Mechanism and novel biomarkers for pancreatic beta cell-specific destruction in type 1 diabetes

• Project/Area Number: 17K09852
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kindai University
• Principal Investigator: NOSO Shinsuke 近畿大学, 医学部, 准教授 (90460849)
• Co-Investigator(Kenkyū-buntansha): 池上 博司 近畿大学, 医学部, 教授 (20221062) ; 川畑 由美子 近畿大学, 医学部, 准教授 (80423185) ; 馬場谷 成 近畿大学, 医学部, 講師 (10449837) ; 廣峰 義久 近畿大学, 医学部, 講師 (30460851) ; 伊藤 裕進 近畿大学, 医学部, 講師 (20460850)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 1型糖尿病 / 膵β細胞特異的破壊 / バイオマーカー / １型糖尿病 / 膵β細胞破壊 / HLA / 疾患感受性遺伝子 / 膵島破壊 / 自己免疫 / 膵島

Outline of Final Research Achievements

Type 1 diabetes is an incurable disease characterized by specific destruction of pancreatic beta cells, leading to absolute exhaustion of insulin secretion.　Fulminant, acute-onset, and slowly progressive type 1 diabetes were clinically classified by Japan Diabetes Society. It is still difficult to predict the insulin secretion by exact diagnosis of diabetes at the onset of disease, because the mechanisms and pathogenesis of 3 types of type 1 diabetes is largely unkown. We aimed to clarify the genetic factors of type 1 diabetes to select high-risk individuals who develop insulin-dependent state, and identify novel biomarker of beta-cell destruction at early-stage of disease.

Academic Significance and Societal Importance of the Research Achievements

本邦に特有の１型糖尿病発症に関わる遺伝素因を明らかにすることで病態解明とともにハイリスク症例を選別することが可能となる。また低侵襲で汎用性の高い手法で正確なβ細胞破壊や膵島自己免疫を評価することが可能となれば不確かな病型診断に伴う不適切な治療が是正され血糖の乱高下に伴う急性合併症を抑制し、生活の質を改善するのみならず生産者人口の減少を防ぐことができる。また重篤な慢性合併症の発症が抑制され医療経済的にも社会的貢献度は高い。

Research Products

• [Journal Article] Flash glucose monitoring in type 1 diabetes: A comparison with self‐monitoring blood glucose (2020)
  • Author(s): Babaya Naru、Noso Shinsuke、Hiromine Yoshihisa、Taketomo Yasunori、Niwano Fumimaru、Yoshida Sawa、Yasutake Sara、Kawabata Yumiko、Ikegami Hiroshi
  • Journal Title: Journal of Diabetes Investigation Volume: - Issue: 5 Pages: 1222-1229
  • DOI: 10.1111/jdi.13229
  • Peer Reviewed / Open Access
• [Journal Article] Conditions, pathogenesis, and progression of diabetic kidney disease and early decliner in Japan (2020)
  • Author(s): Yoshida Y, Kashiwabara K, Hirakawa Y, Tanaka T, Noso S, Ikegami H, Ohsugi M, Ueki K, Mita T, Watada H, Koya D, Mise K, Wada J, Shimizu M, Wada T, Ito Y, Narita I, Kashihara N, Nangaku M, Matsuyama Y
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 8 Issue: 1 Pages: 1-8
  • DOI: 10.1136/bmjdrc-2019-000902
  • Peer Reviewed / Open Access
• [Journal Article] Recommendations on the proper use of SGLT2 inhibitors (2020)
  • Author(s): The Committee on the Proper Use of SGLT2 Inhibitors (Abiru N, Ikegami H, Inagaki N, Ueki K, Kaku K, Kadowaki T, Sato S, Seino Y, Haneda M)
  • Journal Title: Diabetology International Volume: 11 Issue: 1 Pages: 1-5
  • DOI: 10.1007/s13340-019-00415-8
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and genetic analysis in a family with familial renal glucosuria: Identification of an N101K mutation in the sodium-glucose cotransporter 2 encoded by a solute carrier family 5 member 2 gene. (2019)
  • Author(s): Sada K, Hidaka S, Imaishi N, Shibata K, Katashima R, Noso S, Ikegami H, Kakuma T, Shibata H.
