| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
This study targeted acute myeloid leukemia (AML) and aimed to identify new therapeutic targets and overcome leukemia by clarifying the interaction between AML cells and bone marrow microenvironment (bone marrow stromal cells). As a result of the research, when NOTCH signal was knocked out in the whole bone marrow microenvironment, the proliferation of AML cells was enhanced. Leukemic mice, which are recipient mice lacking the NOTCH signal in the whole bone marrow microenvironment, died very early after transplantation and were difficult to analyze. Therefore, we created conditional knock out mice that lack the NOTCH signal only in specific bone marrow stromal cells. We discovered that this mouse causes a differentiation disorder in the erythroid lineage, and AML mouse model using this mouse is currently being analyzed.
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