Analysis of neural cell marker-expressing hematopoietic supporting cells in human bone marrow failure

• Project/Area Number: 17K09898
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: University of Tsukuba
• Principal Investigator: Obara Naoshi 筑波大学, 医学医療系, 准教授 (70422178)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 造血不全 / Nestin / 造血支持細胞 / GFAP / 骨髄異形成症候群 / 赤芽球島 / 造血微小環境 / 炎症性貧血 / IL-6 / マクロファージ / Notchシグナル / Rbpj / 分化障害 / 赤芽球

Outline of Final Research Achievements

Various types of hematopoietic supporting cells have been reported. Recently, Nestin-expressing cells, which are neural stem-cell markers, and Schwann cells were identified in the bone marrow.
We analyzed Nestin-expressing stromal cells (NESCs) and glial fibrillary acidic protein (GFAP)-expressing cells, which are Schwann cell markers, in myelodysplastic syndrome (MDS). We found a marked increase in the NESC levels in MDS with fibrosis (MDS-F) at a high frequency (9/19; 47.4%), but not in MDS without fibrosis (0/26; 0%). In eight of the nine (88.9%) MDS-F cases with elevated NESCs, a majority of NESCs also expressed GFAP, with an additional increase in GFAP single-positive cells. Furthermore, in seven of the nine cases, a prominent structure was observed characterized by neurofilament heavy chain staining surrounded by NESCs with GFAP expression. This structure may represent peripheral nerve axons surrounded by Schwann cells and could be associated with the pathophysiology of MDS-F.

Academic Significance and Societal Importance of the Research Achievements

骨髄異形成症候群（MDS）をはじめとした造血不全は最も治療困難な疾患の一つであり、輸血依存となることも多く、医療のみならず社会的・医療経済上も影響が大きい疾患である。メチル化阻害剤などが試みられているが、いまだ根治的治療については造血幹細胞移植以外ないのが現状であり、高齢者・ドナーのいない患者などでは治療に苦慮することも多い。
今回、我々は繊維化を伴うMDSについて、造血支持細胞の異常が関与していることを示した。また、マウスモデルにおいても造血支持細胞の異常によって赤血球造血が障害されることを示した。今後、新たな予後因子の決定・繊維化をターゲットにした新規治療法の開発などへの展開が期待できる。

Research Products

• [Journal Article] Hematologic recovery induced by eltrombopag in Japanese patients with aplastic anemia refractory or intolerant to immunosuppressive therapy. (2019)
  • Author(s): Yamazaki H, Ohta K, Iida H, Imada K, Obara N, Tokumine Y, Tomiyama Y, Usuki K, Imajo K, Miyamura K, Sasaki O, Fanghong Z, Hattori T, Tajima T, Matsuda A, Nakao S.
  • Journal Title: Int J Hematol Volume: 110 Pages: 187-196
  • DOI: 10.1007/s12185-019-02683-1
  • Peer Reviewed
• [Journal Article] Notch signaling in Nestin-expressing cells in the bone marrow maintains erythropoiesis via macrophage integrity (2019)
  • Author(s): Sakamoto Tatsuhiro、Obara Naoshi、Nishikii Hidekazu、Kato Takayasu、Luan Cao Sy、Fujimura Ryosuke、Yagita Hideo、Sakata-Yanagimoto Mamiko、Takahashi Satoru、Chiba Shigeru
  • Journal Title: Stem cells Volume: 印刷中 Pages: 924-936
  • DOI: 10.1002/stem.3011
  • Peer Reviewed / Open Access
• [Journal Article] Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia (2019)
  • Author(s): Nishikii Hidekazu、Kurita Naoki、Shinagawa Atsushi、Sakamoto Tatsuhiro、Kusakabe Manabu、Yokoyama Yasuhisa、Kato Takayasu、Sakata-Yanagimoto Mamiko、Obara Naoshi、Hasegawa Yuichi、Nakamura Naoya、Chiba Shigeru
  • Journal Title: Case Report in Hematology Volume: 2019 Pages: 1-5
  • DOI: 10.1155/2019/9710790
  • NAID: 120007128070
  • Peer Reviewed / Open Access
• [Journal Article] Prominence of nestin-expressing Schwann cells in bone marrow of patients with myelodysplastic syndromes with severe fibrosis (2019)
  • Author(s): Cao-Sy Luan、Obara Naoshi、Sakamoto Tatsuhiro、Kato Takayasu、Hattori Keiichiro、Sakashita Shingo、Nannya Yasuhito、Ogawa Seishi、Harada Hironori、Sakata-Yanagimoto Mamiko、Nishikii Hidekazu、Chiba Shigeru
