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Optimization of new generation therapy for NK/T-cell lymphoma in East Asia

Research Project

Project/Area Number 17K09924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionMie University

Principal Investigator

Yamaguchi Motoko  三重大学, 医学部附属病院, 講師 (50359767)

Co-Investigator(Kenkyū-buntansha) 鈴木 律朗  島根大学, 学術研究院医学・看護学系, 准教授 (20280810)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsNK/T細胞リンパ腫 / 新世代治療 / 多施設共同研究 / 国際情報交換 / RT-2/3DeVIC療法 / SMILE療法 / 内科 / 東アジア / 予後予測 / 国際共同研究
Outline of Final Research Achievements

We conducted a retrospective study including patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL) diagnosed between 2000 and 2013 in 31 hospitals in Japan in part in collaborating with Korean researchers. Approximately 25% of patients with localized nasal ENKL experienced progression of disease within 24 months, regardless of treatment regimens. Most patients with extranasal ENKL did not receive new generation therapy due to impaired organ function or poor general condition. The long-term efficacy and safety of RT-DeVIC for newly-diagnosed localized nasal ENKL were confirmed with a median follow-up of 7.9 years.

Academic Significance and Societal Importance of the Research Achievements

本研究により、日本国内におけるENKL新世代治療の実態がさらに明らかにされた。早期増悪や鼻外発症など、新世代治療によっても満たされていない医療ニーズを持つ患者集団の同定は、今後の治療開発の基盤となるものである。依頼により執筆した複数の総説は国内外での治療アプローチを偏りなくレビューしており、すでに多く閲覧および引用されていることから、当初治療コンセンサスレポートの作成で意図した役割を果たしつつある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Remarks (2 results)

  • [Int'l Joint Research] Samsung Medical Center(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Samsung Medical Center(韓国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Samsung Medical Center(韓国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin2019

    • Author(s)
      Yamaguchi M, Suzuki R, Miyazaki K, Amaki J, Takizawa J, Sekiguchi N, Kinoshita S, Tomita N, Wada H, Kobayashi Y, Niitsu N, Ando T, Maeda T, Saito B, Matsuoka H, Sakai R, Kubota N, Masaki Y, Kameoka Y, Asano N, Oguchi M, Katayama N
    • Journal Title

      Annals of Hematology

      Volume: 98 Issue: 7 Pages: 1647-1655

    • DOI

      10.1007/s00277-019-03689-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type2018

    • Author(s)
      Yamaguchi M, Suzuki R, Oguchi M
    • Journal Title

      Blood

      Volume: 131 Issue: 23 Pages: 2528-2540

    • DOI

      10.1182/blood-2017-12-791418

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early disease progression in patients with localized NK/T-cell lymphoma treated with concurrent chemoradiotherapy.2018

    • Author(s)
      Yamaguchi M, Suzuki R, Kim SJ, Ko YH, Oguchi M, Asano N, Miyazaki K, Terui Y, Kubota N, Maeda T, Kobayashi Y, Amaki J, Soejima T, Saito B, Shimoda E, Fukuhara N, Tsukamoto N, Shimada K, Choi I, Utsumi T, Ejima Y, Kim WS, Katayama N.
    • Journal Title

      Cancer Sci

      Volume: - Issue: 6 Pages: 2056-2062

    • DOI

      10.1111/cas.13597

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extranodal NK/T-cell lymphoma: Updates in biology and management strategies2018

    • Author(s)
      Yamaguchi M, Oguchi M, Suzuki R
    • Journal Title

      Best Practice & Research Clinical Haematology

      Volume: 31 Issue: 3 Pages: 315-321

    • DOI

      10.1016/j.beha.2018.07.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment of NK/T-cell lymphoma: current situations and prospectives2018

    • Author(s)
      山口 素子
    • Journal Title

      Rinsho Ketsueki

      Volume: 59 Issue: 5 Pages: 588-593

    • DOI

      10.11406/rinketsu.59.588

    • NAID

      130007384584

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2018 Research-status Report
  • [Journal Article] Current treatment approaches for NK/T-cell lymphoma2017

    • Author(s)
      Yamaguchi M, Miyazaki K
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 57 Issue: 3 Pages: 98-108

    • DOI

      10.3960/jslrt.17018

    • NAID

      130006286270

    • ISSN
      1346-4280, 1880-9952
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Treatment overview of extranodal NK/T-cell lymphoma2019

    • Author(s)
      Yamaguchi M
    • Organizer
      ILROG Educational Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CLINICAL OUTCOMES AND DIAGNOSIS-TO-TREATMENT INTERVAL IN PATIENTS WITH NK/T-CELL LYMPHOMA: 7-YEAR FOLLOW-UP OF THE NKEA STUDY2019

