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The role of pH sensors in bone metabolism

Research Project

Project/Area Number 17K09856
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionGunma University

Principal Investigator

Mogi Chihiro  群馬大学, 生体調節研究所, 助教 (00375528)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordspH / Gタンパク質共役型受容体 / 骨芽細胞 / 破骨細胞 / 骨代謝
Outline of Final Research Achievements

The bone mineral density is regulated by osteoclastic bone resorption and osteoblastic mineralization. It is well known that extracellular factors like hormones and cytokines alter osteoclasts and osteoblasts functions. It seems that pH (the concentration of hydrogen ions) also play the important role in bone metabolism. Proton-sensing G-protein coupled receptors including OGR1, GPR4, TDAG8) are expressed in bone cells. We used differentiated osteoclasts and osteoblasts from pH-receptor bone marrow (BM) cells, and found some pH-receptors are expressed in BM cells and osteoclasts and osteoblasts. pH-receptors have the potential to modify the function or the differentiation of osteoblasts and osteoclast.

Academic Significance and Societal Importance of the Research Achievements

高齢化による運動機能障害は現代の日本が抱える大きな問題である。慢性疾患による局所的な炎症などを原因とした細胞外酸性化を感知するpH受容体と骨代謝の関係について検討を行った本研究は、将来的には骨粗しょう症などの治療につながることが期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2020 2019 2018 2017 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.2020

    • Author(s)
      Sato K, Tobo A, Mogi C, Tobo M, Yamane N, Tosaka M, Tomura H, Im DS, Okajima F.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 17193-17193

    • DOI

      10.1038/s41598-020-74372-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Species-Dependent Enhancement of Ovarian Cancer G Protein-Coupled Receptor 1 Activation by Ogerin.2020

    • Author(s)
      Murakami S, Mochimaru Y, Musha S, Kojima R, Deai M, Mogi C, Sato K, Okajima F, Tomura H.
    • Journal Title

      Zoolog Sci.

      Volume: 37 Issue: 2 Pages: 103-108

    • DOI

      10.2108/zs190106

    • NAID

      210000171197

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism.2020

    • Author(s)
      Sato K, Mogi C, Mighell AJ, Okajima F.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 526 Issue: 4 Pages: 920-926

    • DOI

      10.1016/j.bbrc.2020.04.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of GPR4 in increased <i>growth hormone</i> and <i>prolactin</i> expressions by extracellular acidification in MtT/S cells2020

    • Author(s)
      Musha S, Yoshida S, Murakami S, Kojima R, Deai M, Saso N, Mogi C, Sato K, Okajima F, Tomura H.
    • Journal Title

      Journal of Reproduction and Development

      Volume: 66 Issue: 2 Pages: 175-180

    • DOI

      10.1262/jrd.2019-159

    • NAID

      130007830039

    • ISSN
      0916-8818, 1348-4400
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Molecular Mechanisms of Extracellular Acidification-Induced Intracellular Ca 2+ Increase in LβT2 Cells2019

    • Author(s)
      Kojima R, Horiguchi K, Mochimaru Y, Musha S, Murakami S, Deai M, Mogi C, Sato K, Okajima F, Tomura H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 517 Issue: 4 Pages: 636-641

    • DOI

      10.1016/j.bbrc.2019.07.083

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction.2017

    • Author(s)
      Nagasaka A, Mogi C, Ono H, Nishi T, Horii Y, Ohba Y, Sato K, Nakaya M, Okajima F, Kurose H.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 7812-7812

    • DOI

      10.1038/s41598-017-07573-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR42017

    • Author(s)
      J. Negishi, Y. Omori, M. Shindo, H. Takanashi, S. Musha, S. Nagayama, J. Hirayama, H. Nishina, T. Nakakura, C. Mogi, K. Sato, F. Okajima, Y. Mochimaru, H. Tomura
    • Journal Title

      J. Recept. Signal Transduct. Res.

      Volume: 37 Issue: 4 Pages: 401

    • DOI

      10.1080/10799893.2017.1298130

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 1.Effect of the pH-sensitive G protein-associated receptor OGR1 on the intestinal microbiota2020

    • Author(s)
      Hidekazu Ikeuchi1, Maaya Awata1, Chihiro Mogi2, Takeshi Shimosato3
    • Organizer
      International Union of Microbiological Societies 2020 Daejeon, Korea (IUMS 2020), Fully Virtual Congress, 16(Mon)-20(Fri) November
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2.エナメル質形成不全症の家系から発見されたプロトン感知性受容体OGR1変異体Leu74P 口頭発表2020

    • Author(s)
      佐藤幸市1、茂木千尋1、Alan J. Mighell2、岡島史和3
    • Organizer
      第93回日本生化学会大会 一般演題(2020年9/14-16、パシフィコ横浜)
    • Related Report
      2020 Annual Research Report
  • [Presentation] T cell death associated gene 8 mediates MUC5AC expressions in the ovalbumin-induced asthma model.2018

    • Author(s)
      Hiroaki Tsurumaki, Haruka Saito-Aoki, Chihiro Mogi, Koichi Sato, Takashi Nakakura, Yasuhiko Koga, Masakiyo Yatomi, Makiko Sato, Kunio Dobashi, Fumikazu Okajima and Takeshi Hisada
    • Organizer
      XXIV WORLD CONGRESS OF ASTHMA 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] 動物の事典 第4章 4.3 細胞の情報伝達,細胞相互作用 p162-1652020

    • Author(s)
      末光 隆志 ほか
    • Total Pages
      772
    • Publisher
      朝倉書店
    • ISBN
      9784254171662
    • Related Report
      2020 Annual Research Report
  • [Remarks] 群馬大学生体調節研究所シグナル伝達グループホームページ

    • URL

      https://signal-transduction.imcr.gunma-u.ac.jp/

    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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