  • Journal Title: Int J Hematol Volume: 109 Pages: 309-318
  • DOI: 10.1007/s12185-018-02576-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High efficacy of eculizumab treatment for fulminant hemolytic anemia in primary cold agglutinin disease (2019)
  • Author(s): Makishima Kenichi、Obara Naoshi、Ishitsuka Kantaro、Sukegawa Shinichiro、Suma Sakurako、Kiyoki Yusuke、Baba Naoko、Sakamoto Tatsuhiro、Kato Takayasu、Kusakabe Manabu、Nishikii Hidekazu、Kurita Naoki、Yokoyama Yasuhisa、Sakata-Yanagimoto Mamiko、Hasegawa Yuichi、Chiba Shigeru
  • Journal Title: Ann Hematol Volume: 98 Pages: 1031-1032
  • DOI: 10.1007/s00277-018-3521-4
  • NAID: 120007128039
  • Peer Reviewed
• [Journal Article] Genetic evidence implies that primary and relapsed tumors arise from common precursor cells in primary central nervous system lymphoma (2019)
  • Author(s): Hattori Keiichiro、Sakata-Yanagimoto Mamiko、Kusakabe Manabu、Nanmoku Toru、Suehara Yasuhito、Matsuoka Ryota、Noguchi Masayuki、Yokoyama Yasuhisa、Kato Takayasu、Kurita Naoki、Nishikii Hidekazu、Obara Naoshi、Takano Shingo、Ishikawa Eiichi、Matsumura Akira、Muratani Masafumi、Hasegawa Yuichi、Chiba Shigeru
  • Journal Title: Cancer Sci Volume: 110 Pages: 401-407
  • DOI: 10.1111/cas.13848
  • NAID: 120007128280
  • Peer Reviewed / Open Access
• [Journal Article] Random Skin Biopsies Before Brain Biopsy for Intravascular Large B-Cell Lymphoma (2019)
  • Author(s): Yamada Erika、Ishikawa Eiichi、Watanabe Rei、Matsumura Hideaki、Sakamoto Noriaki、Ishii Akiko、Tamaoka Akira、Hattori Keiichiro、Obara Naoshi、Chiba Shigeru、Nakamagoe Kiyotaka、Matsuda Masahide、Tsurubuchi Takao、Tomidokoro Yasushi、Akutsu Hiroyoshi、Zaboronok Alexander、Shibuya Makoto、Takano Shingo、Matsumura Akira
  • Journal Title: World Neurosurg Volume: 121 Pages: 364-369
  • DOI: 10.1016/j.wneu.2018.09.110
  • Peer Reviewed
• [Journal Article] The prognosis of disseminated intravascular coagulation associated with hematologic malignancy and its response to recombinant human thrombomodulin (2019)
  • Author(s): Kurita Naoki、Sakamoto Tatsuhiro、Kato Takayasu、Kusakabe Manabu、Yokoyama Yasuhisa、Nishikii Hidekazu、Sakata-Yanagimoto Mamiko、Obara Naoshi、Hasegawa Yuichi、Chiba Shigeru
  • Journal Title: Thromb Res Volume: 173 Pages: 57-64
  • DOI: 10.1016/j.thromres.2018.11.014
  • Peer Reviewed
• [Journal Article] Fatal exacerbations of chronic active Epstein-Barr virus infection subsequent to cytotoxic chemotherapy (2019)
  • Author(s): Suma S, Kurita N, Baba N, Ishitsuka K, Sukegawa S, Makishima K, Kiyoki Y, Maruyama Y, Kato T, Yokoyama Y, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S
  • Journal Title: Jpn. J. Clin. Hematol. Volume: 60 Issue: 4 Pages: 286-290
  • DOI: 10.11406/rinketsu.60.286
  • NAID: 130007642867
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Successful management of primary immune thrombocytopenia with romiplostim during open heart surgery in a hemodialysis patient (2019)
  • Author(s): 錦井 秀和、栗田 尚樹、日下部 学、横山 泰久、加藤 貴康、坂田（柳元） 麻実子、小原 直、長谷川 雄一、千葉 滋
  • Journal Title: Jpn. J. Clin. Hematol. Volume: 60 Issue: 1 Pages: 28-28
  • DOI: 10.11406/rinketsu.60.28
  • NAID: 130007590727
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed / Open Access
• [Journal Article] Blastic plasmacytoid dendritic cell neoplasm accompanied by chronic myelomonocytic leukemia successfully treated with azacitidine (2018)