  • Journal Title: J Diabetes Investig Volume: - Issue: 3 Pages: 573-577
  • DOI: 10.1111/jdi.13157
  • Peer Reviewed / Open Access
• [Journal Article] Contribution of Asian Haplotype of KCNJ18 to Susceptibility to and Ethnic Differences in Thyrotoxic Periodic Paralysis (2019)
  • Author(s): Noso Shinsuke、Babaya Naru、Hiromine Yoshihisa、Ito Hiroyuki、Taketomo Yasunori、Yoshida Sawa、Niwano Fumimaru、Monobe Keisuke、Minohara Tatsuro、Okada Takuya、Tsugawa Mamiko、Kawabata Yumiko、Ikegami Hiroshi
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 104 Issue: 12 Pages: 6338-6344
  • DOI: 10.1210/jc.2019-00672
  • Peer Reviewed / Open Access
• [Journal Article] Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in CSAD/lnc-ITGB7-1 on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes. (2019)
  • Author(s): Kawabata Y, Nishida N, Awata T, Kawasaki E, Imagawa A, Shimada A, Osawa H, Tanaka S, Takahashi K, Nagata M, Yasuda H, Uchigata Y, Kajio H, Makino H, Yasuda K, Kobayashi T, Hanafusa T, Tokunaga K, Ikegami H.
  • Journal Title: Diabetes Volume: 68 Issue: 3 Pages: 665-675
  • DOI: 10.2337/db18-0314
  • NAID: 40022000187
  • Peer Reviewed / Open Access
• [Journal Article] Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The MUSCLES-DM study. (2019)
  • Author(s): Sugimoto K, Tabara Y, Ikegami H, Takata Y, Kamide K, Ikezoe T, Kiyoshige E, Makutani Y, Onuma H, Gondo Y, Ikebe K, Ichihashi N, Tsuboyama T, Matsuda F, Kohara K, Kabayama M, Fukuda M, Katsuya T, Osawa H, Hiromine Y, Rakugi H.
  • Journal Title: J Diabetes Investig. Volume: 10: Issue: 6 Pages: 1471-1479
  • DOI: 10.1111/jdi.13070
  • Peer Reviewed / Open Access
• [Journal Article] Fulminant type 1 diabetes associated with Isolated ACTH deficiency induced by anti-programmed cell death 1 antibody—insight into the pathogenesis of autoimmune endocrinopathy— (2019)
  • Author(s): Okahata S, Sakamoto K, Mitsumatsu T, Kondo Y, Noso S, Ikegami H, Shiba T
  • Journal Title: Endocrine Journal Volume: 66 Issue: 4 Pages: 295-300
  • DOI: 10.1507/endocrj.EJ18-0328
  • NAID: 130007636467
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics and clinical course of type 1 diabetes mellitus related to anti-programmed cell death-1 therapy (2019)
  • Author(s): Yamaguchi M, Imagawa A, Abiru N, Awata T, Ikegami H, Uchigata Y, Oikawa Y, Osawa H, Kajio H, Kawasaki E, Kawabata Y, Kozawa J, Shimada A, Takahashi K, Tanaka S, Chujo D, Fukui T, Miura J, Yasuda K, Yasuda H, Kobayashi T, Hanafusa T
  • Journal Title: Diabetol Int. Volume: 10 Pages: 58-66
  • NAID: 40021806480
  • Peer Reviewed / Open Access
• [Journal Article] Verification That Mouse Chromosome 14 Is Responsible for Susceptibility to Streptozotocin in NSY Mice. (2018)
  • Author(s): Babaya N, Ueda H, Noso S, Hiromine Y, Itoi-Babaya M, Kobayashi M, Fujisawa T, Ikegami H.
  • Journal Title: Int J Endocrinol. Volume: 21 Pages: 7654979-7654979
  • DOI: 10.1155/2018/7654979
  • Peer Reviewed / Open Access
• [Journal Article] Early-Onset Diabetes Mellitus in a Patient With a Chromosome 13q34qter Microdeletion Including IRS2. (2018)
  • Author(s): Babaya N, Noso S, Hiromine Y, Ito H, Taketomo Y, Yamamoto T, Kawabata Y, Ikegami H.
