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Development of novel chronic GVHD treatment based on the effects of the new therapeutic agent on helper/regulatory T cells

Research Project

Project/Area Number 17K09955
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionOkayama University

Principal Investigator

Hisakazu Nishimori  岡山大学, 大学病院, 助教 (70756064)

Co-Investigator(Kenkyū-buntansha) 前田 嘉信  岡山大学, 医歯薬学総合研究科, 教授 (60403474)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsタミバロテン / Th1細胞 / Th17細胞 / 制御性T細胞 / Th17細胞 / マウスモデル / 内科
Outline of Final Research Achievements

This study aims to control the balance of helper T cells and regulatory T cells to overcome chronic graft-versus-host disease (GVHD), a complication of allogeneic hematopoietic stem cell transplantation for hematological malignancies. We investigated what kind of cytokines and chemokines are involved based on the data obtained from the clinical trial and animal experiments on chronic GVHD.

Academic Significance and Societal Importance of the Research Achievements

慢性GVHDに関わるサイトカイン、ケモカインの動態を確認することができたため、慢性GVHD患者さんへの治療介入にあたり、これらのサイトカインを確認しながら治療することでより適切なマネジメントが可能となる。さらに、このデータを参考し、次の慢性GVHDに対する臨床試験を計画中であり、慢性GVHDに対する新たな治療開発に繋げることができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Venous Thromboembolism in Patients with Steroid-Refractory Chronic Graft-Versus-Host Disease Receiving Synthetic Retinoid Am802017

    • Author(s)
      西森久和
    • Organizer
      第59回米国血液学会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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