| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Although GWAS has reported an association between coronary disease and the LIPA gene, the actual mechanism has not been fully elucidated. Cholesterol ester storage disease (CESD) and Wolman's disease are genetic defects in Lysosomal Acid Lipase (LAL). In adults with CESD, familial hypercholesterolemia (FH) is raised as a differential disease.
We measured LAL activity in blood samples from more than 400 patients with high risk of coronary disease, including FH, and found a positive correlation between LAL activity and findings of coronary arteriosclerosis. A study before and after administration of HMG-CoA inhibitors showed significant changes in LAL activity due to statins, which may be part of the efficacy.
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