  • Journal Title: J Endocr Soc. Volume: 11 Issue: 10 Pages: 1207-1213
  • DOI: 10.1210/js.2018-00175
  • Peer Reviewed / Open Access
• [Journal Article] Insulin deficiency with and without glucagon: A comparative study between total pancreatectomy and type 1 diabetes. (2018)
  • Author(s): Niwano F, Hiromine Y, Noso S, Babaya N, Ito H, Yasutake S, Matsumoto I, Takeyama Y, Kawabata Y, Ikegami H.
  • Journal Title: J Diabetes Investig. Volume: 9 Issue: 5 Pages: 1084-1090
  • DOI: 10.1111/jdi.12799
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics and clinical course of type 1 diabetes mellitus related to anti-programmed cell death-1 therapy. (2018)
  • Author(s): Baden MY, Imagawa A, Abiru N, Awata T, Ikegami H, Uchigata Y, Oikawa Y, Osawa H, Kajio H, Kawasaki E, Kawabata Y, Kozawa J, Shimada A, Takahashi K, Tanaka S, Chujo D, Fukui T, Miura J, Yasuda K, Yasuda H, Kobayashi T, Hanafusa T
  • Journal Title: Diabetol Int. Volume: 10 Issue: 1 Pages: 58-66
  • DOI: 10.1007/s13340-018-0362-2
  • NAID: 40021806480
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion-weighted magnetic resonance imaging in the pancreas of fulminant type 1 diabetes (2018)
  • Author(s): Tokunaga A, Imagawa A, Nishio H, Hayata S, Shimomura I, Abiru N, Awata T, Ikegami H, Uchigata Y, Oikawa Y, Osawa H, Kajio H, Kawasaki E, Kawabata Y, Kozawa J, Shimada A, Takahashi K, Tanaka S, Chujo D, Fukui T, Miura J, Yasuda K, Yasuda H, Kobayashi T, Hanafusa T
  • Journal Title: Diabetol Int Volume: 9 Issue: 4 Pages: 257-265
  • DOI: 10.1007/s13340-018-0355-1
  • NAID: 40021687155
  • Peer Reviewed / Open Access
• [Journal Article] Effects of dosage and dosing frequency on the efficacy and safety of high-dose metformin in Japanese patients with type 2 diabetes mellitus. (2018)
  • Author(s): Kanto K, Ito H, Noso S, Babaya N, Hiromine Y, Taketomo Y, Toma J, Niwano F, Yasutake S, Kawabata Y, Ikegami H.
  • Journal Title: J Diabetes Investig. Volume: 9 Issue: 3 Pages: 587-593
  • DOI: 10.1111/jdi.12755
  • Peer Reviewed / Open Access
• [Journal Article] Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism. (2017)
  • Author(s): Babaya N, Makutani Y, Noso S, Hiromine Y, Ito H, Taketomo Y, Ueda K, Ushijima H, Komoike Y, Yamazaki Y, Sasano H, Kawabata Y, Ikegami H.
