Basic construction of WT1-targetting CAR-T therapy for acute myeloid leukemia

• Project/Area Number: 17K09923
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Mie University
• Principal Investigator: Katayama Naoyuki 三重大学, 医学系研究科, 教授 (20185812)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 血液内科学 / 造血器腫瘍 / 急性骨髄性白血病 / 白血病幹細胞 / CD25 / 造血幹細胞 / B1細胞 / CAR-T療法 / WT1

Outline of Final Research Achievements

We examined leukemic stem cell (LSC) properties of CD25-positive acute myeloid leukemia (AML), using a patient-derived xenograft model and an in vitro culture system. The expression of CD25 fluctuated in LSCs in CD25-positive AML, suggesting that targeting CD25 may not be effective for eradicating LSCs of CD25-positive AML.
We analyzed peripheral blood cells from patients with paroxysmal nocturnal hemoglobinemia (PNH), a clonal disorder of hematopoietic stem cells (HSCs) caused by somatic mutations in PIGA. Importantly, the PIGA-mutated HSCs retain their multilineage differentiation capacity. We separated and investigated the mutated cells. The results suggest that a small, but distinct, proportion of B1 cells may be derived from adult HSCs. The similar data were obtained with peripheral blood cells from patients with chronic myelogenous leukemia, a clonal disorder of HSCs with their multilineage differentiation capacity except for T-cell lineage.

Academic Significance and Societal Importance of the Research Achievements

造血器悪性腫瘍の中でがん幹細胞の存在が明白である急性骨髄性白血病（AML）に対する白血病幹細胞に対する分子標的療法の開発は、AMLの治療成績の改善に必須である。そのような状況の中では、標的分子の同定が必要とされ、その同定には緻密な検討が要求される。今回の研究成果は最適な分子の同定を再認識させる意義のあるものである。ヒトB1細胞の機能は不明な点も多い。この細胞の生物学的特性を明らかにしていくことで、様々な免疫反応や自己免疫疾患のメカニズムを検討していくことは、疾患の病態解明や治療法の開発に有用な情報を提供するものである。

Research Products

• [Journal Article] Guest editorial: B1 cells: their ontogeny and malignant counterpart (2020)
  • Author(s): Katayama N
  • Journal Title: International Journal of Hematology Volume: 111 Issue: 5 Pages: 619-621
  • DOI: 10.1007/s12185-020-02868-z
  • Peer Reviewed
• [Journal Article] Ontogeny of human B1 cells (2020)
  • Author(s): Kageyama Y, Katayama N
  • Journal Title: International Journal of Hematology Volume: 111 Issue: 5 Pages: 628-633
  • DOI: 10.1007/s12185-019-02775-y
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy. (2020)
  • Author(s): Sawaki A, Miyazaki K, Yamaguchi M, Takeuchi T, Kobayashi K, Imai H, Tawara I, Ono R, Nosaka T, Katayama N.
  • Journal Title: Int J Hematol Volume: 111 Issue: 5 Pages: 686-691
  • DOI: 10.1007/s12185-020-02832-x
  • Peer Reviewed
• [Journal Article] First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors. (2020)
  • Author(s): Ishihara M, Tono Y, Miyahara Y, Muraoka D, Harada N, Kageyama S, Sasaki T, Hori Y, Soga N, Uchida K, Shiraishi T, Sato E, Kanda H, Mizuno T, Webster GA, Ikeda H, Katayama N, Sugimura Y, Shiku H.
