Roles of Lysosomal Acid Lipase in Development of Coronary Artery Disease

• Project/Area Number: 17K09859
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kanazawa University
• Principal Investigator: Nohara Atsushi 金沢大学, 保健学系, 研究協力員 (50313648)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Lysosomal acid lipase / 家族性高コレステロール血症 / 冠動脈疾患 / HMG-CoA-reductase阻害薬 / コレステロールエステル化率 / 糖代謝 / ライソゾーム酸性リパーゼ / 動脈硬化症 / 低比重リポ蛋白

Outline of Final Research Achievements

Although GWAS has reported an association between coronary disease and the LIPA gene, the actual mechanism has not been fully elucidated. Cholesterol ester storage disease (CESD) and Wolman's disease are genetic defects in Lysosomal Acid Lipase (LAL). In adults with CESD, familial hypercholesterolemia (FH) is raised as a differential disease.
We measured LAL activity in blood samples from more than 400 patients with high risk of coronary disease, including FH, and found a positive correlation between LAL activity and findings of coronary arteriosclerosis. A study before and after administration of HMG-CoA inhibitors showed significant changes in LAL activity due to statins, which may be part of the efficacy.

Academic Significance and Societal Importance of the Research Achievements

心血管疾患の多くは動脈硬化症を背景としており，脂質代謝異常は特に冠動脈疾患リスクの中核の1つである．しかし脂質代謝の理解は未だ十分に解明されているとは言い難い．本研究は遺伝学的に冠動脈疾患リスクになることが示されているが，機序が不明なままになっているLIPA遺伝子でコードされるLysosomal Acid Lipase(LAL)が，実際の患者においてどのような影響を及ぼしているのかを検討し，その一端を明らかにした．

Research Products

• [Journal Article] Impact of High-Density Lipoprotein Function, Rather Than High-Density Lipoprotein Cholesterol Level, on Cardiovascular Disease Among Patients With Familial Hypercholesterolemia (2023)
  • Author(s): Tada Hayato、Okada Hirofumi、Nohara Atsushi、Toh Ryuji、Harada Amane、Murakami Katsuhiro、Iino Takuya、Nagao Manabu、Ishida Tatsuro、Hirata Ken-ichi、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: Circulation Journal Volume: 87 Issue: 6 Pages: 806-812
  • DOI: 10.1253/circj.CJ-22-0560
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2023-05-25
  • Peer Reviewed
• [Journal Article] Attainment of the low-density lipoprotein cholesterol treatment target and prognosis of heterozygous familial hypercholesterolemia (2023)
  • Author(s): Tada Hayato、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Hayashi Kenshi、Fujino Noboru、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: Atherosclerosis Volume: 371 Pages: 61-66
  • DOI: 10.1016/j.atherosclerosis.2023.03.005
  • Peer Reviewed
• [Journal Article] Impact of Healthy Lifestyle in Patients With Familial Hypercholesterolemia (2023)
  • Author(s): Tada H, Kojima N, Yamagami K, Nomura A, Nohara A, Usui S, Sakata K, Hayashi K, Fujino N, Takamura M, Kawashiri MA
  • Journal Title: JACC Asia Volume: 3 Issue: 1 Pages: 152-160
  • DOI: 10.1016/j.jacasi.2022.10.012
  • Peer Reviewed
• [Journal Article] Whole Exome Sequencing Insufficient for a Definitive Diagnosis of a Patient with Compound Heterozygous Familial Hypercholesterolemia (2022)
  • Author(s): Okada Hirofumi、Tada Hayato、Nomura Akihiro、Nohara Atsushi、Okeie Kazuyasu、Nozue Tsuyoshi、Michishita Ichiro、Takamura Masayuki、Takemura Hirofumi、Kawashiri Masa-aki
  • Journal Title: Internal Medicine Volume: 61 Issue: 19 Pages: 2883-2889
  • DOI: 10.2169/internalmedicine.8989-21
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2022-10-01
  • Peer Reviewed
• [Journal Article] Familial Hypercholesterolemia in Patients with Acute Coronary Syndrome: Genetic Insights from EXPLORE-J (2022)
  • Author(s): Harada-Shiba Mariko、Ako Junya、Hirayama Atsushi、Nakamura Masato、Nohara Atsushi、Sato Kayoko、Murakami Yoshitaka、Koshida Ryusuke、Ozaki Asuka、Arai Hidenori