  • Author(s): 助川 慎一郎、横山 泰久、錦井 秀和、加藤 貴康、日下部 学、栗田 尚樹、小原 直、長谷川 雄一、千葉 滋、坂田（柳元） 麻実子、松岡 亮太、百瀬 春佳、清木 祐介、野口 雅之、中村 直哉、渡辺 玲、藤本 学
  • Journal Title: Jpn. J. Clin. Hematol. Volume: 59 Issue: 12 Pages: 2567-2573
  • DOI: 10.11406/rinketsu.59.2567
  • NAID: 130007554669
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature (2018)
  • Author(s): Miki Kosuke、Obara Naoshi、Makishima Kenichi、Sakamoto Tatsuhiro、Kusakabe Manabu、Kato Takayasu、Kurita Naoki、Nishikii Hidekazu、Yokoyama Yasuhisa、Sakata-Yanagimoto Mamiko、Hasegawa Yuichi、Chiba Shigeru
  • Journal Title: Case Reports in Hematology Volume: 2018 Pages: 1-5
  • DOI: 10.1155/2018/7863943
  • NAID: 120007128268
  • Peer Reviewed
• [Journal Article] Reference guide for adult chronic neutropenia (2018)
  • Author(s): 横山 泰久、千葉 滋、日本医療研究開発機構・難治性疾患実用化研究事業「成人慢性好中球減少症の診療ガイドライン作成に向けた予後追跡調査」研究班、高見 昭良、森 康雄、佐藤 信也、鈴木 隆浩、五所 正彦、小原 直、宮﨑 泰司、赤司 浩一
  • Journal Title: Jpn. J. Clin. Hematol. Volume: 59 Issue: 7 Pages: 845-857
  • DOI: 10.11406/rinketsu.59.845
  • NAID: 130007430620
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Establishment of a flow cytometry assay for detecting paroxysmal nocturnal hemoglobinuria-type cells specific to patients with bone marrow failure (2018)
  • Author(s): Hosokawa Kohei、Sugimori Chiharu、Ishiyama Ken、Takamatsu Hiroyuki、Noji Hideyoshi、Shichishima Tsutomu、Obara Naoshi、Chiba Shigeru、Ninomiya Haruhiko、Shirasugi Yukari、Nakamura Yoshihiko、Ando Kiyoshi、Ueda Yasutaka、Yonemura Yuji、Kawaguchi Tatsuya、Nishimura Jun-ichi、Kanakura Yuzuru、Nakao Shinji
  • Journal Title: Annals of hematology Volume: 97 Pages: 2289-2297
  • DOI: 10.1007/s00277-018-3443-1
  • Peer Reviewed
• [Journal Article] Relationship between clinical features and somatic gene mutations in myelodysplastic syndrome (2018)
  • Author(s): 平沢 伸広、小川 誠司、長谷川 雄一、千葉 滋、坂田（柳元） 麻実子、南谷 泰仁、服部 圭一郎、末原 泰人、加藤 貴康、横山 泰久、栗田 尚樹、小原 直
  • Journal Title: Jpn. J. Clin. Hematol. Volume: 59 Issue: 1 Pages: 80-83
  • DOI: 10.11406/rinketsu.59.80
  • NAID: 130006337948
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Liquid biopsy for the identification of intravascular large B-cell lymphoma (2018)
  • Author(s): Suehara Yasuhito、Sakata-Yanagimoto Mamiko、et al
  • Journal Title: Haematologica Volume: in press
  • DOI: 10.3324/haematol.2017.178830
  • Peer Reviewed / Open Access
• [Journal Article] Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan (2018)
  • Author(s): Y. Ueda, N. Obara, Y. Yonemura, H. Noji, M. Masuko, Y. Seki, K. Wada, T. Matsuda, H. Akiyama, T. Ikezoe, S. Chiba, Y. Kanda, T. Kawaguchi, T. Shichishima, H. Nakakuma, S. Okamoto, J. Nishimura, Y. Kanakura, H. Ninomiya
  • Journal Title: International Journal of Hematology Volume: epub Pages: 1-10
  • DOI: 10.1007/s12185-018-2409-3
  • Peer Reviewed
• [Journal Article] Clinical significance of disease-specific MYD88 mutations in circulating DNA in primary central nervous system lymphoma (2018)
  • Author(s): Hattori Keiichiro、Sakata-Yanagimoto Mamiko、Suehara Yasuhito、Yokoyama Yasuhisa、Kato Takayasu、Kurita Naoki、Nishikii Hidekazu、Obara Naoshi、Takano Shingo、Ishikawa Eiichi、Matsumura Akira、Hasegawa Yuichi、Chiba Shigeru
  • Journal Title: Cancer Science Volume: 109 Pages: 225-230
  • DOI: 10.1111/cas.13450
  • NAID: 120007134545
  • Peer Reviewed / Open Access
• [Journal Article] Chronic Graft-versus-host Disease Presenting with Multiple Punctate Intracranial Lesions on Contrast-enhanced Magnetic Resonance Imaging (2017)
  • Author(s): Terada M, Nakamagoe K, Obara N, Ogawa S, Sakamoto N, Sato T, Nohara S, Chiba S, Tamaoka A.