  • Journal Title: BMC Endocr Disord. Volume: 17 Issue: 1 Pages: 74-74
  • DOI: 10.1186/s12902-017-0225-z
  • Peer Reviewed / Open Access
• [Journal Article] A case of fulminant type 1 diabetes mellitus with a precipitous decrease in pancreatic volume, induced by nivolmab for malignant melanoma: analysis of HLA and CTLA4 porymorphism. (2017)
  • Author(s): Ishikawa K, Shono-Saito T, Yamate T, Kai Y, Sakai T, Shimizu F, Yamada Y, Mori H, Noso S, Ikegami H, Kojima H, Tanaka H, Fujiwara S, Hatano Y
  • Journal Title: Eur J Dermatol Volume: 27 Issue: 2 Pages: 184-185
  • DOI: 10.1684/ejd.2016.2923
  • Peer Reviewed / Open Access
• [Journal Article] Common phenotype and different non-HLA genes in Graves' disease and alopecia areata (2017)
  • Author(s): Taketomo Y, Noso S, Babaya M, Hiromine Y, Ito H, Kanto K, Niwano F, Oiso N, Kawada A, Kawabata Y, Ikegami H
  • Journal Title: Hum Immunol Volume: 78 Issue: 2 Pages: 185-189
  • DOI: 10.1016/j.humimm.2016.10.019
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A rare HLA genotype in two siblings with type 1 diabetes in a Japanese family clustered with type 1 diabetes (2017)
  • Author(s): Ina Y, Kawabata Y, Sakamoto R, Sekiguchi N and Ikegami H
  • Journal Title: J Diabetes Investig Volume: 印刷中 Issue: 6 Pages: 762-765
  • DOI: 10.1111/jdi.12628
  • Peer Reviewed / Open Access
• [Presentation] NSYマウスにおけるインスリン分泌不全の責任遺伝子のコンジェニックマウスを用いた解析 (2020)
  • Author(s): 田中紗良、小林美里、長田裕太郎、杉山千尋、原田直樹、大野民生、馬場谷成、池上博司、村井篤嗣、堀尾文彦
  • Organizer: 第34回日本糖尿病・肥満動物学会
• [Presentation] マウスNSY系統のストレプトゾトシン誘発糖尿病感受性遺伝子の解析ーRad50遺伝子のミスセンス変異（p.G200V）についてー (2020)
  • Author(s): 宮坂勇輝、前川智樹、名倉巧真、小林美里、馬場谷成、池上博司、堀尾文彦、大野民生
  • Organizer: 第34回日本糖尿病・肥満動物学会
• [Presentation] Symposium: Genetics “Genetics and pathogenesis of type 1 diabetes” (2019)
  • Author(s): Hiroshi Ikegami
  • Organizer: 11th Annual Meeting of Asian Association for the Study of Diabetes
  • Int'l Joint Research / Invited
• [Presentation] Invited lecture: "Genetics and pathogenesis of type 1 diabetes” (2019)
  • Author(s): Hiroshi Ikegami
  • Organizer: The Xijing Diabetes and Endocrine Forum
  • Int'l Joint Research / Invited
• [Presentation] “Suboptimal glycaemic control globally in all age groups of adults with type 1 diabetes: results of a multinational, observational study (SAGE)” (2019)
  • Author(s): E. Renard, P. Pozzilli, P. Choudhary, A. Peters, H. Ikegami, N. Lali, J. Kesavadev, A.G.D. Vianna, Z. Bosnyak, R. Castro, F. Lauand, V. Pilorget, S. Brette
  • Organizer: 55th Annual Meeting of the European Association for the Society of Diabetes
  • Int'l Joint Research
