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Human Herpes Virus 6 reactivation after allogeneic stem cell transplantation

Research Project

Project/Area Number 17K09961
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionKeio University

Principal Investigator

YAMAZAKI Rie  慶應義塾大学, 医学部(信濃町), 助教 (80365262)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsヒトヘルペスウイルス6型 / 同種造血幹細胞移植 / CD134 / デジタル PCR / HHV-6再活性化 / デジタルPCR / ヒトヘルペスウイルス6型再活性化 / 造血幹細胞移植 / 免疫再構築 / 移植後免疫
Outline of Final Research Achievements

We prospectively evaluated the relationship between HHV-6 reactivation and CD134+ T cells inthe recipients of allo-HSCT.
HHV-6 viral load in plasma was quantitatively measured weekly after allo-HSCT by digital PCR in 34 patients. The ratio of CD134 in CD4+ T cells (CD134/CD4 ratio) was serially measured by flow cytometry before and after HSCT. The CD134/CD4 ratio before HSCT was significantly higher in patients with HHV-6 reactivation than in those without (median, 3.8% vs 1.5%, P<0.01). In the multivariate analysis, a higher CD134/CD4 ratio before conditioning (odds ratio [OR], 10.5, P=0.03) and a stem cell source from an HLA-mismatched donor (OR, 15.4, P=0.04) remained as significant factors associated with HHV-6 reactivation.

Academic Significance and Societal Importance of the Research Achievements

同種造血幹細胞移植後のHHV-6再活性化は幹細胞生着後に起こり、脳炎脊髄炎に進展した場合致死的な経過をたどることが多い。臍帯血移植がリスク因子となることが知られているが、その病態については不明な点が多い。今回の検討で、CD134陽性CD4T細胞のの移植前モニタリングによりハイリスク群を抽出できる可能性が示唆された。今後個々のリスクにあわせたウイルス量モニタリング・予防・早期治療介入を行うことで、移植後HHV-6感染症発症を減らすことができれば、移植成績の向上が期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Human Herpesvirus 6 Reactivation Evaluated by Digital Polymerase Chain Reaction and Its Association With Dynamics of CD134-Positive T Cells After Allogeneic Hematopoietic Stem Cell Transplantation2019

    • Author(s)
      Nakayama H, Yamazaki R, Kato J, Koda Y, Sakurai M, Abe R, Watanuki S, Sumiya C, Shiroshita K, Fujita S, Yamaguchi K, Okamoto S, Mori T.
    • Journal Title

      J Infect Dis

      Volume: 220(6) Issue: 6 Pages: 1001-1007

    • DOI

      10.1093/infdis/jiz237

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Introduce My Article2019

    • Author(s)
      中山瞳、山崎理絵
    • Journal Title

      Rinsho Ketsueki

      Volume: 60 Issue: 8 Pages: 1000-1001

    • DOI

      10.11406/rinketsu.60.1000

    • NAID

      130007702140

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2019 Annual Research Report
  • [Presentation] Association of CD134-positive T cells and HHV-6 reactivation evaluated by digital polymerase chain reaction in recipients of allogeneic hematopoietic stem cell transplantatiton2019

    • Author(s)
      Mori T, Nakayama H, Koda Y, Sakurai M, Abe R, Chieko S, Shiroshita K, Okamoto S, Yamazaki R
    • Organizer
      11th International Conference on HHV-6 & 7
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HHV-6 reactivation evaluated by digital polymerase chain reaction and its association with dynamics of CD134-positive T cells after allogeneic stem cell transplantation2019

    • Author(s)
      Hitomi Nakayama, Rie Yamazaki, Jun Kato, Yuya Koda, Masatoshi Sakurai, Ryohei Abe, Chieko Sumiya, Kohei Shiroshita, Shinichiro Okamoto, Takehiko Mori
    • Organizer
      45th Annual Meeting of the Europian Society for Blood and Marrow Transplantation
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 同種造血幹細胞移植後HHV-6再活性化におけるCD134陽性T細胞の影響2019

    • Author(s)
      中山 瞳、山崎 理絵、加藤 淳、甲田 祐也、櫻井 政寿、安部 涼平、綿貫 慎太郎、城下 郊平、住谷 智恵子、藤田 進也、山口 健太郎、岡本 真一郎、森 毅彦
    • Organizer
      第41回日本造血細胞移植学会総会 一般口演 大阪
    • Related Report
      2018 Research-status Report
  • [Presentation] 同種造血幹細胞移植後の HHV-6 再活性化に対する特異的液性免疫の評価.2018

    • Author(s)
      中山 瞳、山崎 理絵、加藤 淳、甲田 祐也、安部 涼平、橋田 里妙、山根 裕介、城下 郊平、佐藤 雄紀、岡本 真一郎、森 毅彦
    • Organizer
      第 40 回日本造血細胞移植学会総会 ホテル札幌芸文館(北海道)
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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