Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
The bone mineral density is regulated by osteoclastic bone resorption and osteoblastic mineralization. It is well known that extracellular factors like hormones and cytokines alter osteoclasts and osteoblasts functions. It seems that pH (the concentration of hydrogen ions) also play the important role in bone metabolism. Proton-sensing G-protein coupled receptors including OGR1, GPR4, TDAG8) are expressed in bone cells. We used differentiated osteoclasts and osteoblasts from pH-receptor bone marrow (BM) cells, and found some pH-receptors are expressed in BM cells and osteoclasts and osteoblasts. pH-receptors have the potential to modify the function or the differentiation of osteoblasts and osteoclast.
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