• [Presentation] 糖尿病治療の理論と実際：メトホルミンを中心に (2019)
  • Author(s): 池上博司
  • Organizer: 第56回日本糖尿病学会関東甲信越地方会
  • Invited
• [Presentation] 指定教育講演 「１型糖尿病の最新知見」 (2019)
  • Author(s): 池上博司
  • Organizer: 第53回糖尿病学の進歩
  • Invited
• [Presentation] 免疫チェックポイント阻害薬使用後に発症する内分泌代謝障害の特徴 (2019)
  • Author(s): 武友保憲、能宗伸輔、馬場谷成、廣峰義久、庭野史丸、吉田左和、當間純子、物部圭介、川畑由美子、池上博司
  • Organizer: 第116回日本内科学会総会・講演会
• [Presentation] 教育講演「１型糖尿病の病態と治療の最前線」 (2019)
  • Author(s): 池上博司
  • Organizer: 第116回日本内科学会総会・講演会
  • Invited
• [Presentation] 教育講演「１型糖尿病」 (2019)
  • Author(s): 池上博司
  • Organizer: 第91回日本内分泌学会学術集会
  • Invited
• [Presentation] Genome-wide association study of fulminant type 1 diabetes：committee on type 1 diabetes of the Japan Diabetes Society (2019)
  • Author(s): 池上博司，川畑由美子
  • Organizer: 第62回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] Estimated number of patients with type 1 diabetes in Japan (2019)
  • Author(s): 川村智行，西川直子，柚山賀彦，中島直樹，横山徹爾，今川彰久，池上博司，満武巨裕，田嶼尚子
  • Organizer: 第62回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 日本人1型糖尿病の包括的データベースの構築と臨床研究への展開（TIDE-J）（第7報） (2019)
  • Author(s): 梶尾裕，中條大輔，安田和基，霜田雅之，春日雅人，今川彰久，池上博司，大澤春彦，阿比留教生，島田朗，長澤幹，及川洋一，安田尚史，粟田卓也，川﨑英二，高橋和眞，小林哲郎，花房俊昭，岩橋博見，香月健志，福井智康，滝澤壮一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 弟が急性発症１型糖尿病、姉が膵島関連自己抗体複数陽性の耐糖能異常を発症した家系での遺伝学的検討 (2019)
  • Author(s): 錦戸慎平、江藤真美、松尾巴瑠奈、野中文陽、庄司寛章、阿比留教生、能宗伸輔、池上博司、山崎浩則
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] ランチョンセミナー4．１型糖尿病の病態と治療 (2019)
  • Author(s): 池上博司
  • Organizer: 第17回１型糖尿病研究会
  • Invited
• [Presentation] １型糖尿病における残存インスリン分泌能指標としての食事負荷後CPR値 (2019)
  • Author(s): 今村修三、廣峰義久、能宗伸輔、馬場谷成、武友保憲、庭野史丸、物部圭介、安武紗良、川畑由美子、池上博司
  • Organizer: 第17回１型糖尿病研究会
• [Presentation] 教育講演2「1型糖尿病の基礎と臨床」 (2019)
  • Author(s): 池上博司
  • Organizer: 日本糖尿病学会中国四国地方会第57回総会
• [Presentation] 教育講演1「１型糖尿病 Update 2019」 (2019)
  • Author(s): 能宗伸輔
  • Organizer: 第56回日本糖尿病学会近畿地方会
  • Invited
• [Presentation] 抗PD-1抗体薬投与後に発症する１型糖尿病（第2報） (2019)
  • Author(s): 橘恵、今川彰久、日本糖尿病学会１型糖尿病の成因、病態に関する調査研究委員会（池上博司、川畑由美子、阿比留教生、粟田卓也、三浦順之助、及川洋一、島田朗、大澤春彦、梶尾裕、川﨑英二、小澤純二、高橋和眞、中條大輔、福井智康、安田和基、安田尚史、花房俊昭、小林哲郎）
  • Organizer: 第17回１型糖尿病研究会
• [Presentation] シンポジウム５．１型糖尿病研究の最前線 ー多様化する病態と診断上の課題 「１型糖尿病の遺伝素因 Genetic Factors of Type 1 Diabetes」 (2018)
  • Author(s): 能宗伸輔、川畑由美子、池上博司
  • Organizer: 第６１回日本糖尿病学会年次学術集会
• [Presentation] シンポジウム５．１型糖尿病研究の最前線 ー多様化する病態と診断上の課題 「１型糖尿病の遺伝素因 Genetic Factors of Type 1 Diabetes」 (2018)
  • Author(s): 川﨑英二、及川洋一、福井智康、今川彰久、中條大輔、梶尾裕、阿比留教生、粟田卓也、池上博司、内潟安子、大澤春彦、川畑由美子、小澤純二、島田朗、高橋和眞、田中昌一郎、永淵正法、三浦順之助、安田和基、安田尚史、花房俊昭、小林哲郎
  • Organizer: 第６１回日本糖尿病学会年次学術集会
• [Presentation] 日本人１型糖尿病の包括的データベースの構築と臨床研究への展開（TIDE-J）（第6報） (2018)