  • Journal Title: Cancer Immunol Immunother Volume: 69 Issue: 4 Pages: 663-675
  • DOI: 10.1007/s00262-020-02483-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Achievement of long-term remission of disseminated histoplasmosis in an AIDS patient (2020)
  • Author(s): Nakamura A, Tawara I, Ino K, Matsumoto T, Hayashi A, Imai H, Muraosa Y, Kamei K, Katayama N
  • Journal Title: Medical Mycology Case Reports Volume: 27 Pages: 25-28
  • DOI: 10.1016/j.mmcr.2019.12.012
  • Peer Reviewed / Open Access
• [Journal Article] Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells (2020)
  • Author(s): Tanaka A, Katayama N, et al (他21名, 21番目)
  • Journal Title: Journal of Experimental Medicine Volume: 217 Issue: 2
  • DOI: 10.1084/jem.20191009
  • Peer Reviewed / Open Access
• [Journal Article] DA-EPOCH-R combined with high-dose methotrexate in patients with newly diagnosed stage II-IV CD5-positive diffuse large B-cell lymphoma: a single-arm, open-label, phase 2 study (2020)
  • Author(s): Miyazaki K, Asano N, Yamada T, Miyawaki K, Sakai R, Igarashi T, Nishikori M, Ohata K, Sunami K, Yoshida I, Yamamoto G, Takahashi N, Okamoto M, Yano H, Nishimura Y, Tamaru S, Nishikawa M, Izutsu K, Kinoshita T, Suzumiya J, Ohshima K, Kato K, Katayama N, Yamaguchi M
  • Journal Title: Haematologica Volume: - Issue: 9 Pages: 2308-2315
  • DOI: 10.3324/haematol.2019.231076
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein (2019)
  • Author(s): Ikemura Kenji、Hiramatsu Shun-ichi、Shinogi Yuri、Nakatani Yusuke、Tawara Isao、Iwamoto Takuya、Katayama Naoyuki、Okuda Masahiro
  • Journal Title: Scientific Reports Volume: 9 Issue: 1
  • DOI: 10.1038/s41598-019-56900-2
  • Peer Reviewed / Open Access
• [Journal Article] Clinical utility of molecular diagnosis of blood stream infections in allogeneic hematopoietic stem cell transplantation recipients with hematologic malignancies. (2019)
  • Author(s): Fujieda A, Nakase K, Nakamura A, Ohishi K, Sugimoto Y, Monma F, Masuya M, Katayama N
  • Journal Title: Advances in Microbiology Volume: 9 Issue: 12 Pages: 971-982
  • DOI: 10.4236/aim.2019.912062
  • Peer Reviewed
• [Journal Article] Evaluation of Medication Adherence and Pharmacokinetics of Dasatinib for Earlier Molecular Response in Japanese Patients With Newly Diagnosed Chronic Myeloid Leukemia (2019)
  • Author(s): Iwamoto Takuya、Monma Fumihiko、Ohishi Kohshi、Umino Akira、Suzuki Kei、Oka Koji、Kawakami Keiki、Sekine Takao、Okuda Masahiro、Katayama Naoyuki
  • Journal Title: Therapeutic Drug Monitoring Volume: 41 Issue: 5 Pages: 575-581
  • DOI: 10.1097/ftd.0000000000000639
  • Peer Reviewed
• [Journal Article] Life-threatening tongue and retropharyngeal hemorrhage in a patient with Hemophilia A with inhibitors (2019)
  • Author(s): Kageyama Y, Matsumoto T, Tawara I, Wada H, Katayama N
  • Journal Title: American Journal of Case Reports Volume: 20 Pages: 1022-1026
  • DOI: 10.12659/ajcr.916151
  • Peer Reviewed / Open Access
• [Journal Article] A population of CD20+CD27+CD43+CD38lo/int B1 cells in PNH are missing GPI-anchored proteins and harbor PIGA mutations (2019)
  • Author(s): Kageyama Y, Miwa H, Tawara I, Ohishi K, Masuya M, Katayama N
  • Journal Title: Blood Volume: 134 Issue: 1 Pages: 89-92
  • DOI: 10.1182/blood.2019001343
  • Peer Reviewed
• [Journal Article] Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin (2019)
  • Author(s): Yamaguchi M, Suzuki R, Miyazaki K, Amaki J, Takizawa J, Sekiguchi N, Kinoshita S, Tomita N, Wada H, Kobayashi Y, Niitsu N, Ando T, Maeda T, Saito B, Matsuoka H, Sakai R, Kubota N, Masaki Y, Kameoka Y, Asano N, Oguchi M, Katayama N
  • Journal Title: Annals of Hematology Volume: 98 Issue: 7 Pages: 1647-1655
  • DOI: 10.1007/s00277-019-03689-9
  • Peer Reviewed
• [Journal Article] Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk (2019)
  • Author(s): Suzuki Kei、Wada Hideo、Matsumoto Takeshi、Ikejiri Makoto、Ohishi Kohshi、Yamashita Yoshiki、Imai Hiroshi、Iba Toshiaki、Katayama Naoyuki
  • Journal Title: Thrombosis Journal Volume: 17 Issue: 1 Pages: 1-8
  • DOI: 10.1186/s12959-019-0201-0
  • Peer Reviewed / Open Access
• [Journal Article] Infiltrating CCR2+ monocytes and their progenies, fibrocytes, contribute to colon fibrosis by inhibiting collagen degradation through the production of TIMP-1 (2019)
  • Author(s): Kuroda N, Masuya M, Tawara I, Tsuboi J, Yoneda M, Nishikawa K, Kageyama Y, Hachiya K, Ohishi K, Miwa H, Yamada R, Hamada Y, Tanaka K, Kato T, Takei Y, Katayama N
  • Journal Title: Scientific Reports Volume: 9 Issue: 1
  • DOI: 10.1038/s41598-019-45012-6
  • Peer Reviewed / Open Access
• [Journal Article] Successful management of immune thrombocytopenia presenting with lethal alveolar hemorrhage (2019)
  • Author(s): Nagaharu K, Masuya M, Kawakami K, Katayama N
  • Journal Title: Case Reports in Hematology Volume: 2019 Pages: 1-4
  • DOI: 10.1155/2019/5170282
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological features of TAFRO syndrome complicated by acquired hemophilia A and development of cardiopulmonary arrest that were successfully treated with VA-ECMO and tocilizumab (2019)
  • Author(s): Suzuki Kei、Matsumoto Takeshi、Iwashita Yoshiaki、Ishikura Ken、Fujioka Masaki、Wada Hideo、Katayama Naoyuki、Imai Hiroshi
  • Journal Title: International Journal of Hematology Volume: - Issue: 6 Pages: 737-743
  • DOI: 10.1007/s12185-019-02604-2
  • Peer Reviewed
• [Journal Article] Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy (2019)
  • Author(s): Yamashita Yoshiki、Suzuki Kei、Mastumoto Takeshi、Ikejiri Makoto、Ohishi Koji、Katayama Naoyuki、Suzuki-Inoue Katsue、Wada Hideo
  • Journal Title: Thrombosis Research Volume: 178 Pages: 54-58
  • DOI: 10.1016/j.thromres.2019.03.018
  • Peer Reviewed
• [Journal Article] Comments to: an evaluation of hemostatic abnormalities in patients with hemophilia by APTT waveform, peak heights of APTT waveform are useful for diagnosing hemophilia or inhibitor (2019)
  • Author(s): Matsumoto T, Wada H, Ohishi K, Yamashita Y, Ikejiri M, Katayama N
  • Journal Title: Clin Appl Thromb Hemost Volume: 印刷中
  • DOI: 10.1177/1076029618824419
  • Peer Reviewed
• [Journal Article] Esophageal squamous cell neoplasia is an independent negative prognostic factor for head and neck cancer patients (2018)
  • Author(s): Hamada Y, Mizuno T, Tanaka K, Katsurahara M, Horiki N, Yamada R, Inoue H, Takei Y, Katayama N
  • Journal Title: Int J Clin Oncol Volume: 23 Issue: 2 Pages: 243-248
  • DOI: 10.1007/s10147-017-1201-3
  • Peer Reviewed
• [Journal Article] The evaluation of D-dimer levels for the comparison of fibrinogen and fibrin units using different D-dimer kits to diagnose VTE (2018)
  • Author(s): Hasegawa M, Wada H, Yamaguchi T, Wakabayashi H, Fujimoto N, Matsumoto T, Hasegawa K, Yamada N, Ito M, Yamashita Y, Katayama N, Nakatani K, Sudo A
  • Journal Title: Clin Appl Thromb Hemost Volume: 24 Issue: 4 Pages: 655-662
  • DOI: 10.1177/1076029617706755
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Successful treatment of primary bone marrow Hodgkin lymphoma with brentuximab vedotin: a case report and review of the literature (2018)
  • Author(s): Nagaharu K, Masuya M, Kageyama Y, Yamaguchi T, Ito R, Kawakami K, Ito M, Katayama N
  • Journal Title: J Med Case Rep Volume: 12 Issue: 1 Pages: 151-151
  • DOI: 10.1186/s13256-018-1693-0
  • Peer Reviewed / Open Access
• [Journal Article] Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes (2018)
  • Author(s): Goto I, Okamoto R, Hashizume R, Suzuki N, Ito R, Yamanaka K, Saito H, Kiyonari H, Tawara I, Kageyama Y, Ogihara Y, Ali Y, Yamada N, Katayama N, Ito M
  • Journal Title: PLoS One Volume: 13 Issue: 5 Pages: e0197078-e0197078
  • DOI: 10.1371/journal.pone.0197078
  • Peer Reviewed / Open Access
• [Journal Article] Early disease progression in patients with localized NK/T-cell lymphoma treated with concurrent chemoradiotherapy. (2018)
  • Author(s): Yamaguchi M, Suzuki R, Kim SJ, Ko YH, Oguchi M, Asano N, Miyazaki K, Terui Y, Kubota N, Maeda T, Kobayashi Y, Amaki J, Soejima T, Saito B, Shimoda E, Fukuhara N, Tsukamoto N, Shimada K, Choi I, Utsumi T, Ejima Y, Kim WS, Katayama N.