  • Journal Title: Intern. Med. Volume: 56 Issue: 3 Pages: 363-368
  • DOI: 10.2169/internalmedicine.56.7329
  • NAID: 130005310315
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study) (2017)
  • Author(s): Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Tohyama K, et al
  • Journal Title: Am J Hematol. Volume: 92 Pages: 1324-1332
  • DOI: 10.1002/ajh.24905
  • Peer Reviewed / Open Access
• [Journal Article] A single institutional retrospective evaluation for younger patients with primary central nervous lymphomas on a modified R-MPV regimen followed by radiotherapy and high dose cytarabine (2017)
  • Author(s): Hattori Keiichiro、Sakata-Yanagimoto Mamiko、Okoshi Yasushi、Kato Takayasu、Kurita Naoki、Yokoyama Yasuhisa、Obara Naoshi、Takano Shingo、Ishikawa Eiichi、Yamamoto Tetsuya、Matsumura Akira、Hasegawa Yuichi、Chiba Shigeru
  • Journal Title: J Clin Exp Hematopathol Volume: 57 Issue: 2 Pages: 41-46
  • DOI: 10.3960/jslrt.17012
  • NAID: 130006854539
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] Detection of the circulating tumor DNAs in angioimmunoblastic T- cell lymphoma (2017)
  • Author(s): Sakata-Yanagimoto Mamiko、Nakamoto-Matsubara Rie、Komori Daisuke、Nguyen Tran B.、Hattori Keiichiro、Nanmoku Toru、Kato Takayasu、Kurita Naoki、Yokoyama Yasuhisa、Obara Naoshi、Hasegawa Yuichi、Shinagawa Atsushi、Chiba Shigeru
  • Journal Title: Annals of Hematology Volume: 96 Pages: 1471-1475
  • DOI: 10.1007/s00277-017-3038-2
  • Peer Reviewed / Open Access
• [Journal Article] A phase I/II trial of intrabone marrow cord blood transplantation and comparison of the hematological recovery with the Japanese nationwide database (2017)
  • Author(s): Kurita N, Gosho M, Yokoyama Y, Kato T, Obara N, Sakata-Yanagimoto M, Hasegawa Y, Uchida N, Takahashi S, Kouzai Y, Atsuta Y, Kurata M, Ichinohe T, Chiba S
  • Journal Title: Bone marrow transplantation Volume: 52 Pages: 574-579
  • DOI: 10.1038/bmt.2016.319
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 再生不良性貧血治療の最前線 (2017)
  • Author(s): 小原 直
  • Journal Title: 臨床血液 Volume: 58 Pages: 1851-1859
  • NAID: 130006132645
  • Peer Reviewed / Open Access
• [Journal Article] Haploidentical transplantation using post-transplant high-dose cyclophosphamide for adult T-cell lymphoma after mogamulizumab treatment (2017)
  • Author(s): 日下部 学、栗田 尚樹、錦井 秀和ら
  • Journal Title: Jpn. J. Clin. Hematol. Volume: 58 Issue: 5 Pages: 449-454
  • DOI: 10.11406/rinketsu.58.449
  • NAID: 130005690164
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed / Open Access
• [Presentation] 特発性血小板減少性紫斑病患者における血清エルトロンボパグ濃度が肝障害発現に及ぼす影響 (2019)