    • Author(s)
      Yamaguchi M, Suzuki R, Oguchi M, Miyazaki K, Taguchi S, Amaki J, Maeda T, Kubota N, Maruyama D, Terui Y, Sekiguchi N, Takizawa J, Tsukamoto H, Murayama T, Ando T, Matsuoka H, Hasegawa M, Wada H, Sakai R, Kameoka Y, Tsukamoto N, Choi I, Masaki Y, Shimada K, Fukuhara N, Utsumi T, Uoshima N, Kagami Y, Asano N, Katayama N
    • Organizer
      15-ICML International Conference on Malignant Lymphoma
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Seven-year follow-up of 101 patients with advanced NK/T-cell lymphoma: NKEA study2019

    • Author(s)
      Miyazaki K, Suzuki R, Yamaguchi M, Amaki J, Sekiguchi N, Takizawa J, Ando T, Wada H, Masaki Y, Kameoka Y, Murayama T, Asano N, Oguchi M, Katayama N
    • Organizer
      The 10th JSH International Symposium 2019 in Ise-Shima
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-term outcomes and diagnosis-to-treatment interval in NK/T-cell lymphoma: 7-year follow-up of the NKEA study2019

    • Author(s)
      Miyazaki K, Yamaguchi M, Suzuki R, Oguchi M, Hasegawa M, Katayama N
    • Organizer
      第78回日本癌学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NK/T細胞リンパ腫の長期予後と 診断-治療間隔 (DTI):NKEA研究2019

    • Author(s)
      山口素子、鈴木律朗、小口正彦、宮崎香奈、田口千藏、天木惇、前田猛、久保田靖子、丸山大、照井康仁、関口和、瀧澤淳、塚本裕之、村山徹、安藤寿彦、松岡広、長谷川正俊、和田秀穂、酒井リカ、亀井吉弘、塚本憲史、崔日承、正木康史、島田和之、福原規子、内海貴彦、魚嶋伸彦、鏡味良豊、浅野直子、片山直之 (NKEA project)
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NK/T-cell lymphoma: SMILE and other “asparaginase” containing regimens: Experience in Japan2018

    • Author(s)
      Yamaguchi M
    • Organizer
      2015…2018 T-Cell Lymphomas: We are close to the finalization (T-cell lymphoma forum in Bologna)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] NK/T細胞リンパ腫の治療:到達点と今後の展望2018

    • Author(s)
      山口素子
    • Organizer
      第109回近畿血液学地方会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Incidence and risk factors of central nervous system relapse in localized extranodal NK/T-cell lymphoma, nasal type: an analysis of NKEA study2018

    • Author(s)
      Miyazaki K, Taguchi S, Oguchi M, Suzuki R, Asano N, Terui Y, Kubota N, Saito Y, Maeda T, Itasaka S, Kobayashi Y, Itami J, Amaki J, Akiba T, Murayama T, Ii N, Soejima T, Yamaguchi M, Katayama N
    • Organizer
      2018 ASH Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Early disease progression in patients (pts) with newly diagnosed localized nasal extranodal NK/T-cell lymphoma, nasal type (ENKL) treated with radiotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC)2017

    • Author(s)
      Yamaguchi M, Suzuki R, Oguchi M, Asano N, Miyazaki K, Terui Y, Kubota N, Maeda T, Kobayashi Y, Amaki J, Soejima T, Saito B, Shimoda E, Fukuhara N, Tsukamoto N, Shimada K, Choi I, Utsumi T, Ejima Y, Katayama N, NKEA project.
    • Organizer
      2017 ASCO Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] NK/T細胞リンパ腫:新世代治療の現状と今後の展望2017

    • Author(s)
      山口素子
    • Organizer
      第57回日本リンパ網内系学会総会 シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Current and future management of NK/T-cell lymphoma2017

    • Author(s)
      Yamaguchi M
    • Organizer
      第79回日本血液学会学術集会 シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Improved prognosis of extranodal NK/T-cell lymphoma, nasal type (ENKL) of nasal origin but not extranasal origin: an analysis of NKEA study2017

    • Author(s)
      Yamaguchi M, Suzuki R, Miyazaki K, Amaki J, Takizawa J, Sekiguchi N, Inagaki S, Tomita N, Wada H, Kobayashi Y, Niitsu N, Ando T, Maeda T, Saito B, Matsuoka H, Sakai R, Kubota N, Masaki Y, Asano N, Oguchi M, Katayama N.
    • Organizer
      2017 ASH Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] NKEA project

    • URL

      https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000018002

    • Related Report
      2019 Annual Research Report 2017 Research-status Report
  • [Remarks] NKEA project

    • URL

      https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000018002&type=summary&language=J

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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