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 8 Pages: 1201-1212
  • DOI: 10.5551/jat.62989
  • NAID: 130008088102
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-08-01
  • Peer Reviewed
• [Journal Article] Achilles Tendon Thickness Assessed by X-ray Predicting a Pathogenic Mutation in Familial Hypercholesterolemia Gene (2022)
  • Author(s): Tada Hayato、Hori Mika、Matsuki Kota、Ogura Masatsune、Nohara Atsushi、Kawashiri Masa-aki、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 6 Pages: 816-824
  • DOI: 10.5551/jat.62869
  • NAID: 130008060205
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Prevalent Coronary Artery Disease and Undertreatment in Heterozygous Familial Hypercholesterolemia -Real-World Data and “Heterozygous FH Score” from FAME Study- (2022)
  • Author(s): Nohara Atsushi
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 5 Pages: 567-570
  • DOI: 10.5551/jat.ED199
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-05-01
• [Journal Article] Early diagnosis and treatments in childhood are associated with better prognosis in patients with familial hypercholesterolemia (2022)
  • Author(s): Tada Hayato、Kojima Nobuko、Yamagami Kan、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: American Journal of Preventive Cardiology Volume: 12 Pages: 100434-100434
  • DOI: 10.1016/j.ajpc.2022.100434
  • Peer Reviewed
• [Journal Article] Impact of variants of uncertain significance of LDL receptor on phenotypes of familial hypercholesterolemia (2022)
  • Author(s): Tada Hayato、Kojima Nobuko、Yamagami Kan、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Hayashi Kenshi、Fujino Noboru、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: Journal of Clinical Lipidology Volume: 16 Issue: 6 Pages: 863-869
  • DOI: 10.1016/j.jacl.2022.09.007
  • Peer Reviewed
• [Journal Article] Effects of Different Types of Pathogenic Variants on Phenotypes of Familial Hypercholesterolemia (2022)
  • Author(s): Tada Hayato、Kojima Nobuko、Yamagami Kan、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Fujino Noboru、Takamura Masayuki、Kawashiri Masa-Aki
  • Journal Title: Frontiers in Genetics Volume: 13 Pages: 872056-872056
  • DOI: 10.3389/fgene.2022.872056
  • Peer Reviewed
• [Journal Article] Genetic mutations, regression of Achilles tendon thickness, and cardiovascular events among patients with familial hypercholesterolemia (2022)
  • Author(s): Tada Hayato、Okada Hirofumi、Nohara Atsushi、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: Atherosclerosis Volume: 340 Pages: 28-34
  • DOI: 10.1016/j.atherosclerosis.2021.11.031
  • Peer Reviewed
• [Journal Article] Lipid Management and 2-Year Clinical Outcomes in Japanese Patients with Acute Coronary Syndrome: EXPLORE-J (2021)
  • Author(s): Nakamura Masato、Ako Junya、Arai Hidenori、Hirayama Atsushi、Nohara Atsushi、Murakami Yoshitaka、Ozaki Asuka、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 12 Pages: 1307-1322
  • DOI: 10.5551/jat.59543
  • NAID: 130008123361
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-12-01
• [Journal Article] Homozygous Familial Hypercholesterolemia (2021)
  • Author(s): Atsushi Nohara, Hayato Tada, Masatsune Ogura, Sachiko Okazaki, Koh Ono, Hitoshi Shimano, Hiroyuki Daida, Kazushige Dobashi, Toshio Hayashi, Mika Hori, Kota Matsuki, Tetsuo Minamino, Shinji Yokoyama, Mariko Harada-Shiba.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 7 Pages: 665-678
  • DOI: 10.5551/jat.RV17050
  • NAID: 130008060156
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-07-01
  • Peer Reviewed / Open Access
