cluster analysis

• Project/Area Number: 17K09990
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Nippon Medical School
• Principal Investigator: Takeno Mitruhito 日本医科大学, 医学部, 准教授 (50236494)
• Co-Investigator(Kenkyū-buntansha): 桐野 洋平 横浜市立大学, 医学部, 講師 (50468154) ; 黒沢 美智子 順天堂大学, 医学部, 准教授 (70245702) ; 水木 信久 横浜市立大学, 医学研究科, 教授 (90336579)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ベーチェット病 / HLA / クラスター解析 / 腸管ベーチェット病 / クラスター分類 / 腸管型 / HLA-B51 / HLA-B26 / 腸管症状 / 遺伝素因 / 環境因子 / 年齢 / 性差 / フェノタイプ / ゲノタイプ

Outline of Final Research Achievements

We hypothesized that patients with Behcet’s disease (BD) are categorized into several clinical phenotypes based on clinical presentations. Cluster analysis in our cohort with 657 cases and 7399 registry forms of specific disease treatment, Ministry of Health, Labour, and Welfare, identified an intestinal variant cluster which was distinct from classical forms of BD having mucocutaneous, ocular, and neurological involvement. Patients in the intestinal cluster often more commonly required TNF inhibitors and more frequent hospitalization than other clusters. Presence of arthritis, absence of eye lesions, and negative for HLA-B51 were identified as predisposing factors to the cluster. Early clustering based on clinical presentations and genetic factors may contribute to personalized preemptive medicine.

Academic Significance and Societal Importance of the Research Achievements

ベーチェット病の臨床像は多様であり、病型、重症度に応じた治療対応が必要であり、国内外の診療ガイドラインにおいても個別化医療の重要性が強調されている。本研究の臨床亜群分類の試みは、今後、亜群ごとの臨床経過、予後、治療反応性を明らかにすることで将来的な個別化医療の礎となるものと期待される。また、HLA-B51の有無がそれぞれ眼病変、腸管病変と関連するなど、遺伝素因の関与について明らかにすることで、より早期の亜群分類が可能となり、個別化された先制医療にもつながるものと期待される。

