• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of regulatory mechanism for RANKL-dependent osteo-network by transcriptional factor complex analysis

Research Project

Project/Area Number 17K09892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionToho University

Principal Investigator

Tatsuno Ichiro  東邦大学, 医学部, 教授 (80282490)

Co-Investigator(Kenkyū-buntansha) 小出 尚史  千葉大学, 医学部附属病院, 助教 (30507223)
鈴木 佐和子  千葉大学, 医学部附属病院, 助教 (60400892)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨リモデリング / 破骨 / 分化 / 遺伝子 / ゲノム / 発現制御 / エピゲノム / 転写因子 / 破骨細胞機能 / エピジェネティクス / シグナル伝達 / 転写
Outline of Final Research Achievements

Nuclear factor of activated T-cell cytoplasmic 1 (NFATc1) is a master regulator of osteoclast differentiation induced by RANKL, which is a pivotal cytokine for osteoclast differentiation. We identified novel epigenetic/chromatin regulatory molecules and wolf-Hirschhorn syndrome candidate 1 (WHSC1) as NFATc1 interaction proteins using tandem affinity purification followed by LC-MS / MS analysis. WHSC1 is a histone H3-K36 methyltransferase, and its mutations in human is known to cause abnormal cartilage and bone. Then we created WHSC1 and RANKL knockout cells by CRISPR / Cas9 system. And revealed that both of knockout cells showed decreasing osteoclast differentiation-related genes after RANKL stimulation. Further, WHSC1 and RANKL mutually suppressed transcription. This study clarified one of the regulatory systems of complex differentiation process in osteoclasts, which mediated by WHSC1 in the RANKL-NFATc1 complexes in response to various upstream signals.

Academic Significance and Societal Importance of the Research Achievements

骨粗鬆症治療において様々な治療薬の選択が可能となってきたが、骨吸収抑制を主体とした薬剤は、特に骨形成まで抑制してしまう問題もあり、破骨細胞による骨芽細胞機能維持機能を保持しながら過剰な骨吸収を抑制することのできる薬剤開発が望まれる。本研究でRANKL 依存的骨ネットワーク制御における特定のシグナルをモジュレートする新たな制御機構を解明することが出来た。更に破骨細胞内で発現時期や機能の異なる遺伝子の発現調節を行うメカニズムとしてNFATc1を中心とするepigenetic mechanisms を明らかとし骨エピジェネティクス制御の解明に役立つと共に、創薬基盤の開発に繋がることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (63 results)

All 2020 2019 2018 2017

All Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 21 results) Presentation (38 results) (of which Int'l Joint Research: 7 results,  Invited: 6 results) Book (3 results)

  • [Journal Article] Prevention of Cardiovascular Events with Omega-3 Polyunsaturated Fatty Acids and the Mechanism Involved2020

    • Author(s)
      Watanabe Yasuhiro、Tatsuno Ichiro
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 27 Issue: 3 Pages: 183-198

    • DOI

      10.5551/jat.50658

    • NAID

      130007804187

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2020-03-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fracture risk assessment tool may not indicate bone fragility in women with type 2 diabetes.2020

    • Author(s)
      Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
    • Journal Title

      Am J Med Sci.

      Volume: S0002-9629 Issue: 5 Pages: 30119-1

    • DOI

      10.1016/j.amjms.2020.04.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcome of pitavastatin versus atorvastatin therapy in patients with hypercholesterolemia at high risk for atherosclerotic cardiovascular disease2020

    • Author(s)
      Moroi Masao、Nagayama Daiji、Hara Fumihiko、Saiki Atsuhito、Shimizu Kazuhiro、Takahashi Mao、Sato Naoko、Shiba Teruo、Sugimoto Hideki、Fujioka Toshiki、Chiba Tatsuo、Nishizawa Kosuke、Usui Shuki、Iwasaki Yasuo、Tatsuno Ichiro、Sugi Kaoru、Yamasaki Junichi、Yamamura Shigeo、Shirai Kohji
    • Journal Title

      International Journal of Cardiology

      Volume: 305 Pages: 139-146

    • DOI

      10.1016/j.ijcard.2020.01.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bezafibrate Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Hypertriglyceridemic Patients with Type 2 Diabetes Mellitus2019

    • Author(s)
      Yamaguchi T, Shirai K, Nagayama D, Nakamura S, Oka R, Tanaka S, Watanabe Y, Imamura H, Sato Y, Kawana H, Ohira M, Saiki A, Shimizu N, Tatsuno I.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 26 Issue: 7 Pages: 659-669