  • Author(s): 中條大輔、今川彰久、安田和基、阿比留教生、粟田卓也、池上博司、岩橋博見、及川洋一、大澤春彦、香月健志、金重勝博、川﨑英二、島田朗、高橋和眞、長澤幹、福井智康、安田尚史、春日雅人、小林哲郎、花房俊昭、梶尾裕
  • Organizer: 第６１回日本糖尿病学会年次学術集会
• [Presentation] 抗ヒトPD-1抗体投与後に発症する１型糖尿病に関する疫学調査 (2018)
  • Author(s): 馬殿恵、今川彰久、阿比留教生、粟田卓也、池上博司、内潟安子、及川洋一、大澤春彦、梶尾裕、川﨑英二、川畑由美子、小澤純二、島田朗、高橋和眞、田中昌一郎、中條大輔、永淵正法、福井智康、三浦順之助、安田和基、安田尚史、小林哲郎、花房俊昭
  • Organizer: 第６１回日本糖尿病学会年次学術集会
• [Presentation] １型糖尿病におけるカーボカウント：糖質インスリン比への体組成の関与 (2018)
  • Author(s): 安武紗良、廣峰義久、能宗伸輔、馬場谷成、伊藤裕進、庭野史丸、物部圭介、幕谷由佳子、川畑由美子、池上博司
  • Organizer: 第115回日本内科学会総会・講演会
• [Presentation] Keynote lecture: Pathogenesis and treatment of insulin-dependent state (2018)
  • Author(s): Hiroshi Ikegami
  • Organizer: 2018 中国西京糖尿病内分泌学術年会
  • Invited
• [Presentation] Identification of genetic loci linked to type 1 diabetes susceptibility by linkage analysis with whole exome sequencing in clustered family (2017)
  • Author(s): Noso S, Hosomichi K, Babaya N, Hiromine Y, Kawabata Y, Ikegami H
  • Organizer: Immunology of Diabetes Society, 15th International Congress 2017
  • Int'l Joint Research
• [Presentation] Whole-exome sequencing in rare families identified novel genetic variants for familial type 1 diabetes (2017)
  • Author(s): Noso S, Hosomichi K, Babaya N, Hiromine Y, Ito H, Taketomo Y, Kawabata Y, Ikegami H
  • Organizer: 53rd Annual Meeting of European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] Insulin dependency with and without glucagon: marked difference in insulin requirement between patients with total pancreatectomy and type 1 diabetes (2017)
  • Author(s): Hiromine Y, Noso S, Babaya N, Ito H, Niwano F, Matsumoto I, Takeyama Y, Kawabata Y, Ikegami H
  • Organizer: 53rd Annual Meeting of European Association for the Study of Diabetes
  • Int'l Joint Research
• [Book] 糖尿病学２０１９ (2019)
  • Author(s): 池上博司、川畑由美子
  • Total Pages: 158
  • Publisher: 診断と治療社
• [Book] 糖尿病UP・DATE賢島セミナー２０１８ (2019)
  • Author(s): 池上博司
  • Total Pages: 238
  • Publisher: メディカル・ジャーナル社
• [Book] 糖尿病 最新の治療2019－2021 (2019)
  • Author(s): 廣峰義久、池上博司
  • Total Pages: 337
  • Publisher: 南江堂
• [Book] 糖尿病の病態生理イラスト図鑑 病気のしくみ・合併症・治療による変化がわかる (2019)
  • Author(s): 廣峰義久、池上博司
  • Total Pages: 240
  • Publisher: メディカ出版
• [Book] 糖尿病治療のニューパラダイム第４巻 糖尿病に合併する病態とその治療 (2019)
  • Author(s): 加来浩平、宇都宮一典、綿田裕孝、松田昌文、池上博司
  • Total Pages: 271
  • Publisher: 医薬ジャーナル誌
• [Book] 最新 多因子遺伝性疾患研究と遺伝カウンセリング (2018)
  • Author(s): 馬場谷成、池上博司
  • Total Pages: 300
  • Publisher: メディカルドゥ
• [Book] 今日の治療指針 2018年版 (2018)
  • Author(s): 川畑由美子
  • Total Pages: 2066
  • Publisher: 医学書院
• [Remarks] 近畿大学医学部内分泌・代謝・糖尿病内科ホームページ
  • URL: http://www.med.kindai.ac.jp/emdm/