悩む多くの糖尿病患者の福音となる可能性が提示された。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Differential predictive factors for cardiovascular events in patients with or without cancer history.2019
Author(s)
Sueta D, Tabata N, Ikeda S, Saito Y, Ozaki K, Sakata K, Matsumura T, Yamamoto-Ibusuki M, Murakami Y, Jodai T, Fukushima S, Yoshida N, Kamba T, Araki E, Iwase H, Fujii K, Ihn H, Kobayashi Y, Minamino T, Yamagishi M, Maemura K, Baba H, Matsui K, Tsujita K.
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Journal Title
Medicine (Baltimore).
Volume: 98
Issue: 44
Pages: e17602-e17602
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of hepatic HSP72 on insulin signaling2019
Author(s)
Kitano Sayaka、Kondo Tatsuya、Matsuyama Rina、Ono Kaoru、Goto Rieko、Takaki Yuki、Hanatani Satoko、Sakaguchi Masaji、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Kai Hirofumi、Araki Eiichi
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Journal Title
American Journal of Physiology-Endocrinology and Metabolism
Volume: 316
Issue: 2
Pages: E305-E318
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis.2018
Author(s)
Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 印刷中
Issue: 5
Pages: 994-1006
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Effects of linagliptin on macrophages and on progression of atherosclerosis in high fat-fed apoE-deficient mice2019
Author(s)
Nishida S, Matsumura T, Senokuchi T, Ishii N, Murakami-Nishida S, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
Organizer
The 11th Scientific Meeting of the Asian Association for the Study of Diabetes
Related Report
Int'l Joint Research
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[Presentation] The Hepatic Role of Heat Shock Protein 72 in the Pathogenesis of Type 2 Diabetes2019
Author(s)
Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Ono K, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E
Organizer
The 79th ADA Scientific Meetng
Related Report
Int'l Joint Research
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[Presentation] Pioglitazone Suppresses Macrophage Proliferation in Apolipoprotein-e Deficient Mice by Activating PPARγ2019
Author(s)
Murakami-Nishida S, Matsumura T, Nishida S, Senokuchi T, Ishi N, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
Organizer
The 79th ADA Scientific Meetng
Related Report
Int'l Joint Research
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[Presentation] Linagliptin induces M2 macrophage polarization and suppresses progression of atherosclerosis in high fat-fed apoE-deficient mice2019
Author(s)
Nishida S, Matsumura T, Senokuchi T, Ishii N, Murakami-Nishida S, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
Organizer
The 79th ADA Scientific Meeting
Related Report
Int'l Joint Research
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[Presentation] Inhibition of DPP-4 suppresses atherosclerotic lesion formation through the regulation of M2 macrophage polarization2019
Author(s)
Yagi Y, Matsumura T, Nishida S, Senokuchi T, Ishii N, Murakami-Nishida S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
Organizer
IDF Congress 2019
Related Report
Int'l Joint Research
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