    • DOI

      10.5551/jat.45799

    • NAID

      130007671311

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2019-07-01
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of Hashimoto’s thyroiditis with multiple drug resistance and high expression of efflux transporters.2019

    • Author(s)
      Yoshida T, Nakayama A, Tamura A, Higuchi S, Sakuma I, Nagano H, Saulo J.A. Felizola, Takemoto M, Tatsuno I, Koide H, Yokote K, Tanaka T.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 105 Issue: 2 Pages: 399-406

    • DOI

      10.1210/clinem/dgz073

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic Sleeve Gastrectomy Significantly Increases Serum Lipoprotein Lipase Level in Obese Patients2019

    • Author(s)
      Ohira Masahiro、Yamaguchi Takashi、Saiki Atsuhito、Nakamura Shoko、Tanaka Shou、Oka Rena、Watanabe Yasuhiro、Sato Yuta、Oshiro Takashi、Murano Takeyoshi、Tatsuno Ichiro
    • Journal Title

      Obesity Facts

      Volume: 12 Issue: 3 Pages: 357-368

    • DOI

      10.1159/000500360

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum oxidative stress in patients with pulmonary Mycobacterium avium complex disease2019

    • Author(s)
      Wakabayashi Hiroki、Matsuzawa Yasuo、Hayakawa Sho、Irie Tamako、Rikitake Hagino、Tatsuno Ichiro
    • Journal Title

      Heliyon

      Volume: 5 Issue: 11 Pages: e02775-e02775

    • DOI

      10.1016/j.heliyon.2019.e02775

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Marker Of Sepsis Severity Is Associated With The Variation In Cardio-Ankle Vascular Index (CAVI) During Sepsis Treatment2019

    • Author(s)
      Nagayama Daiji、Imamura Haruki、Endo Kei、Saiki Atsuhito、Sato Yuta、Yamaguchi Takashi、Watanabe Yasuhiro、Ohira Masahiro、Shirai Kohji、Tatsuno Ichiro
    • Journal Title

      Vascular Health and Risk Management

      Volume: Volume 15 Pages: 509-516

    • DOI

      10.2147/vhrm.s228506

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Background characteristics and postoperative outcomes of insufficient weight loss after laparoscopic sleeve gastrectomy in Japanese patients.2019

    • Author(s)
      Saiki A, Yamaguchi T, Tanaka S, Sasaki A, Naitoh T, Seto Y, Matsubara H, Yokote K, Okazumi S, Ugi S, Yamamoto H, Ohta M, Ishigaki Y, et al
    • Journal Title

      Ann Gastroenterol Surg.

      Volume: 3 Issue: 6 Pages: 638-647

    • DOI

      10.1002/ags3.12285

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells2019

    • Author(s)
      26.Tanaka S, Ishihara N, Suzuki S, Watanabe Y, Nagayama D, Yamaguchi T, Ohira M, Saiki A, Tanaka T, Tatsuno I.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 10009-10009

    • DOI

      10.1038/s41598-019-46461-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in positive relation between cardio-ankle vascular index (CAVI) and each of four blood pressure indices in real-world Japanese population.2019

    • Author(s)
      Nagayama D, Watanabe Y, Saiki A, Shirai K, Tatsuno I.
    • Journal Title

      J Hum Hypertens.

      Volume: 33 Issue: 3 Pages: 210-217

    • DOI

      10.1038/s41371-019-0167-1

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study Protocol for the Effects of Formula Diet with Dapagliflozin on Metabolic Improvement and Body Composition in Type 2 Diabetes Mellitus.2019

    • Author(s)
      Watanabe Y, Kuribayashi N, Uchida D, Suzuki D, Kato M, Nagayama D, Ohashi H, Ohira M, Saiki A, Tatsuno I.
    • Journal Title

      Diabetes Ther.