Research Products

• [Journal Article] JCS 2017 Guideline on Management of Vasculitis Syndrome ― Digest Version ― (2020)
  • Author(s): Isobe, M. Amano, K. Arimura, Y. Ishizu, A. Ito, S. Kaname, S. Takahashi, K. Tanemoto, K. Hasegawa, H. Harigai, M. Fujimoto, S. Miyazaki, T. et.al.
  • Journal Title: Circulation Journal Volume: 84 Issue: 2 Pages: 299-359
  • DOI: 10.1253/circj.CJ-19-0773
  • NAID: 130007789906
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-01-24
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HLA-A26 is a risk factor for Behcet’s disease ocular lesions (2020)
  • Author(s): Kato H, Takeuchi M, Horita N, Ishido T, Mizuki R, Kawagoe T, Shibuya E, Yuda K, Ishido M, Mizuki Y, Hayashi T, Meguro A, Kirino Y, Minegishi K, Nakano H, Yoshimi R, Kurosawa M, Fukumoto T, Takeno M, Hotta K, Kaneko T, Mizuki N
  • Journal Title: Modern Rheumatology Volume: 30 Issue: 1 Pages: 1-5
  • DOI: 10.1080/14397595.2019.1705538
  • Peer Reviewed / Open Access
• [Journal Article] 小児ベーチェット病 vs 成人ベーチェット病 特集〈Clinical Science〉免疫難病における小児から成人へのtransitionの課題と対策 (2020)
  • Author(s): 岳野光洋
  • Journal Title: 炎症と免疫 Volume: 28(1) Pages: 56-61
• [Journal Article] Positioning of apremilast in treatment of Behcet’s disease (2019)
  • Author(s): Takeno Mitsuhiro
  • Journal Title: Modern Rheumatology Volume: 30 Issue: 2 Pages: 219-224
  • DOI: 10.1080/14397595.2019.1696504
  • Peer Reviewed / Open Access
• [Journal Article] Trial of Apremilast for Oral Ulcers in Behcet’s Syndrome (2019)
  • Author(s): Hatemi Gulen、Mahr Alfred、Ishigatsubo Yoshiaki、Song Yeong-Wook、Takeno Mitsuhiro、Kim Doyoung、Meliko?lu Melike、Cheng Sue、McCue Shannon、Paris Maria、Chen Mindy、Yazici Yusuf
  • Journal Title: New England Journal of Medicine Volume: 381 Issue: 20 Pages: 1918-1928
  • DOI: 10.1056/nejmoa1816594
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The influence of HLA-B51 on clinical manifestations among Japanese patients with Beh?et’s disease: A nationwide survey (2019)
  • Author(s): Mizuki Y, Horita N, Horie Y, Takeuchi M, Ishido T, Mizuki R, Kawagoe T, Shibuya E, Yuda K, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Kurosawa M, Kitaichi N, Takeno M, Kaneko T, Mizuki N.
  • Journal Title: Modern Rheumatology Volume: 6 Issue: 4 Pages: 1-7
  • DOI: 10.1080/14397595.2019.1649103
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of early-stage possible Behcet's disease patients with a variant-type major organ involvement in Japan (2019)
  • Author(s): Suzuki T, Horita N, Takeuchi M, Ishido T, Mizuki Y, Mizuki R, Kawagoe T, Shibuya E, Yuta K, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Ishigatsubo Y, Kurosawa M, Takeno M, Kaneko T, Mizuki N
  • Journal Title: Mod Rheumatol Volume: 30 Issue: 4 Pages: 1-7
  • DOI: 10.1080/14397595.2018.1494501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ベーチェット病. 膠原病診療 update -診断・治療の最新知見- (2019)
  • Author(s): 岳野光洋
  • Journal Title: 日本臨床 Volume: 77(3) Pages: 558-565
• [Journal Article] 2018改訂ベーチェット症候群の診療に関するEULAR推奨(話題). (2019)
  • Author(s): 岳野光洋
  • Journal Title: リウマチ科 Volume: 61(6) Pages: 582-588
• [Journal Article] 【知らなきゃ手古摺る乾癬治療!アプレミラスト200%活用術!】(Part1)アプレミラストの基礎を学ぶ!(総説3) Behcet病に対するアプレミラスト治療(解説/特集) (2019)
  • Author(s): 岳野光洋
  • Journal Title: Visual Dermatology Volume: 10(10) Pages: 998-999
• [Journal Article] ベーチェット病. 膠原病診療 update -診断・治療の最新知見 (2019)
  • Author(s): 岳野光洋
  • Journal Title: 日本臨床 Volume: 77 Pages: 558-565
• [Journal Article] 突然出現した左頸部の拍動性腫瘤 診断力を上げる！症例問題集 (2019)
  • Author(s): 岳野光洋、桑名正隆
  • Journal Title: 内科 臨床雑誌 Volume: 123 Pages: 827-828
• [Journal Article] 2018改訂ベーチェット症候群の診療に関するEULAR推奨(話題) (2019)
  • Author(s): 岳野光洋
  • Journal Title: リウマチ科 Volume: 61
• [Journal Article] GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behcet's disease (2018)
