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A multitiered study for clinical subtypes, treatments, and biomarkers using inception cohorts of patients with ANCA-associated vasculitis

Research Project

Project/Area Number 17K09986
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionTokyo Women's Medical University

Principal Investigator

Tsutsumino Michi  東京女子医科大学, 医学部, 非常勤講師 (50277141)

Co-Investigator(Kenkyū-buntansha) 針谷 正祥  東京女子医科大学, 医学部, 教授 (20238207)
要 伸也  杏林大学, 医学部, 教授 (60224581)
勝又 康弘  東京女子医科大学, 医学部, 講師 (60349719)
佐田 憲映  岡山大学, 大学病院, 准教授 (70423308)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsANCA関連血管炎 / クラスター解析 / 治療戦略 / シクロホスファミド / ANCA測定法 / ANCA測定方法 / 新規臨床サブセット / 治療戦略評価 / バイオマーカー
Outline of Final Research Achievements

We obtained following results by using clinical information and samples from patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis registered in two Japanese cohort studies. We identified novel clusters of patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). We demonstrated effectiveness of treatments with cyclophosphamide (CY) in MPO-ANCA positive patients with MPA and GPA. Proportions of patients who achieved disease activity score of BVAS=0 and daily prednisolone doses of 10 mg or less were 49% and 31% in patients treated with and without CY, respectively (p=0.02). We compared several assay kits for ANCA. All methods except for a latex immune-agglutination method showed satisfactory sensitivity and specificity.

Academic Significance and Societal Importance of the Research Achievements

抗好中球細胞質抗体(ANCA)関連血管炎(AAV)は、わが国の指定難病の一つに含まれている。その希少性から診断・治療に関する研究を進めることは難しい疾患の一つである。本研究では、厚生労働省難治性血管炎研究班ですでに実施されたAAV患者コホート研究で蓄積された臨床情報と患者検体を用いて、新規臨床サブセット同定、治療戦略の検討、ANCA測定法の有用性比較を行い、新たな知見が得られた点に学術的な意義がある。ANCA測定法の有用性比較は、臨床に直結する結果を提示しており、社会的な意義が高い研究である。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2021 2020 2019 2018 Other

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (4 results) (of which Int'l Joint Research: 3 results) Remarks (2 results)

  • [Journal Article] Usefulness of tissue inhibitor of metalloproteinase 1 as a predictor of sustained remission in patients with antineutrophil cytoplasmic antibody-associated vasculitis2021

    • Author(s)
      Ishizaki J, Takemori A, Horie K, Hiraoka D, Suemori K, Matsumoto T, Sada KE, Amano K, Harigai M, Arimura Y, Makino H, Takenaka K, Takemori N, Hasegawa H, and Hirahashi J as a collaborator..
    • Journal Title

      Arthritis Research & Therapy

      Volume: 23 Issue: 1 Pages: 91-91

    • DOI

      10.1186/s13075-021-02471-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exploratory classification of clinical phenotypes in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis using cluster analysis2021

    • Author(s)
      Watanabe H, Sada KE, Harigai M, Amano K, Dobashi H, Takasaki Y, Fujimoto S, Atsumi T, Yamagata K, Homma S, Arimura Y, Makino H
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-84627-6

    • NAID

      120007027577

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] JCS 2017 Guideline on Management of Vasculitis Syndrome ― Digest Version ―2020

    • Author(s)
      Isobe, M. Amano, K. Arimura, Y. Ishizu, A. Ito, S. Kaname, S. Takahashi, K. Tanemoto, K. Hasegawa, H. Harigai, M. Fujimoto, S. Miyazaki, T. et.al.
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 2 Pages: 299-359

    • DOI

      10.1253/circj.CJ-19-0773

    • NAID

      130007789906

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2020-01-24
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis2020

    • Author(s)
      Yokoe Y、Tsuboi N、Imaizumi T、Kitagawa A、Karasawa M、Ozeki T、Endo N、Sawa Y、Kato S、Katsuno T、Maruyama S、Yamagata K、Usui J、Nagata M、Sada K、Sugiyama H、Amano K、Arimura Y、Atsumi T、Yuzawa Y、Dobashi H、Takasaki Y、Harigai M、Hasegawa H、Makino H、Matsuo S
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: in press Issue: 8 Pages: 1-12