  • Author(s): 柳町 直哉、小原 直, 横山 泰久, 錦井 秀和, 坂田（柳元）麻実子, 長谷川 雄一, 大越 靖, 千葉 滋, 土岐 浩介, 本間 真人
  • Organizer: 第81回 日本血液学会学術集会
• [Presentation] 地固め療法中に骨髄壊死を認めたフィラデルフィア染色体陽性急性リンパ芽球性白血病、地固め療法中に骨髄壊死を認めたフィラデルフィア染色体陽性急性リンパ芽球性白血病 (2019)
  • Author(s): 石塚 幹太郎, 小原 直，坂本 竜弘，加藤 貴康，日下部 学，栗田 尚樹，横山 泰久，錦井 秀和，坂田（柳元）麻実子，長谷川 雄一，千葉 滋
  • Organizer: 第81回 日本血液学会学術集会
• [Presentation] The relationship between the pretreatment PNH clone size and clinical course in patients with bone marrow failure syndromes: Interim analysis of Japanese multicenter prospective study (2019)
  • Author(s): asutaka Ueda、Kohei Hosokawa, Ken Ishiyama, Hiroyuki Takamori, Yuji Yonemura, Naoshi Obara, Hideyoshi Noji, Hiroshi Takahashi, Yukari Shirasugi, Takahisa Matsuda, Kiyoshi Ando, Tsutomu Shichishima, Takayuki Ikezoe, Shigeru Chiba, Haruhiko Ninomiya, Tatsuya Kawaguchi, Jun-ichi Nishimura, Yuzuru Kanakura, Shinji Nakao
  • Organizer: The 24th Congress of EHA
  • Int'l Joint Research
• [Presentation] Targeting T-cell receptor signaling pathway by dasatinib in relapsed/refractory angioimmunoblastic T-cell lymphoma (2019)
  • Author(s): usuke Kiyoki、Mamiko Sakata-Yanagimoto, Tran B. Nguyen, Manabu Fujisawa, Yasuhito Nanya, Kantaro Ishitsuka, Haruka Momose, Shinichiro Sukegawa, Atsushi Shinagawa, Takuya Suyama, Yuji Sato, Hidekazu Nishikii, Naoshi Obara et al.
  • Organizer: The 24th Congress of EHA
  • Int'l Joint Research
• [Presentation] Notch signaling in nestin-expressing bone marrow stromal cells supports erythropoietic niche (2019)
  • Author(s): Tatsuhiro Sakamoto、Naoshi Obara, Hidekazu Nishikii, Takayasu Kato, Cao Sy Luan, Ryosuke Fujimura, Mamiko Sakata-Yanagimoto, Satoru Takahashi, Shigeru Chiba
  • Organizer: The 10th JSH INTERNATIONAL SYMPOSIUM 2019 in Ise-Shima
  • Int'l Joint Research
• [Presentation] Targeted sequencing and IgH rearrangement status revealed branching evolution pattern of SMZL and DLBCL (2019)
  • Author(s): Manabu Kusakabe、Mamiko Sakata-Yanagimoto, Yasuhito Suehara, Keiichiro Hattori, Toru Nanmoku, Tatsuhiro Sakamoto, Yasuhisa Yokoyama, Takayasu Kato, Naoki Kurita, Hidekazu Nishikii, Naoshi Obara, Masafumi Muratani, Yuichi Hasegawa, Shigeru Chiba
  • Organizer: The 10th JSH INTERNATIONAL SYMPOSIUM 2019 in Ise-Shima
  • Int'l Joint Research
• [Presentation] 後天性血小板機能異常により顕著な出血傾向を呈し，急速な経過を辿った原発性骨髄線維症の1例 (2019)
  • Author(s): 百瀬 春佳、錦井 秀和，上妻 行則，堤（太田）育代，吉田 近思，米野 琢哉，助川 慎一郎，石塚 幹太郎，槇島 健一，日下部 学，横山 泰久，加藤 貴康，栗田 尚樹，坂田（柳元）麻実子，小原 直，長谷川 雄一，千葉 滋
  • Organizer: 第10回 日本血液学会関東甲信越地方会
• [Presentation] ブスルファン投与に伴う幻覚の解析 (2019)
  • Author(s): 栗田 尚樹, 坂本 竜弘，加藤 貴康，日下部 学，横山 泰久，錦井 秀和，坂田（柳元）麻実子，小原 直，長谷川 雄一，千葉 滋
  • Organizer: 第41回日本造血細胞移植学会総会
• [Presentation] 骨髄破壊的前処置を用いたHLA半合致移植の第I/II相研究 (2018)
  • Author(s): 栗田尚樹、横山泰久，坂本竜弘，加藤貴康，日下部 学，錦井秀和，坂田（柳元）麻実子，小原 直，小川晋一，周山卓也，馬場直子，長谷川雄一，千葉 滋
  • Organizer: 第40回日本造血細胞移植学会総会
• [Presentation] 生着不全に対するmodified 1-day regimenを用いた臍帯血移植の検討 (2018)
  • Author(s): 須摩桜子、横山泰久，石塚幹太郎，助川慎一郎，槇島健一，清木祐介，馬場直子，坂本竜弘，日下部 学，加藤貴康，錦井秀和，栗田尚樹，坂田（柳元）麻実子，小原 直，長谷川雄一，千葉 滋
  • Organizer: 第40回日本造血細胞移植学会総会
• [Presentation] 同種移植後10年以上経過したのちに再発を認めた成人T細胞白血病／リンパ腫 (2018)
  • Author(s): 助川慎一郎, 横山泰久，石塚幹太郎，百瀬春佳，須摩桜子，清木祐介，馬場直子，真家絋一郎，坂本竜弘，日下部学，錦井秀和，加藤貴康，栗田尚樹，坂田（柳元）麻実子，小原 直，長谷川雄一，千葉 滋
  • Organizer: 第8回 日本血液学会関東甲信越地方会
• [Presentation] 造血幹細胞移植における入院期間と医療費の検討 (2018)
  • Author(s): 栗田尚樹, 坂本竜弘，加藤貴康，日下部学，錦井秀和，横山泰久，坂田（柳元）麻実子，小原 直，長谷川雄一，千葉 滋
  • Organizer: 第115回 日本内科学会
• [Presentation] 成人慢性好中球減少症の予後追跡調査 (2018)
  • Author(s): 横山泰久, 小原 直，五所正彦，鈴木隆浩，高見昭良，宮崎泰司，赤司浩一，千葉 滋
  • Organizer: 第115回 日本内科学会
• [Presentation] "TP53 mutations found in the serum of malignant lymphoma patients at remission derive from clonal hematopoiesis rather than minimal residual disease. " (2018)
  • Author(s): Yasuhito Suehara, Mamiko Sakata-Yanagimoto, Keiichiro Hattori, Taiki Sato, Masayuki Noguchi, Tatsuhiro Sakamoto, Manabu Kusakabe, Naoki Kurita, Takayasu Kato, Yasuhisa Yokoyama, Hidekazu Nishikii, Naoshi Obara, Yuichi Hasegawa, Shigeru Chiba
  • Organizer: 2018 ASH Meeting on Lymphoma Biology
  • Int'l Joint Research
• [Presentation] Bone Marrow Erythropoiesis is Maintained by Notch Signaling in Specific Bone Marrow (2018)
  • Author(s): Tatsuhiro Sakamoto, Naoshi Obara, Hidekazu Nishikii, Takayasu Kato, Ryosuke Fujimura, Cao Sy Luan, Mamiko Sakata- Yanagimoto, Satoru Takahashi, Shigeru Chiba
  • Organizer: The 9th JSH International Symposium 2018 in Kyoto
  • Int'l Joint Research
• [Presentation] 原発性寒冷凝集素症の溶血発作に対してエクリズマズが著効した一例 (2018)
  • Author(s): 槇島 健一, 小原 直, 石塚幹太郎, 助川慎一郎, 須摩桜子, 清木祐介, 馬場直子, 坂本竜弘, 日下部学, 加藤貴康, 錦井秀和, 栗田尚樹, 横山泰久, 坂田（柳元）麻実子, 長谷川雄一, 千葉 滋
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] 再生不良性貧血に対する2回目の免疫抑制療法の単施設における経験 (2018)
  • Author(s): 坂本竜弘, 小原 直, 加藤貴康, 栗田尚樹, 日下部学, 錦井秀和, 坂田（柳元）麻実子, 長谷川雄一, 千葉 滋
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] 成人慢性好中球減少症の診療に関する全国調査 -第2報- (2018)
  • Author(s): 横山泰久, 小原 直, 五所正彦, 鈴木隆浩, 高見昭良, 宮崎泰司, 赤司浩一, 千葉 滋
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] エクリズマブ（ソリリス）製造販売後調査（発作性夜間ヘモグロビン尿症）に関する長期観察の中間報告 (2018)
  • Author(s): 野地秀義, 植田康敬, 小原 直, 神田善伸, 岡本真一郎, 臼杵憲祐, 松田貴久, 秋山仁泉, 高橋正典, 米村雄士, 川口辰哉, 西村純一, 池添隆之, 千葉 滋, 金倉 譲, 二宮治彦
  • Organizer: 第80回日本血液学会学術集会