• [Journal Article] JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases (2021)
  • Author(s): Yamagishi Masakazu、Tamaki Nagara、Akasaka Takashi、Ikeda Takanori、Ueshima Kenji、Uemura Shiro、----------------、Kurata Akira、---、Yasuda Satoshi、Yoshino Hideaki、on behalf of the Japanese Circulation Society Working Group
  • Journal Title: Circulation Journal Volume: 85 Issue: 4 Pages: 402-572
  • DOI: 10.1253/circj.CJ-19-1131
  • NAID: 130008003075
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-03-25
  • Peer Reviewed / Open Access
• [Journal Article] The Japanese Society for Apheresis clinical practice guideline for therapeutic apheresis (2021)
  • Author(s): Abe T, Matsuo H, Furuichi K, Furukawa Y, Furuya M, Furuya T, Hanafusa N, Hara W, Harada-Shiba M, Hasegawa M, Hattori N, Hattori M, Hidaka S, Hidaka T, Nohara A, Nomura K, Yamaji K., et al
  • Journal Title: Therapeutic Apheresis and Dialysis Volume: 25 Issue: 6 Pages: 728-876
  • DOI: 10.1111/1744-9987.13749
  • Peer Reviewed
• [Journal Article] Prognostic impact of cascade screening for familial hypercholesterolemia on cardiovascular events (2021)
  • Author(s): Tada H, Okada H, Nomura A, Nohara A, Yamagishi M, Takamura M, Kawashiri MA
  • Journal Title: J Clin Lipidol Volume: in press Issue: 2 Pages: 358-365
  • DOI: 10.1016/j.jacl.2020.12.012
  • Peer Reviewed
• [Journal Article] A Healthy Family of Familial Hypobetalipoproteinemia Caused by a Protein-truncating Variant in the PCSK9 Gene (2020)
  • Author(s): Tada H, Okada H, Nomura A, Nohara A, Takamura M, Kawashiri MA
  • Journal Title: Internal Medicine Volume: 59 Issue: 6 Pages: 783-787
  • DOI: 10.2169/internalmedicine.3737-19
  • NAID: 130007808808
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-03-15
  • Peer Reviewed / Open Access
• [Journal Article] Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action. (2020)
  • Author(s): Representatives of the Global Familial Hypercholesterolemia Community,
  • Journal Title: JAMA Cardiol. Volume: - Issue: 2 Pages: 217-217
  • DOI: 10.1001/jamacardio.2019.5173
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A reassessment of the Japanese clinical diagnostic criteria of familial hypercholesterolemia in a hospital-based cohort using comprehensive genetic analysis (2020)
  • Author(s): Tada Hayato、Okada Hirofumi、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: Practical Laboratory Medicine Volume: 22 Pages: e00180-e00180
  • DOI: 10.1016/j.plabm.2020.e00180
  • Peer Reviewed
• [Journal Article] Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations (2020)
  • Author(s): Kojima Nobuko、Tada Hayato、Usui Soichiro、Sakata Kenji、Hayashi Kenshi、Nohara Atsushi、Inazu Akihiro、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: Clinica Chimica Acta Volume: 507 Pages: 11-16
  • DOI: 10.1016/j.cca.2020.04.003
  • Peer Reviewed
• [Journal Article] A Catalog of the Pathogenic Mutations of LDL Receptor Gene in Japanese Familial Hypercholesterolemia (2020)
  • Author(s): Tada H*, Hori M*(*equal contribution), Nomura A, Hosomichi K, Nohara A, Kawashiri M*, Harada-Shiba M*
  • Journal Title: Journal of Clinical Lipidology Volume: - Issue: 3 Pages: 346-351
  • DOI: 10.1016/j.jacl.2020.03.002
  • Peer Reviewed
• [Journal Article] Rare and Deleterious Mutations in ABCG5/ABCG8 Genes Contribute to Mimicking and Worsening of Familial Hypercholesterolemia Phenotype (2019)
  • Author(s): Tada Hayato、Okada Hirofumi、Nomura Akihiro、Yashiro Satoshi、Nohara Atsushi、Ishigaki Yasushi、Takamura Masayuki、Kawashiri Masa-aki
  • Journal Title: Circulation Journal Volume: 83 Issue: 9 Pages: 1917-1924
