The mechanism of anti-obesity hormone FGF21 via central nervous system
| Project/Area Number |
17K09884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kochi University |
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Principal Investigator |
Nishiyama Mitsuru 高知大学, 教育研究部医療学系臨床医学部門, 教授 (50315008)
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| Co-Investigator(Kenkyū-buntansha) |
津田 雅之 高知大学, 教育研究部医療学系基礎医学部門, 教授 (90406182)
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|---|
| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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|---|
| Keywords | 肥満 / 食欲調節 / 視床下部 / FGF21 / CRH / 視床下部-下垂体-副腎系 |
|---|
| Outline of Final Research Achievements |
The increase in obesity is a social problem and the development of new therapeutic agents is desired. Fibroblast growth factor 21 (FGF21) has anti-obesity effects and may mediate the hypothalamic neuropeptide corticotropin-releasing hormone (CRH). This study investigated the mechanism of FGF21 action. Although the present study did not demonstrate the direct involvement of CRH in the FGF21 mechanism of action, several interesting hypothalamic gene (Acbd4, Glud1) alterations were observed. Further studies are needed to elucidate the full picture of FGF21 central nervous system actions.
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| Academic Significance and Societal Importance of the Research Achievements |
食欲調節に関わる中枢神経回路は複雑であり、種々の研究アプローチにより少しずつ解明していく必要がある。FGF21による抗肥満作用の発現についても、視床下部における様々な神経ペプチドや神経伝達物質が関与することが想定され、今回示された視床下部遺伝子の変化は全体のごく一部と考えられる。本研究成果をさらに発展させることにより、FGF21中枢神経作用の解明、および、有用な肥満治療薬の開発につなげていきたいと考えている。
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Report
(7 results)
Research Products
(55 results)
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[Journal Article] Efficacy and safety of once monthly pasireotide in Cushing’s disease: a 12 month clinical trial2018
Author(s)
Lacroix A, Gu F, Gallardo W, Pivolello R, Yu Y, Witek P, Boscaro M, Salvatori R, Yamada M, Tauchmanova L, Roughton M, Ravichandrean S, Petersenn S, Biller BMK, Newell-Price J, Pasireotide G2304 Study Group (Nishiyama M, et al.)
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Journal Title
Lancet Diabetes Endocrinol
Volume: 6
Issue: 1
Pages: 17-26
DOI
Related Report
Peer Reviewed
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[Book] 臨床検査ガイド2020
Author(s)
西山 充、他多数
Total Pages
1099
Publisher
文光堂
ISBN
9784830680373
Related Report
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[Book] 新しい薬理学2018
Author(s)
西山 充、他多数
Total Pages
573
Publisher
西村書店
ISBN
9784890134854
Related Report
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