  • Author(s): Nakano H, Kirino Y, Takeno M, Higashitani K, Nagai H, Yoshimi R, Yamaguchi Y, Kato I, Aoki I, Nakajima H
  • Journal Title: Arthritis Res Ther. Volume: 20 Issue: 1 Pages: 124-124
  • DOI: 10.1186/s13075-018-1613-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Behçet's disease (2018)
  • Author(s): Suwa A, Horita N, Ishido T, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Ishigatsubo Y, Kurosawa M, Kaneko T, Takeno M, Mizuki N
  • Journal Title: Modern Rheumatology Volume: 27 Issue: 2 Pages: 1-17
  • DOI: 10.1080/14397595.2018.1457424
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 血管型ベーチェット病 血管型ベーチェット病 (2018)
  • Author(s): 岳野光洋
  • Journal Title: 日本臨床 Volume: 増刊 Pages: 413-417
• [Journal Article] 日本人のベーチェット病の疫学：疫学から病因へ (2018)
  • Author(s): 岳野光洋
  • Journal Title: リウマチ科 Volume: 60 Pages: 332-339
• [Journal Article] Behcet'病の免疫病態-自己炎症とMHC-I-opathy. (2018)
  • Author(s): 岳野光洋
  • Journal Title: 医学のあゆみ Volume: 267 Pages: 728-733
• [Journal Article] Distinct clinical features between acute and chronic progressive parenchymal neuro-Behcet disease: meta-analysis. (2017)
  • Author(s): Ishido M, Horita N, Takeuchi M, Shibuya E, Yamane T, Kawagoe T, Ishido T, Minegishi K, Yoshimi R, Kirino Y, Hirohata S, Ishigatsubo Y, Takeno M, Kaneko T, Mizuki N
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 10196-10196
  • DOI: 10.1038/s41598-017-09938-z
  • Peer Reviewed / Open Access
• [Journal Article] Clinical manifestations of Behcet 's disease depending on sex and age: results from Japanese nationwide registration (2017)
  • Author(s): Ishido T, Horita N, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Ishigatsubo Y, Takeno M, Kurosawa M, Kaneko T, Mizuki N.
  • Journal Title: Rheumatology (Oxford). Volume: 56 Pages: 1918-1927
  • Peer Reviewed
• [Journal Article] ベーチェット病の神経病変 (2017)
  • Author(s): 岳野光洋
  • Journal Title: リウマチ科 Volume: 57 Pages: 473-480
• [Journal Article] ベーチェット病の中枢神経病変 (2017)
  • Author(s): 岳野光洋
  • Journal Title: リウマチ科 Volume: 58 Pages: 33-39
• [Journal Article] ベーチェット病遺伝素因 (2017)
  • Author(s): 岳野光洋
  • Journal Title: リウマチ科 Volume: 58 Pages: 412-419
• [Journal Article] 血管型ベーチェット病 (2017)
  • Author(s): 岳野光洋
  • Journal Title: 医学のあゆみ Volume: 263 Pages: 521-524
• [Presentation] Efficacy of Apremilast for Oral Ulcers Associated With Active Behçet’s Syndrome Over 64 Weeks: Long-term Results From the Japanese Subgroup in a Phase III Study. (2019)
  • Author(s): Takeno M, Tanaka Y, Kono H, Sugii S, Kishimoto M, Cheng S, McCue S, Chen M, Paris M, Dobashi H.
  • Organizer: 2019 ACR/ARHP Annual Meeting (Atlanta)
  • Int'l Joint Research
• [Presentation] ベーチェット病治療戦略における口腔内病変の位置づけ(ランチョンセミナー). (2019)
  • Author(s): 岳野光洋.
  • Organizer: 第3回日本ベーチェット病学会、横
  • Invited
• [Presentation] ベーチェット病に対するApremilast治療 (ランチョンセミナー). (2019)
  • Author(s): 岳野光洋.
  • Organizer: 第29回 日本リウマチ学会北海道東北支部学術集会、青森
  • Invited
• [Presentation] Meet the Expert ベーチェット病 (2019)
  • Author(s): 岳野光洋.
  • Organizer: 第63回日本リウマチ学会総会・学術集会. (京都).
  • Invited
• [Presentation] .ベーチェット病の病態（イーブニングセミナー） (2019)
  • Author(s): 岳野光洋
  • Organizer: 第63回日本リウマチ学会総会・学術集会. (京都).
  • Invited
• [Presentation] ベーチェット病の診療ガイドライン. (シンポジウム14 リウマチ性疾患のガイドライン). (2019)
  • Author(s): 岳野光洋
  • Organizer: 第63回日本リウマチ学会総会・学術集会. (京都).
  • Invited
• [Presentation] ベーチェット病の臨床亜群: 臨床個人調査表2218症例の解析から (2019)
  • Author(s): 岳野光洋、黒沢美智子、副島裕太郎、桐野洋平
  • Organizer: 第63回日本リウマチ学会総会・学術集会. (京都).
• [Presentation] Improvements and Correlations in Oral Ulcers, Disease Activity, and Quality of Life in Behcet’s Syndrome: A Phase III Randomized, Double-Blind, Placebo-Controlled Study (RELIEF) (2019)
  • Author(s): Hatemi G, Mahr A, Takeno M, Kim DY, Melikoglu M, Cheng S, McCue S, Paris M, Chen M, Yazici Y.
  • Organizer: American Academy of Dermatology Annual Meeting AAD （Wahsihngon DC）
  • Int'l Joint Research
