| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we demonstrated that i) human hematopoietic stem cell (HSC) population contained a subfraction which expressed CD35, an inhibitory molecule of complementary system, ii) CD35+ and CD35- HSCs were comparable in their gene expression pattern and potential about proliferation or lineage differentiation at the steady state, and that iii) CD35+HSCs preferentially survived and proliferated under the stress hematopoiesis (e.g., xenotransplantation and chemotherapies) by escaping the attack of complementary cascade.
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