  • DOI: 10.1253/circj.CJ-19-0317
  • NAID: 130007695018
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-08-23
  • Peer Reviewed / Open Access
• [Journal Article] Investigation into Lipid Management in Acute Coronary Syndrome Patients from the EXPLORE-J Study (2019)
  • Author(s): Nakamura Masato、Ako Junya、Arai Hidenori、Hirayama Atsushi、Murakami Yoshitaka、Nohara Atsushi、Uno Kiyoko、Ozaki Asuka、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 6 Pages: 559-572
  • DOI: 10.5551/jat.45583
  • NAID: 130007657512
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-06-01
  • Peer Reviewed
• [Journal Article] Safety and Efficacy of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (HoFH): Results from the AEGR-733-301 Long-Term Extension Study (2019)
  • Author(s): Nohara Atsushi、Otsubo Yoshihiko、Yanagi Koji、Yoshida Masayuki、Ikewaki Katsunori、Harada-Shiba Mariko、Jurecka Agnieszka
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 4 Pages: 368-377
  • DOI: 10.5551/jat.45708
  • NAID: 130007621868
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-04-01
  • Peer Reviewed
• [Journal Article] Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease (2019)
  • Author(s): Peloso Gina M.、Nomura Akihiro、Khera Amit V.、Nohara Atsushi、Kawashiri Masa-aki、Tada Hayato、Dewey Frederick E.、Carey David J.、Baras Aris、Kathiresan Sekar et al.
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 12 Issue: 5
  • DOI: 10.1161/circgen.118.002376
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical whole exome sequencing in severe hypertriglyceridemia (2019)
  • Author(s): Tada Hayato、Nomura Akihiro、Okada Hirofumi、Nakahashi Takuya、Nozue Tsuyoshi、Hayashi Kenshi、Nohara Atsushi、Yagi Kunimasa、Inazu Akihiro、Michishita Ichiro、Mabuchi Hiroshi、Yamagishi Masakazu、Kawashiri Masa-aki
  • Journal Title: Clinica Chimica Acta Volume: 488 Pages: 31-39
  • DOI: 10.1016/j.cca.2018.10.041
  • Peer Reviewed / Open Access
• [Journal Article] Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia (2018)
  • Author(s): Tada Hayato、Nomura Akihiro、Nohara Atsushi、Inazu Akihiro、Mabuchi Hiroshi、Yamagishi Masakazu、Kawashiri Masa-aki
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 12 Pages: 1188-1195
  • DOI: 10.5551/jat.44768
  • NAID: 130007539352
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease (2018)
  • Author(s): Tada Hayato、Nohara Atsushi、Inazu Akihiro、Sakuma Nagahiko、Mabuchi Hiroshi、Kawashiri Masa-aki
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 9 Pages: 783-789
  • DOI: 10.5551/jat.RV17024
  • NAID: 130007479708
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Statement for Appropriate Clinical Use of PCSK9 Inhibitors (2018)
  • Author(s): Nohara Atsushi、Ohmura Hirotoshi、Okazaki Hiroaki、Ogura Masatsune、Kitagawa Kazuo、Koseki Masahiro、Sato Kayoko、Tsukamoto Kazuhisa、Yamashita Shizuya、On behalf of the Japan Atherosclerosis Society Working Group on Statement for Appropriate Use of PCSK9 Inhibitors
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 8 Pages: 747-750
  • DOI: 10.5551/jat.45229
  • NAID: 130007429079
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Guidelines for Diagnosis and Treatment of Familial Hypercholesterolemia 2017 (2018)
  • Author(s): Harada-Shiba Mariko、Arai Hidenori、Ishigaki Yasushi、Ishibashi Shun、Okamura Tomonori、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Bujo Hideaki、Miyauchi Katsumi、Yamashita Shizuya、Yokote Koutaro、Working Group by Japan Atherosclerosis Society for Making Guidance of Familial Hypercholesterolemia
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 8 Pages: 751-770
  • DOI: 10.5551/jat.CR003
  • NAID: 130007429791
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia (2018)
  • Author(s): Okada H, Tada H, Hayashi K, Kawashima H, Takata T, Sakata K, Nohara A, Mabuchi H, Yamagishi M, Kawashiri MA
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 7 Pages: 634-642
  • DOI: 10.5551/jat.42705
  • NAID: 130007386952
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Guidance for Pediatric Familial Hypercholesterolemia 2017 (2018)
  • Author(s): Harada-Shiba Mariko、Ohta Takao、Ohtake Akira、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Yamashita Shizuya、Yokote Koutaro、Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 6 Pages: 539-553
  • DOI: 10.5551/jat.CR002
  • NAID: 130007382567
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease (2018)
  • Author(s): Tada Hayato、Kawashiri Masa-aki、Nomura Akihiro、Teramoto Ryota、Hosomichi Kazuyoshi、Nohara Atsushi、Inazu Akihiro、Mabuchi Hiroshi、Tajima Atsushi、Yamagishi Masakazu
  • Journal Title: Journal of Clinical Lipidology Volume: 12 Issue: 6 Pages: 1436-1444
  • DOI: 10.1016/j.jacl.2018.08.006
  • Peer Reviewed
• [Journal Article] Remnant-like particles and coronary artery disease in familial hypercholesterolemia (2018)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Sakata K, Inazu A, Mabuchi H, Yamagishi M, Hayashi K
  • Journal Title: Clin Chim Acta Volume: 印刷中 Pages: 120-123
  • DOI: 10.1016/j.cca.2018.04.007
  • Peer Reviewed
• [Journal Article] Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation ― The Hokuriku-Plus AF Registry ― (2018)
  • Author(s): Hayashi Kenshi、Tsuda Toyonobu、Nomura Akihiro、Fujino Noboru、Nohara Atsushi、Sakata Kenji、Konno Tetsuo、Nakanishi Chiaki、Tada Hayato、Nagata Yoji、Teramoto Ryota、Tanaka Yoshihiro、Kawashiri Masa-aki、Yamagishi Masakazu、on behalf of the Hokuriku-Plus AF Registry Investigators
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1271-1278
  • DOI: 10.1253/circj.CJ-17-1085
  • NAID: 130006725972
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant. (2018)
  • Author(s): Liu J, Yagi K, Nohara A, Chujo D, Ohbatake A, Fujimoto A, Miyamoto Y, Kobayashi J, Yamagishi M.
  • Journal Title: J Clin Lipidol Volume: 12 Issue: 2 Pages: 331-337
  • DOI: 10.1016/j.jacl.2017.12.011
  • Peer Reviewed / Open Access
• [Journal Article] sLR11 as a novel predictor of vascular calcification. (2017)
  • Author(s): Nohara A.
  • Journal Title: Atherosclerosis Volume: 265 Pages: 242-243
  • DOI: 10.1016/j.atherosclerosis.2017.07.025
• [Journal Article] Assessments of Carotid Artery Plaque Burden in Patients With Familial Hypercholesterolemia. (2017)
  • Author(s): Tada H, Kawashiri MA, Okada H, Nakahashi T, Sakata K, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Am J Cardiol. Volume: 120 Issue: 11 Pages: 1955-1960
  • DOI: 10.1016/j.amjcard.2017.08.012
  • Peer Reviewed
• [Journal Article] Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia. (2017)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Inazu A, Mabuchi H, Yamagishi M.
  • Journal Title: Eur Heart J. Volume: - Issue: 20 Pages: 1573-1579
  • DOI: 10.1093/eurheartj/ehx004
  • Peer Reviewed / Open Access
• [Presentation] History and Changes of Japanese FH guidelines (2022)
  • Author(s): Atsushi Nohara
  • Organizer: 1st JAS-KSoLA Joint Symposium on FH and Severe Dyslipidemia
  • Int'l Joint Research / Invited
• [Presentation] シンポジウム8：成人FHの診断基準、診療指針はどう変更されたか？ (2022)
  • Author(s): 野原 淳
  • Organizer: 第54回 日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] SYMPOSIUM 18：PCSK9 Inhibitors: Management of High-Risk for Cardiovascular Disease (2021)
  • Author(s): Nohara A.