      Volume: 10 Issue: 1 Pages: 311-321

    • DOI

      10.1007/s13300-018-0555-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Relationship between Bladder, Periarterial and Somatic Neuropathy in Diabetes2018

    • Author(s)
      Sakakibara R, Takahashi O, Nishimura H, Tateno F, Kishi M, Tsuyusaki Y, Aiba Y, Tatsuno I
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 15 Pages: 2165-2168

    • DOI

      10.2169/internalmedicine.9749-17

    • NAID

      130007428858

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-08-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipid Parameters are Independently Associated with Cardio–Ankle Vascular Index (CAVI) in Healthy Japanese Subjects2018

    • Author(s)
      Nagayama D, Watanabe Y, Saiki A, Shirai K, Tatsuno I
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 25 Issue: 7 Pages: 621-633

    • DOI

      10.5551/jat.42291

    • NAID

      130007386956

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2018-07-01
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy.2018

    • Author(s)
      Watanabe Y, Yamaguchi T, Ishihara N, Nakamura S, Tanaka S, Oka R, Imamura H, Sato Y, Ban N, Kawana H, Ohira M, Shimizu N, Saiki A, Tatsuno I.
    • Journal Title

      Prostaglandins Other Lipid Mediat.

      Volume: 134 Pages: 16-23

    • DOI

      10.1016/j.prostaglandins.2017.11.002

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful Treatment of Rapidly Progressive Life-Threatening Esophageal Submucosal Hematoma in a Patient With van der Hoeve Syndrome.2018

    • Author(s)
      Watanabe Y, Shimizu N, Iwakawa M, Yamaguchi T, Ban N, Kawana H, Saiki A, Sakaida E, Nakaseko C, Matsuura Y, Aotsuka N, Bujo H, Tatsuno I
    • Journal Title

      J Clin Med Res.

      Volume: 10 Issue: 2 Pages: 154-157

    • DOI

      10.14740/jocmr3270w

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey2018

    • Author(s)
      Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
    • Journal Title

      Endocrine Journal

      Volume: 65 Issue: 2 Pages: 193-202

    • DOI

      10.1507/endocrj.EJ17-0331

    • NAID

      130006402991

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.2018

    • Author(s)
      Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 115 Issue: 33 Pages: 8370-8375

    • DOI

      10.1073/pnas.1804243115

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of 7-ketocholesterol on Hyaluronic Acid Synthase 2 in Human Aortic Smooth Muscle Cells.2018

    • Author(s)
      Nagumo-Yoshikawa A, Ishihara N, Watanabe F, Shirai K, Tatsuno I.
    • Journal Title

      Toho Journal of Medicine.

      Volume: 4 Pages: 74-80

    • NAID

      120006523345

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells.2017

    • Author(s)
      Ishihara N, Suzuki S, Tanaka S, Watanabe Y, Nagayama D, Saiki A, Tanaka T, Tatsuno I.
    • Journal Title

      Mol Med Rep.

      Volume: 16 Issue: 4 Pages: 4756-4762

    • DOI

      10.3892/mmr.2017.7141

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes2017

    • Author(s)
      Imamura H, Nagayama D, Ishihara N, Tanaka S, Watanabe R, Watanabe Y, Sato Y, Yamaguchi T, Ban N, Kawana H, Ohira M, Endo K, Saiki A, Shirai K, Tatsuno I
    • Journal Title

      Molecular Genetics and Metabolism Reports

      Volume: 12 Pages: 44-50

    • DOI

      10.1016/j.ymgmr.2017.05.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effect of Nitroglycerin on Arterial Stiffness of the Aorta and the Femoral-Tibial Arteries2017

    • Author(s)
      Yamamoto T, Shimizu K, Takahashi M, Tatsuno I, Shirai K.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 10 Pages: 1048-1057

    • DOI

      10.5551/jat.38646

    • NAID

      130006110243

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Bariatric Surgery Significantly Increases Serum Lipoprotein Lipase Level in Patients with Obesity.2019

    • Author(s)
      Ohira M, Yamaguchi Y, Saiki A, Nakamura S, Tanaka S, Watanabe Y, Kawagoe N, Oshiro T, Murano T, Oka R, Tatsuno I
    • Organizer
      Obesity Week
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of formula diet with dapagliflozin on metabolic improvement and body composition in type 2 diabetes (Diet-Dapper Study).2019

    • Author(s)
      Watanabe Y, Kuribayashi N, Uchida D, Suzuki D, Kato M, Nagayama D, Ohashi H, Nakamura S, Tanaka S, Oka R, Yamaguchi T, Ohira M, Shimizu N, Saiki A, Tatsuno I.
    • Organizer
      55th ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本国内における減量(代謝・糖尿病)手術の現状と課題‐代謝手術にかかわる多職種医療チーム育成の必要性2019

    • Author(s)
      龍野一郎
    • Organizer
      第32回日本内視鏡外科学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 肥満症への集学的治療‐内科治療と減量(代謝)手術2019