• [Presentation] ベーチェット病患者のサブグループ化と個別改良に向けての展望. (2018)
  • Author(s): 副島裕太郎、桐野洋平、岳野光洋 他
  • Organizer: 第62回日本リウマチ学会総会・学術集会
• [Presentation] 性別、発症年齢とベーチェット病の臨床像：臨床調査個人票を用いた解析. (2018)
  • Author(s): 岳野光洋、堀田信之、桐野洋平
  • Organizer: 第62回日本リウマチ学会総会・学術集会
• [Presentation] インフリキシマブ投与中に正常な妊娠と分娩を遂行できた難治性ベーチェット病の一例. (2018)
  • Author(s): 由井智子、岳野光洋、大内望、堀純子
  • Organizer: 第122回日本眼科学会総会
• [Presentation] ベーチェット病の診断と治療. (Meet the Expert 18) (2018)
  • Author(s): 岳野光洋
  • Organizer: 第62回日本リウマチ学会
  • Invited
• [Presentation] ベーチェット病のトータルマネーメント 特殊病型の治療 (2018)
  • Author(s): 岳野光洋
  • Organizer: フォーサム（第55回日本眼感染症学会 第52回日本眼炎症学会 第61回日本コンタクトレンズ学会総会 第7回日本涙道・涙液学会総会）
  • Invited
• [Presentation] 血管型ベーチェット病 エビデンスに基づいた診療ガイドライン（ランチョンセミナー） (2018)
  • Author(s): 岳野光洋
  • Organizer: 第2回日本ベーチェット病学会
  • Invited
• [Presentation] Apremilast for Beh&cet’s Syndrome: Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study in a Japanese Subgroup. (2018)
  • Author(s): Takeno M , Tanaka Y, Knon H, Sugii M, Kishimoto M, Chen S, McCue S, Paris M, Dobasshi H.
  • Organizer: 2018 ACR/ARHP Annual Meeting (Chicago）
  • Int'l Joint Research
• [Presentation] Efficacy of Apremilast for Oral Ulcers Associated with Active Behcet’s Syndrome in a Phase III Study: A Prespecified Analysis By Baseline Patient Demographics and Disease Characteristics. (2018)
  • Author(s): Hatemi G, Mahr A, Takeno M, Kim DY, Melikoglu M, Cheng S, McCue S, Paris M, Chen M, Yazici Y.
  • Organizer: 2018 ACR/ARHP Annual Meeting (Chicago),
  • Int'l Joint Research
• [Presentation] Subgroup classification of Behcet’s disease using clinical information: analysis of a clinical database of patients receiving financial aid for treatment. (2018)
  • Author(s): Kurosawa M, Takeno M, Kirino Y, Soejima N, Mizuki N:
  • Organizer: 18th International Conference on Behcet’s Disease (Rotterdam, Netherland)
  • Int'l Joint Research
• [Presentation] Clustering analysis of Japanese Behcet’s disease identifies intestinal type as distinct cluster. (2018)
  • Author(s): Soejima N, Kirino Y, Takeno M, Yoshimi R, Kurosawa M, Takeuchi M, Megro A, Mizuki N, Nakajima H.
  • Organizer: 18th International Conference on Behcet’s Disease (Rotterdam, Netherland)
  • Int'l Joint Research
• [Presentation] nfluence of sex and age on clinical manifestations of Behcet’s disease: data of 6627 patients from Japanses nationwide survey database. (2018)
  • Author(s): Takeno M, Ishido T, Horita N, Kirino Y, Kurosawa M, Mizuki N.
  • Organizer: 18th International Conference on Behcet’s Disease (Rotterdam, Netherland)
  • Int'l Joint Research
• [Presentation] Apremilast for oral ulcers in Behcet’s Syndrome: a phase III randomized, double blind,placebo-controlled study (RELIEF) (2018)
  • Author(s): Hatemi G, Mahr A, Takeno M , Kim DY, Melikoglu M, Cheng S, McCue S, Paris M, Chen M, Yazici Y.
  • Organizer: 18th International Conference on Behcet’s Disease (Rotterdam, Netherland)
  • Int'l Joint Research
• [Presentation] Apremilast for Behcet’s Syndrome: Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study in a Japanese Subgroup. (2018)
  • Author(s): Kono H, Dobasshi H, Tanaka Y, Sugii M, Kishimoto M, Chen S, McCue S, Paris M, Takeno M.
  • Organizer: 18th International Conference on Behcet’s Disease (Rotterdam, Netherland)
  • Int'l Joint Research
• [Presentation] Apremilast for Behcet’s Syndrome: A Phase III Randomized, Placebo-Controlled, Double-Blind Study (RELIEF). (2018)
  • Author(s): Hatemi G, Mahr A, Takeno M, Kim DY, Melikoglu M, Cheng S, McCue S, Paris M, Yazici Y:
  • Organizer: Annual European Congress of Rheumatology EULAR 2018 (Amsterdam, Netherlands)
  • Int'l Joint Research
• [Presentation] Apremilast for Behcet’s Syndrome: A Phase III Randomized, Placebo-Controlled, Double-Blind Study. (2018)
  • Author(s): Hatemi G, Mahr A, Takeno M, Kim DY, