Optimization of new generation therapy for NK/T-cell lymphoma in East Asia

• Project/Area Number: 17K09924
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Mie University
• Principal Investigator: Yamaguchi Motoko 三重大学, 医学部附属病院, 講師 (50359767)
• Co-Investigator(Kenkyū-buntansha): 鈴木 律朗 島根大学, 学術研究院医学・看護学系, 准教授 (20280810)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: NK/T細胞リンパ腫 / 新世代治療 / 多施設共同研究 / 国際情報交換 / RT-2/3DeVIC療法 / SMILE療法 / 内科 / 東アジア / 予後予測 / 国際共同研究

Outline of Final Research Achievements

We conducted a retrospective study including patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL) diagnosed between 2000 and 2013 in 31 hospitals in Japan in part in collaborating with Korean researchers. Approximately 25% of patients with localized nasal ENKL experienced progression of disease within 24 months, regardless of treatment regimens. Most patients with extranasal ENKL did not receive new generation therapy due to impaired organ function or poor general condition. The long-term efficacy and safety of RT-DeVIC for newly-diagnosed localized nasal ENKL were confirmed with a median follow-up of 7.9 years.

Academic Significance and Societal Importance of the Research Achievements

本研究により、日本国内におけるENKL新世代治療の実態がさらに明らかにされた。早期増悪や鼻外発症など、新世代治療によっても満たされていない医療ニーズを持つ患者集団の同定は、今後の治療開発の基盤となるものである。依頼により執筆した複数の総説は国内外での治療アプローチを偏りなくレビューしており、すでに多く閲覧および引用されていることから、当初治療コンセンサスレポートの作成で意図した役割を果たしつつある。

Research Products

• [Int'l Joint Research] Samsung Medical Center(韓国)
• [Int'l Joint Research] Samsung Medical Center(韓国)
• [Int'l Joint Research] Samsung Medical Center(韓国)
• [Journal Article] Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin (2019)
  • Author(s): Yamaguchi M, Suzuki R, Miyazaki K, Amaki J, Takizawa J, Sekiguchi N, Kinoshita S, Tomita N, Wada H, Kobayashi Y, Niitsu N, Ando T, Maeda T, Saito B, Matsuoka H, Sakai R, Kubota N, Masaki Y, Kameoka Y, Asano N, Oguchi M, Katayama N
  • Journal Title: Annals of Hematology Volume: 98 Issue: 7 Pages: 1647-1655
  • DOI: 10.1007/s00277-019-03689-9
  • Peer Reviewed
• [Journal Article] Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type (2018)
  • Author(s): Yamaguchi M, Suzuki R, Oguchi M
  • Journal Title: Blood Volume: 131 Issue: 23 Pages: 2528-2540
  • DOI: 10.1182/blood-2017-12-791418
  • Peer Reviewed
• [Journal Article] Early disease progression in patients with localized NK/T-cell lymphoma treated with concurrent chemoradiotherapy. (2018)
  • Author(s): Yamaguchi M, Suzuki R, Kim SJ, Ko YH, Oguchi M, Asano N, Miyazaki K, Terui Y, Kubota N, Maeda T, Kobayashi Y, Amaki J, Soejima T, Saito B, Shimoda E, Fukuhara N, Tsukamoto N, Shimada K, Choi I, Utsumi T, Ejima Y, Kim WS, Katayama N.
  • Journal Title: Cancer Sci Volume: - Issue: 6 Pages: 2056-2062
  • DOI: 10.1111/cas.13597
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extranodal NK/T-cell lymphoma: Updates in biology and management strategies (2018)
  • Author(s): Yamaguchi M, Oguchi M, Suzuki R
  • Journal Title: Best Practice & Research Clinical Haematology Volume: 31 Issue: 3 Pages: 315-321
  • DOI: 10.1016/j.beha.2018.07.002
  • Peer Reviewed
• [Journal Article] Treatment of NK/T-cell lymphoma: current situations and prospectives (2018)
  • Author(s): 山口 素子
  • Journal Title: Rinsho Ketsueki Volume: 59 Issue: 5 Pages: 588-593
  • DOI: 10.11406/rinketsu.59.588
  • NAID: 130007384584
  • ISSN: 0485-1439, 1882-0824
• [Journal Article] Current treatment approaches for NK/T-cell lymphoma (2017)
  • Author(s): Yamaguchi M, Miyazaki K
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 57 Issue: 3 Pages: 98-108
  • DOI: 10.3960/jslrt.17018
  • NAID: 130006286270
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Presentation] Treatment overview of extranodal NK/T-cell lymphoma (2019)
  • Author(s): Yamaguchi M
  • Organizer: ILROG Educational Symposium
  • Int'l Joint Research / Invited
• [Presentation] CLINICAL OUTCOMES AND DIAGNOSIS-TO-TREATMENT INTERVAL IN PATIENTS WITH NK/T-CELL LYMPHOMA: 7-YEAR FOLLOW-UP OF THE NKEA STUDY (2019)
  • Author(s): Yamaguchi M, Suzuki R, Oguchi M, Miyazaki K, Taguchi S, Amaki J, Maeda T, Kubota N, Maruyama D, Terui Y, Sekiguchi N, Takizawa J, Tsukamoto H, Murayama T, Ando T, Matsuoka H, Hasegawa M, Wada H, Sakai R, Kameoka Y, Tsukamoto N, Choi I, Masaki Y, Shimada K, Fukuhara N, Utsumi T, Uoshima N, Kagami Y, Asano N, Katayama N
  • Organizer: 15-ICML International Conference on Malignant Lymphoma
  • Int'l Joint Research
• [Presentation] Seven-year follow-up of 101 patients with advanced NK/T-cell lymphoma: NKEA study (2019)
  • Author(s): Miyazaki K, Suzuki R, Yamaguchi M, Amaki J, Sekiguchi N, Takizawa J, Ando T, Wada H, Masaki Y, Kameoka Y, Murayama T, Asano N, Oguchi M, Katayama N
  • Organizer: The 10th JSH International Symposium 2019 in Ise-Shima
  • Int'l Joint Research
• [Presentation] Long-term outcomes and diagnosis-to-treatment interval in NK/T-cell lymphoma: 7-year follow-up of the NKEA study (2019)
  • Author(s): Miyazaki K, Yamaguchi M, Suzuki R, Oguchi M, Hasegawa M, Katayama N
  • Organizer: 第78回日本癌学会学術集会
• [Presentation] NK/T細胞リンパ腫の長期予後と 診断-治療間隔 (DTI)：NKEA研究 (2019)
  • Author(s): 山口素子、鈴木律朗、小口正彦、宮崎香奈、田口千藏、天木惇、前田猛、久保田靖子、丸山大、照井康仁、関口和、瀧澤淳、塚本裕之、村山徹、安藤寿彦、松岡広、長谷川正俊、和田秀穂、酒井リカ、亀井吉弘、塚本憲史、崔日承、正木康史、島田和之、福原規子、内海貴彦、魚嶋伸彦、鏡味良豊、浅野直子、片山直之 (NKEA project)
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] NK/T-cell lymphoma: SMILE and other “asparaginase” containing regimens: Experience in Japan (2018)
  • Author(s): Yamaguchi M
  • Organizer: 2015…2018 T-Cell Lymphomas: We are close to the finalization (T-cell lymphoma forum in Bologna)
  • Int'l Joint Research / Invited
• [Presentation] NK/T細胞リンパ腫の治療：到達点と今後の展望 (2018)
  • Author(s): 山口素子
  • Organizer: 第109回近畿血液学地方会
  • Invited
• [Presentation] Incidence and risk factors of central nervous system relapse in localized extranodal NK/T-cell lymphoma, nasal type: an analysis of NKEA study (2018)
  • Author(s): Miyazaki K, Taguchi S, Oguchi M, Suzuki R, Asano N, Terui Y, Kubota N, Saito Y, Maeda T, Itasaka S, Kobayashi Y, Itami J, Amaki J, Akiba T, Murayama T, Ii N, Soejima T, Yamaguchi M, Katayama N
  • Organizer: 2018 ASH Annual Meeting
  • Int'l Joint Research
• [Presentation] Early disease progression in patients (pts) with newly diagnosed localized nasal extranodal NK/T-cell lymphoma, nasal type (ENKL) treated with radiotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC) (2017)
  • Author(s): Yamaguchi M, Suzuki R, Oguchi M, Asano N, Miyazaki K, Terui Y, Kubota N, Maeda T, Kobayashi Y, Amaki J, Soejima T, Saito B, Shimoda E, Fukuhara N, Tsukamoto N, Shimada K, Choi I, Utsumi T, Ejima Y, Katayama N, NKEA project.
  • Organizer: 2017 ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] NK/T細胞リンパ腫：新世代治療の現状と今後の展望 (2017)
  • Author(s): 山口素子
  • Organizer: 第57回日本リンパ網内系学会総会 シンポジウム
  • Invited
• [Presentation] Current and future management of NK/T-cell lymphoma (2017)
  • Author(s): Yamaguchi M
  • Organizer: 第79回日本血液学会学術集会 シンポジウム
  • Invited
• [Presentation] Improved prognosis of extranodal NK/T-cell lymphoma, nasal type (ENKL) of nasal origin but not extranasal origin: an analysis of NKEA study (2017)
  • Author(s): Yamaguchi M, Suzuki R, Miyazaki K, Amaki J, Takizawa J, Sekiguchi N, Inagaki S, Tomita N, Wada H, Kobayashi Y, Niitsu N, Ando T, Maeda T, Saito B, Matsuoka H, Sakai R, Kubota N, Masaki Y, Asano N, Oguchi M, Katayama N.
  • Organizer: 2017 ASH Annual Meeting
  • Int'l Joint Research
• [Remarks] NKEA project
  • URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000018002
• [Remarks] NKEA project
  • URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000018002&type=summary&language=J