    • DOI

      10.1093/ndt/gfaa097

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment-related damage in elderly-onset ANCA-associated vasculitis: safety outcome analysis of two nationwide prospective cohort studies2020

    • Author(s)
      Sada KE, Ohashi K, Asano Y, Hayashi K, Morishita M, Watanabe H, Matsumoto Y, Fujimoto S, Takasaki Y, Yamagata K, Banno S, Dobashi H, Amano K, Harigai M, Arimura Y, Makino H and Hirahashi J as a collaborator.
    • Journal Title

      Arthritis Research & Therapy

      Volume: 22 Issue: 1

    • DOI

      10.1186/s13075-020-02341-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study2020

    • Author(s)
      Fukui S、Ichinose K、Sada K-E、Miyamoto J、Harigai M、Amano K、Atsumi T、Takasaki Y、Dobashi H、Arimura Y、Hasegawa H、Yuzawa Y、Yamagata K、Tsuboi N、Maruyama S、Matsuo S、Makino H、Maeda T、Kawakami A
    • Journal Title

      Scandinavian Journal of Rheumatology

      Volume: 49 Issue: 4 Pages: 301-311

    • DOI

      10.1080/03009742.2019.1695927

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of TERT and DSP variants with microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis in a Japanese population: a genetic association study2020

    • Author(s)
      Kawasaki Aya、Namba Natsumi、Sada Ken-ei、Hirano Fumio、Kobayashi Shigeto、Nagasaka Kenji、Sugihara Takahiko、Ono Nobuyuki、Fujimoto Takashi、Kusaoi Makio、Tamura Naoto、Yamagata Kunihiro、Sumida Takayuki、Hashimoto Hiroshi、Ozaki Shoichi、Makino Hirofumi、Arimura Yoshihiro、Harigai Masayoshi、Tsuchiya Naoyuki
    • Journal Title

      Arthritis Research & Therapy

      Volume: 22 Issue: 1

    • DOI

      10.1186/s13075-020-02347-0

    • NAID

      120007188741

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rationale of concomitant cyclophosphamide for remission-induction in patients with antineutrophil cytoplasmic antibody-associated vasculitis: A propensity score-matched analysis of two nationwide prospective cohort studies.2020

    • Author(s)
      Watanabe H
    • Journal Title

      Mod Rheumatol.

      Volume: 6 Issue: 1 Pages: 1-9

    • DOI

      10.1080/14397595.2019.1707997

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Optimal initial dose of glucocorticoid for elderly-onset ANCA associated vasculitis: safety outcome analysis of two nationwide, prospective, inception cohort studies.2019

    • Author(s)
      Keiji Ohashi
    • Organizer
      EULAR 2019. Jun,12-15; Madrid, Spain.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effectiveness of remission-induction therapy with concomitant cyclophosphamide and glucocorticoid for microscopic polyangiitis and granulomatosis with polyangiitis in Japan: a propensity score matched analysis of two nationwide prospective cohort studies2018

    • Author(s)
      Haruki Watanabe
    • Organizer
      第19回欧州リウマチ学会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effectiveness of remission-induction therapy with concomitant Cyclophosphamide and glucocorticoid for patients with microscopic polyangiitis and granulomatosis with polyangiitis in Japan2018

    • Author(s)
      Haruki Watanabe
    • Organizer
      第20回アジア太平洋リウマチ学会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] クラスター解析を用いたANCA関連血管炎の分類と重症度に関する検討2018

    • Author(s)
      佐田 憲映
    • Organizer
      第62回日本リウマチ学会
    • Related Report
      2018 Research-status Report
  • [Remarks] 東京女子医科大学 膠原病リウマチ痛風センター

    • URL

      http://www.twmu.ac.jp/IOR/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 難治性血管炎の医療水準・患者QOL向上に資する研究班

    • URL

      https://www.vas-mhlw.org/

    • Related Report
      2020 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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