    • Author(s)
      龍野一郎
    • Organizer
      日本内分泌学会第6回生涯教育講習会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 女性膠原病患者におけるステロイド骨粗鬆症性臨床椎体骨折と生命予後‐千葉下志津リウマチコホート研究‐2019

    • Author(s)
      龍野一郎†, 中村祥子†, 渡邊康弘†, 佐藤悠太†, 大平征宏†, 杉山隆夫
    • Organizer
      第12回日本性差医学・医療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ERBB3 germline mutationを認め多臓器悪性腫瘍を合併した両側副腎および膀胱褐色細胞腫/パラガンクリオーマ(PPC/PGL)の一例2018

    • Author(s)
      石田晶子、中山哲俊、樋口誠一郎、永野秀和、小出尚史、龍野一郎、田中知明、横手幸太郎
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 骨代謝制御機構におけるAKAP13 の機能的役割2018

    • Author(s)
      石田晶子、中山哲俊、小出尚史、龍野一郎、田中知明、横手幸太郎
    • Organizer
      第36回日本骨代謝学会学術集会、
    • Related Report
      2018 Research-status Report
  • [Presentation] Xanthine oxidoreductase活性及びその血管弾性能Cardio-Ankle Vascular Index (CAVI)に及ぼす影響-2型糖尿病患者での検討-2018

    • Author(s)
      大平征宏、中村祥子、岡怜奈、田中翔、渡邊康弘、佐藤悠太、今村榛樹、山口崇、川名秀俊、齋木厚人、清水直美、石原典子、龍野一郎
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 自然からの贈り物オメガ3系多価不飽和脂肪酸による生活習慣病予防とその作用機構2018

    • Author(s)
      龍野一郎
    • Organizer
      日本脂質栄養学会第27回大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 体重管理に難渋するPickwick症候群を合併したPrader Willi症候群の一例2018

    • Author(s)
      佐藤悠太†, 中村祥子†, 田中翔†, 岡怜奈†, 渡邊康弘†, 山口崇†, 大平征宏†, 齋木厚人†, 龍野一郎†
    • Organizer
      第19回日本内分泌学会関東甲信越支部学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高度肥満の持つ複雑な病態‐個別化・統合された肥満症治療を目指して‐2018

    • Author(s)
      龍野一郎
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 食欲中枢異常による難治性高度肥満症の実態調査のための研究班(龍野班)の調査研究2018

    • Author(s)
      龍野一郎†, 齋木厚人†, 小野崎彰, 松原久裕, 岡住慎一†, 瀬戸泰之, 佐々木章, 内藤剛, 太田正之, 山本寛, 関洋介, 清水英治, 横手幸太郎, 石垣泰, 卯木智, 正木孝幸, 入江潤一郎, 白井厚治
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高度肥満に合併する非虚血性心筋症の心形態および機能性特徴と、減量による影響2018

    • Author(s)
      山口崇†, 戸谷俊介†, 中村祥子†, 岡怜奈†, 田中翔†, 渡邊康弘†, 大平征宏†, 清水直美†, 大城崇司†, 齋木厚人†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] スリーブ状胃切除術前後にフォーミュラ食を用いた腎不全合併高度肥満症の一例2018

    • Author(s)
      渡邊康弘†, 瀬尾恵理†, 金居理恵子†, 山口崇†, 齋木厚人†, 林果林†, 大城崇司†, 鮫田真理子†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] スリーブ状胃切除術を施行した日本人における術前BMI別の肥満関連疾患とその経過および心理社会的背景の実態調査(多施設研究J-SMART)2018

    • Author(s)
      齋木厚人†, 山口崇†, 佐々木章, 内藤剛, 松原久裕, 卯木智, 山本寛, 太田正之, 笠間和典, 関洋介, 辻野元祥, 清水英治, 宮崎安弘, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高度肥満症患者におけるビタミンの実態と、肥満外科治療の影響について2018

    • Author(s)
      林田美帆†, 山口崇†, 川久保さおり†, 山浦一恵†, 瀬尾恵理†, 金居理恵子†, 鮫田真理子†, 辻沙耶佳†, 大城崇司†, 齋木厚人†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高度肥満症患者における性格特性、知的能力および精神疾患の特徴と、それらが内科・外科的減量治療に及ぼす影響2018