  • Journal Title: Cancer Sci Volume: - Issue: 6 Pages: 2056-2062
  • DOI: 10.1111/cas.13597
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-2/IL-3 interplay mediates growth of CD25 positive acute myeloid leukemia cells (2018)
  • Author(s): Nakase K, Kita K, Katayama N
  • Journal Title: Med Hypotheses Volume: 115 Pages: 5-7
  • DOI: 10.1016/j.mehy.2018.03.007
  • Peer Reviewed
• [Journal Article] Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti-factor IXa/factor X bispecific antibody emicizumab: comment (2018)
  • Author(s): Matsumoto T, Wada H, Toyoda H, Hirayama M, Yamashita Y, Katayama N
  • Journal Title: J Thromb Haemost Volume: - Issue: 8 Pages: 1665-1666
  • DOI: 10.1111/jth.14190
  • Peer Reviewed
• [Journal Article] Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy (2018)
  • Author(s): Wada H, Matsumoto T, Suzuki K, Imai H, Katayama N, Iba T, Matsumoto M
  • Journal Title: Thromb J Volume: 16 Issue: 1 Pages: 14-14
  • DOI: 10.1186/s12959-018-0168-2
  • Peer Reviewed / Open Access
• [Journal Article] An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform. (2018)
  • Author(s): Katayama H, Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Habe K, Katayama N:
  • Journal Title: Clin Appl Thromb Hemost Volume: open ac Issue: 7 Pages: 1170-1176
  • DOI: 10.1177/1076029618757344
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical manifestation of patients with atypical hemolytic uremic syndrome with the C3 p.I1157T variation in the Kinki region of Japan. (2018)
  • Author(s): Matsumoto T, Toyoda H, Amano K, Hirayama M, Ishikawa E, Fujimoto M, Ito M, Ohishi K, Katayama N, Yoshida Y, Matsumoto M, Kawamura N, Ikejiri M, Kawakami K, Miyata T, Wada H
  • Journal Title: Clin Appl Thromb Hemost Volume: 24 Issue: 8 Pages: 1301-1307
  • DOI: 10.1177/1076029618771750
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of CD25 fluctuates in the leukemia-initiating cell population of CD25-positive AML (2018)
  • Author(s): Kageyama Y, Miwa H, Arakawa R, Tawara I, Ohishi K, Masuya M, Nakase K, Katayama N
  • Journal Title: PLoS One Volume: 13 Issue: 12 Pages: e0209295-e0209295
  • DOI: 10.1371/journal.pone.0209295
  • Peer Reviewed / Open Access
• [Journal Article] Monitoring of hemostatic abnormalities in major orthopedic surgery patients treated with edoxaban by APTT waveform (2018)
  • Author(s): Hasegawa M, Wada H, Tone S, Yamaguchi T, Wakabayashi H, Ikejiri M, Watanabe M, Fujimoto N, Matsumoto T, Ohishi K, Yamashita Y, Katayama N, Sudo A
  • Journal Title: Int J Lab Hematol Volume: 40 Issue: 1 Pages: 49-55
  • DOI: 10.1111/ijlh.12727
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An Evaluation of the Activated Partial Thromboplastin Time Waveform (2017)
  • Author(s): Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Hasegawa K, Suzuki K, Imai H, Nakatani K, Katayama N
  • Journal Title: Clin Appl Thromb Hemost Volume: Epub Issue: 5 Pages: 764-770
  • DOI: 10.1177/1076029617724230
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis (2017)
  • Author(s): Habe K, Wada H, Higashiyama A, Akeda T, Tsuda K, Mori R, Kakeda M, Matsumoto T, Ohishi K, Yamanaka K, Katayama N, Mizutani H.
  • Journal Title: Clin Appl Thromb Hemost Volume: 23 Issue: 6 Pages: 622-630
  • DOI: 10.1177/1076029617736382
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study. (2017)
  • Author(s): Ikemura K, Oshima K, Enokiya T, Okamoto A, Oda H, Mizuno T, Ishinaga H, Muraki Y, Iwamoto T, Takeuchi K, Katayama N, Okuda M
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 印刷中 Issue: 5 Pages: 943-949
  • DOI: 10.1007/s00280-017-3296-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Eya2, a target activated by Plzf, is critical for PLZF-RARA-induced leukemogenesis. (2017)
  • Author(s): Ono R, Masuya M, Ishii S, Katayama N, Nosaka T.
  • Journal Title: Mol Cell Biol Volume: 印刷中 Issue: 13
  • DOI: 10.1128/mcb.00585-16
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CXCL12-CXCR4 axis is required for contact-mediated human B lymphoid and plasmacytoid dendritic cell differentiation but not T lymphoid generation. (2017)
  • Author(s): Minami H, Nagaharu K, Nakamori Y, Ohishi K, Shimojo N, Kageyama Y, Matsumoto T, Sugimoto Y, Tawara I, Masuya M, Miwa H, Katayama N.
  • Journal Title: J Immunol. Volume: 199 Issue: 7 Pages: 2343-2355
  • DOI: 10.4049/jimmunol.1700054
  • Peer Reviewed
• [Journal Article] Attempt to Harvest a Sufficient Number of Mononuclear Cells in an Appropriate Blood Product Volume By Modification of the Default Apheresis Setting. (2017)
  • Author(s): Tanaka Y, Ohishi K, Sawai T, Iwasaki H, Kageyama S, Masuya M, Matsumoto T, Tanigawa T, Wada H, Shiku H, Ito M, Katayama N
  • Journal Title: Ther Apher Dial. Volume: 21 Issue: 5 Pages: 507-511
  • DOI: 10.1111/1744-9987.12562
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical Utility of Wilms' Tumor 1 Monitoring in Patients with Myeloid Malignancy and Prior Allogeneic Hematopoietic Stem Cell Transplantation (2017)
  • Author(s): Ino K, Fuji S, Tajima K, Tanaka T, Okinaka K, Inamoto Y, Kurosawa S, Kim SW, Katayama N, Fukuda T
  • Journal Title: Biol Blood Marrow Transplant Volume: 23 Issue: 10 Pages: 1780-1787
  • DOI: 10.1016/j.bbmt.2017.06.007
  • Peer Reviewed / Open Access
• [Journal Article] Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS. (2017)
  • Author(s): Tawara I, Kageyama S, Miyahara Y, Fujiwara H, Nishida T, Akatsuka Y, Ikeda H, Tanimoto K, Terakura S, Murata M, Inaguma Y, Masuya M, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Naoe T, Emi N, Yasukawa M, Katayama N, Shiku H.
  • Journal Title: Blood Volume: 130 Issue: 18 Pages: 1985-1994
  • DOI: 10.1182/blood-2017-06-791202
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study) (2017)
  • Author(s): Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Tohyama K, et al
  • Journal Title: American Journal of Hematology Volume: 92 Issue: 12 Pages: 1324-1332
  • DOI: 10.1002/ajh.24905
  • Peer Reviewed / Open Access
• [Presentation] Gene polymorphisms and vincristine-induced neuropathy in patients who received R-CHOP chemotherapy (2019)
  • Author(s): Sawaki A, Miyazaki K, Takeuchi T, Kobayashi K, Imai H, Tawara I, Ono R, Nosaka T, Yamaguchi M, Katayama N
  • Organizer: 第61回アメリカ血液学会
• [Presentation] Novel lymphoid pathway of human plasmacytoid and conventional dendritic cells (2019)
  • Author(s): Nagaharu K, Ohishi K, Katayama N
  • Organizer: 第61回アメリカ血液学会
• [Presentation] シクロフォスファミド抵抗性腫瘍細胞株を用いたマウスMHC半合致移植モデルの作製 (2019)
  • Author(s): 俵 功、西村廣明、坪井順哉、伊野和子、景山裕紀、大石晃嗣、桝屋正浩、片山直之
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] 十二指腸濾胞性リンパ腫における遺伝子変異と浸潤部位 (2019)
  • Author(s): 宮﨑香奈、竹内俊文、山口素子、浅野直子、澤木昭彦、今井 裕、小埜良一、野阪哲哉、小林一彦、田中匡介、片山直之
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] 原発性骨髄線維症に伴う糸球体腎炎と蛋白尿に対してルキソリチニブが有効であった1例 (2019)
  • Author(s): 西村美砂、永春圭規、杉本由香、大石晃嗣、村田智博、桝屋正浩、片山直之
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] 新規薬剤時代におけるIgD型形質細胞白血病に対するタンデム自家／同種移植の経験 (2019)
  • Author(s): 蜂矢健介、藤枝敦史、鈴木和貴、宮下博之、桝屋正浩、片山直之
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] 赤芽球系・巨核球系に異形成を伴ったcryptic PML-RARAと複雑染色体を有する治療関連APL (2019)
  • Author(s): 加島江美子、杉本由香、俵 功、桝屋正浩、片山直之
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] CML患者における第二世代チロシンキナーゼ阻害薬ダサチニブによる血中PSA値の変化 (2019)
  • Author(s): 大石晃嗣、佐々木 豪、高橋直人、片山直之
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] ヒトB1細胞の一部は成人造血幹細胞に由来する (2019)
  • Author(s): 景山裕紀、三輪啓志、俵 功、大石晃嗣、桝屋正浩、片山直之
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] シクロホスファミド抵抗性の腫瘍細胞株を用いたマウスMHC半合致移植モデル (2019)
  • Author(s): 梅澤紘子、俵功、坪井順哉、伊野和子、大石晃嗣、桝屋正浩、宮原慶裕、珠玖洋、片山直之
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] SOD３の発現レベルと腫瘤形成 (2019)
  • Author(s): 神生夏帆、俵 功、坪井順哉、加藤大祐、桝屋正浩、田辺秀之、宮原慶裕、瀬尾尚宏、吉田利通、宮野 悟、珠玖 洋、片山直之
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] NK／T細胞リンパ腫の長期予後と診断治療間隔：NKEA研究の７年追跡調査 (2019)
  • Author(s): 宮﨑香奈、山口素子、鈴木律朗、小口正彦、長谷川正俊、片山直之
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Expression of CD25 fluctuates in leukemia stem cell population of CD25-positive AML (2018)
  • Author(s): Kageyama Y, Miwa H, Arakawa R, Ohishi K, Masuya M, Nakase K, Ishikawa F, Katayama N
  • Organizer: 第23回ヨーロッパ血液学会
  • Int'l Joint Research
• [Presentation] 日本血液学会における医学系研究の利益相反（COL）管理 (2018)
  • Author(s): 片山直之
  • Organizer: 第80回日本血液学会学術集会
  • Invited
• [Presentation] DA-EPOCH-R with high-dose methotrexate (HD-MTX) for CD5+ DLBCL: Primary analysis of PEARL 5 study (2018)
  • Author(s): Miyazaki K, Asano N, Yamada T, Miyawaki K, Takasaki H, Igarashi T, Nishikori M, Ohta K, Sunami K, Yoshida I, Yamamoto G, Takahashi N, Okamoto M, Yano H, Nishimura Y, Tamaru S, Nishikawa M, Izutsu K, Kinoshita T, Suzumiya J, Ohshima K, Kato K, Katayama N, Yamaguchi M
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] An analysis of the activated partial thromboplastin time waveform in patients with DIC (2018)
  • Author(s): Wada H, Matsumoto T, Ohishi K, Katayama N
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] 溶血発作発症後早期にeculizumab投与を行い速やかな改善がみられた非典型的溶血性尿毒症症候群の一例 (2018)
  • Author(s): 松本剛史、塩谷拓也、伊野和子、宮崎香奈、藤枝敦史、杉本由香、俵功、山口素子、大石晃嗣、桝屋正浩、和田英夫、片山直之
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] CCR2+ Monocyte-Derived Ly6C-F4/80+ Fibrocytes Inhibit Collagen Degradation and Contribute to the Development of Colon Fibrosis Via Production of TIMP-1 (2018)
  • Author(s): Masuya M,Kuroda N, Hachiya K, Tawara I, Kageyama Y, Ohishi K, Miwa H, Katayama N
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Incidence and Risk Factors of Central Nervous System Relapse in Localized Extranodal NK/T-Cell Lymphoma, Nasal Type: An Analysis of Nkea Study (2018)
  • Author(s): Miyazaki K, Taguchi S, Oguchi M, Suzuki R, Asano N, Terui Y, Kubota N, Saito Y, Maeda T, Itasaka S, Kobayashi Y, Itami J, Amaki J, Akiba T, Muraya T, Ii N, Soejima T, Yamaguchi M, Katayama N
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Tumor-specific donor lymphocyte infusion for tumor relapse after hematopoietic cell transpoantation (2017)
  • Author(s): Tawara I, Okamori K, Shiku H, Ikeda H, Katayama N
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Impact on survival by the dose of vincristine (VCR) in R-CHOP for elderly patients with DLBCL (2017)
  • Author(s): Miyazaki K, Takeuchi T, Sawaki A, Usui E, Kawakami K, Umino A, Mizutani M, Watanabe Y,Ikeda T, Matsuoka N, Tsukada T, Nakase K, Fukutome T, Yamaguchi M, Katayama N
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Therapeutic outcomes of immunochemotherapy alone in elderly patients with localized gastric DLBCL (2017)
  • Author(s): Takeuchi T, Miyazaki K, Sawaki A, Usui E, Kawakami K, Mizutani M, Watanabe Y, Matsuoka N, Ikeda T, Umino A, Tsukada T, Nakase K, Fukutome T, Tanaka K, Yamaguchi M, Katayama N
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] DA-EPOCH-R with high-dose methotrexate (HD-MTX) for CD5+ DLBCL: Interim results of PEARL5 study (2017)
  • Author(s): Takasaki H, Miyazaki K, Asano N, Yamada T, Igarashi T, Nishikori M, Ohata K, Sunami K, Yamamoto G, Yoshida I, Niitsu N, Okamoto M, Yano H, Nishimura Y, Tamaru S, Ohshima K, Izutsu K, Kinoshita T, Suzumiya J, Nishikawa M, Katayama N, Yamaguchi M
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Early progression of disease in patients with newly diagnosed localized ENKL treated with RT-DeVIC (2017)
  • Author(s): Suzuki R, Yamaguchi M, Oguchi M, Asano N, Miyazaki K, Ueda K, Kubota N, Maeda T, Kobayashi Y, Amaki J, Murayama T, Saito B, Shimoda E, Fukuhara N, Tsukamoto N, Shimada K, Uike N, Utsumi T, Katayama N
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Clinical performance study of a novel JAK2V617F mutation quantitative kits for patients with Ph-MPN (2017)
  • Author(s): Noguchi M, Koike M, Kizaki M, Sugimoto Y, Katayama N, Dobashi N, Usui N, Kirito K, Komatsu N
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Eya2 is critical for an aberrant self-renewal in PLZF-RARA-induced leukemogenesis (2017)
  • Author(s): Ono R, Masuya M, Ishii S, Katayama N, Nosaka T
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Improved Prognosis of Extranodal NK/T-Cell Lymphoma,Nasal Type (ENKL) of Nasal Origin but Not Extranasal Origin: An Analysis of NKEA Study (2017)
  • Author(s): Yamaguchi M, Suzuki R, Miyazaki K, Amaki J, Takizawa J, Sekiguchi N, Inagaki S, Tomita N, Wada H, Kobayasshi Y, Niitsu N, Ando T, Maeda T, Saito B, Matsuoka H, Sasaki R, Kubota N, Masaki Y, Asano N, Oguchi M, Katayama N
  • Organizer: 第59回米国血液学会
• [Book] 血液専門医テキスト改訂第３版 (2019)
  • Author(s): 片山直之
  • Total Pages: 635
  • Publisher: 日本血液学会
• [Book] 血液疾患最新の治療2020-2022 (2019)
  • Author(s): 桝屋正浩、片山直之
  • Total Pages: 390
  • Publisher: 南江堂
  • ISBN: 9784524249787
• [Book] EBM血液疾患の治療 (2018)
  • Author(s): 藤枝敦史、片山直之
  • Total Pages: 567
  • Publisher: 中外医学社
  • ISBN: 9784498225145