Role of integrated stress response in adipocyte
| Project/Area Number |
17K09862
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIYAKE Masato 徳島大学, 先端酵素学研究所(プロテオ), 講師 (30588976)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肥満 / 糖尿病 / 臓器連関 / 摂食調節 / ストレス応答 / 摂食 / 脂肪細胞 / 内分泌 / 脂肪 / 統合的ストレス応答 / 小胞体ストレス / 代謝 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of integrated stress response (ISR), which is one of stress response signaling and activated in metabolic disorders, in adipocytes of mice. The ISR did not affect metabolic function in adipocyte. However, activation of the ISR induced GDF15 expression that is known to repress appetite in adipocyte. The ISR-induced GDF15 repressed high-fat diet specific food intake and improved diet-induced obesity.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果によって統合的ストレス応答の活性化は、細胞自律的なストレスへの対応の役割だけでなく、内分泌ホルモンなどを介した臓器連関によって個体レベルでストレスに応答して恒常性を保つために機能していることが示唆された。また、脂肪細胞への適切な統合的ストレス応答の活性化は、摂食行動を制御する可能性が示され新たな肥満や糖尿病の治療標的となることがわかった。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.2020
Author(s)
Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H.
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Journal Title
Life science alliance
Volume: 3
Issue: 3
Pages: 201900576-201900576
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice2017
Author(s)
Kurahashi K, Inoue S, Yoshida S, Ikeda Y, Morimoto K, Uemoto R, Ishikawa K, Kondo T, Yuasa T, Endo I, Miyake M, Oyadomari S, Matsumoto T, Abe M, Sakaue H, Aihara KI.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 24
Issue: 12
Pages: 1215-1230
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Open Access
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