    • Author(s)
      山口崇†, 中村祥子†, 岡怜奈†, 田中翔†, 渡邊康弘†, 佐藤悠太†, 今村榛樹†, 川名秀俊†, 大平征宏†, 齋木厚人†, 大城崇司†, 林果林†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 褥瘡、間接拘縮、筋萎縮、腎障害、心不全を合併した高度肥満症に対し、フォーミュラ食を用いたNST管理と理学療法が奏功した一例2018

    • Author(s)
      山浦一恵†, 渡邊康弘†, 川久保さおり†, 林田美帆†, 瀬尾恵理†,金居理恵子†, 鮫田真理子†, 縄田千恵†, 秋葉崇†, 戸田祐子†, 清藤友里絵†, 佐藤悠太†, 川名秀俊†, 齋木厚人†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高度肥満患者の体組成が血管弾性におよぼす影響2018

    • Author(s)
      山口崇†, 中村祥子†, 岡怜奈†, 田中翔†, 渡邊康弘†, 今村榛樹†, 佐藤悠太†, 川名秀俊†, 大平征宏†, 清水直美†, 齋木厚人†, 白井厚治†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高度肥満患者の心機能および形態と血管弾性との関連2018

    • Author(s)
      山口崇†, 中村祥子†, 岡怜奈†, 田中翔†, 渡邊康弘†, 今村榛樹†, 佐藤悠太†, 川名秀俊†, 大平征宏†, 清水直美†, 齋木厚人†, 白井厚治†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肥満外科手術後のリバウンド患者に対して薬物療法の追加が奏功した症例2018

    • Author(s)
      原敬一†, 武田有希†, 府川和樹†, 増田雅行†, 真坂亙†, 今村榛樹†, 齋木厚人†, 大城崇司†, 林果林†, 龍野一郎†
    • Organizer
      第36回日本肥満症治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肥満症に対する効果的な治療戦略と健康障害の改善に有効な減量数値目標を見出すための研究2018

    • Author(s)
      横尾英孝、越坂理也、武田健治、前田祐香里、石川耕、小野啓、横手幸太郎、佐藤泰憲、浅原哲子、下村伊一郎、龍野一郎、津下一代、山内敏正、門脇孝
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腹腔鏡下スリーブ状胃切除術を施行した日本人における術前BMI別の肥満関連疾患とその経過および心理社会的背景の実態調査(多施設研究J-SMART)2018

    • Author(s)
      齋木厚人, 山口崇, 佐々木章, 内藤剛, 松原久裕, 卯木智, 山本寛, 太田正之, 笠間和典, 関洋介, 辻野元祥, 清水英治, 宮崎安弘, 龍野一郎
    • Organizer
      第50回日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 魚油(オメガ3系多価不飽和脂肪酸)による生活習慣病予防とその作用機構2018

    • Author(s)
      龍野一郎
    • Organizer
      第32回日本臨床内科医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] グルカゴノーマに併発した糖尿病に対しメトホルミンが有用であった一例2018

    • Author(s)
      渡邊康弘†, 中村祥子†, 田中翔†, 岡怜奈†, 河越尚幸†, 佐藤悠太†, 山口崇†, 大平征宏†, 清水直美†, 齋木厚人†, 龍野一郎†
    • Organizer
      第46回内分泌代謝研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肥満外科術後患者に対するビタミンD補充強化の検討2018

    • Author(s)
      中村祥子†, 山口崇†, 鮫田真理子†, 田中翔†, 河越尚幸†, 渡邊康弘†, 佐藤悠太†, 大平征宏†, 大城崇司†, 齋木厚人†, 龍野一郎†
    • Organizer
      第28回臨床内分泌代謝Update
    • Related Report
      2018 Research-status Report
  • [Presentation] 高度肥満患者の心筋障害における血管弾性の影響とその規定因子2018

    • Author(s)
      田中翔†, 山口崇†, 中村祥子†, 岡怜奈†, 河越尚幸†, 渡邊康弘†, 佐藤悠太†, 大平征宏†, 清水直美†, 齋木厚人†, 白井厚治†, 龍野一郎†
    • Organizer
      第28回臨床内分泌代謝Update
    • Related Report
      2018 Research-status Report
  • [Presentation] 糖尿病を併発したグルカゴノーマに対するメトホルミンの有用性2018