  • Organizer: The 19th International Symposium on Atherosclerosis
  • Int'l Joint Research
• [Presentation] 第26回診断技術向上セミナー：家族性高コレステロール血症におけるアキレス腱計測の意義 (2021)
  • Author(s): 野原 淳
  • Organizer: 第53回 日本動脈硬化学会総会・学術集会
• [Presentation] FHと遺伝子変異―遺伝子変異と治療の選択― (2020)
  • Author(s): 野原 淳
  • Organizer: 第41回日本アフェレシス学会学術大会
• [Presentation] SYMPOSIUM: Effect of PCSK9i on Lp(a) (2019)
  • Author(s): Atsushi NOHARA
  • Organizer: The 12th ISFA2019 & The 40th JSFA2019
  • Int'l Joint Research / Invited
• [Presentation] 診断技術向上セミナー “Why” and “How” We Should Diagnose Familial Hypercholesterolemia with Standard Evaluation Method for Achilles Tendon Thickness (2019)
  • Author(s): Atsushi NOHARA
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] Lysosomal Acid Lipase Activities Negatively Correlated with Cholesterol-esterification Rates in Statin Users, and were Lower with Common Functional Variant LIPA T16P Carriers in Heterozygous FH (2019)
  • Author(s): Atsushi Nohara, Masa-aki Kawashiri, Yoshikatsu Eto, Hayato Tada, Mika Mori, Chiaki Nakanishi, Akihiro Inazu, Hiroshi Mabuchi
  • Organizer: 2019 ASBMB Deuel Conference on Lipids
  • Int'l Joint Research
• [Presentation] CLINICAL IMPLICATION OF FH GENE TEST: DETECTION RATES IN LDLR AND PCSK9 GENES IN JAPAN (2018)
  • Author(s): Atsushi Nohara, Masa-aki Kawashiri, Hayato Tada, Mika Mori, Chiaki Nakanishi, Akihiro Inazu, Hiroshi Mabuchi
  • Organizer: 86th EAS Congress
  • Int'l Joint Research
• [Presentation] 家族性高コレステロール血症の最新の診断と治療～FH遺伝子診断の有用性～ (2018)
  • Author(s): 野原 淳
  • Organizer: 第25回日本遺伝子診療学会
  • Invited
• [Presentation] シンポジウム2「脂質領域・動脈硬化領域におけるLDLアフェレシス治療の役割」 (2018)
  • Author(s): 野原 淳
  • Organizer: 第39回日本アフェレシス学会学術大会
  • Invited
• [Presentation] シンポジウム4：家族性高コレステロール血症の診断と治療 -ガイドラインを踏まえて- (2018)
  • Author(s): 野原 淳
  • Organizer: 第37回日本脳神経超音波学会
  • Invited
• [Presentation] 日本動脈硬化学会 合同セッション PSCK9阻害剤の臨床「家族性高コレステロール血症」 (2018)
  • Author(s): 野原 淳
  • Organizer: 第27回日本心血管インターベンション治療学会学術集会
  • Invited
• [Presentation] シンポジウム：FH awareness 「FHにおいて遺伝子診断をどのように役立てるか」 (2018)
  • Author(s): 野原 淳
  • Organizer: 第50回 日本動脈硬化学会総会
  • Invited
• [Presentation] COMMON FUNCTIONAL VARIANT LIPA T16P AFFECTS HDL COMPOSITION AMONG PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (2017)
  • Author(s): Atsushi Nohara, Masa-aki Kawashiri, Yoshikatsu Eto, Miwa Fujisaki, Hayato Tada, Mie Yoshida, Mika Mori, Chiaki Nakanishi, Kunimasa Yagi, Akihiro Inazu, Masakazu Yamagishi, Hiroshi Mabuchi
  • Organizer: European Atherosclerosis Society
  • Int'l Joint Research