    • Author(s)
      渡邊康弘†, 山口崇†, 中村祥子†, 田中翔†, 岡怜奈†, 河越尚幸†, 佐藤悠太†, 大平征宏†, 清水直美†, 齋木厚人†, 龍野一郎†
    • Organizer
      第28回臨床内分泌代謝Update
    • Related Report
      2018 Research-status Report
  • [Presentation] The effects of formula diet on body fat and skeletal muscle after bariatric surgery in severe obese patients2018

    • Author(s)
      Kanai R, Saiki A, Kawakubo S, Hayashida M, Yamaura K, Seo E, Sameda M, Tsuji S, Akiba T, Terayama K, Ogawa A, Ohshiro T, Okazumi S, Shirai K, Tatsuno I
    • Organizer
      Asia Pacific Metabolic and Bariatric Surgery Society 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of Body Weight and Metabolic Improvements Between Surgical and Non-Surgical Treatment in Morbid Obese Patients2018

    • Author(s)
      Watanabe Y, Yamaguchi T, Saiki A, Nakamura S, Oka R, Tanaka S, Imamura H, Sato Y, Kawana H, Ohira M, Oshiro T, Tatsuno I
    • Organizer
      Asia Pacific Metabolic and Bariatric Surgery Society 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Physiological and Psychological Features of Non-responders for Bariatric Surgery in Japanese Patients with Morbid Obesity2018

    • Author(s)
      Yamaguchi T, Nakamura S, Tanaka S, Watanabe Y, Imamura H, Sato Y, Kawana H, Ohira M, Tsuji S, Nabekura T, Oshiro T, Hayashi K, Saiki A, Tatsuno I
    • Organizer
      Asia Pacific Metabolic and Bariatric Surgery Society 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] オキシステロールによるヒトメサンギウム細胞障害時の細胞内ROSを介するアラキドン酸カスケードの制御2017

    • Author(s)
      渡邉康弘, 龍野一郎
    • Organizer
      第150回東邦医学会例会
    • Related Report
      2017 Research-status Report
  • [Presentation] The Fracture Risk Assessment Tool(FRAX) without femoral neck bone mineral density (BMD) could not diagnose osteoporosis in Japanese women including premenopausals.2017

    • Author(s)
      岡怜奈, 龍野一郎
    • Organizer
      第150回東邦医学会例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 一般日本人女性におけるFRAXの特徴と有用性2017

    • Author(s)
      岡怜奈, 大平征宏, 田中翔, 渡邉康弘, 佐藤悠太, 今村榛樹, 山口崇, 川名秀俊, 齋木厚人, 龍野一郎
    • Organizer
      第19回日本骨粗鬆症学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肥満外科治療から見た肥満・代謝障害への消化管制御の意義2017

    • Author(s)
      龍野一郎
    • Organizer
      第38回日本肥満学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] AtorvastatinによるFads1, Fads2, Elovl5遺伝子発現の増強とその作用機構2017

    • Author(s)
      龍野一郎, 石原典子, 田中翔, 渡邉康弘, 大平征宏, 齋木厚人, 清水直美
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 7-ketocholesterol regulates inflammation in mesangial cells: potential role in diabetic nephropathy.2017

    • Author(s)
      Watanabe Y, Yamaguchi T, Ishihara N, Tanaka S, Oka R, Rikitake A, Imamura H, Sato Y, Ban N, Kawana H, Ohira M, Simizu N, Saiki A, Tatsuno I
    • Organizer
      EASD2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Atorvastatin increases FADS1, FADS2, and ELOVL5 gene expression via GGPP-dependent RHO kinase pathway in 3T3-L1 cells.2017

    • Author(s)
      Tatsuno I, Tanaka S, Watanabe Y, Ishihara N, Suzuki S, Tanaka T
    • Organizer
      EASD2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 「高度肥満と糖尿病」 ここが知りたい!糖尿病診療ハンドブックVer.42019

    • Author(s)
      木厚人, 龍野一郎
    • Total Pages
      8
    • Publisher
      中外医学社
    • Related Report
      2019 Annual Research Report
  • [Book] 「尿酸とCAVI」CAVIから眺める血管機能学2019

    • Author(s)
      龍野一郎
    • Total Pages
      3
    • Publisher
      特定非営利活動法人血管健康増進協会
    • Related Report
      2019 Annual Research Report
  • [Book] 「血管機能改善作用を持つサプリメントとCAVI」CAVIから眺める血管機能学2019

    • Author(s)
      今村榛樹, 龍野一郎
    • Total Pages
      3
    • Publisher
      特定非営利活動法人 血管健康増進協会
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi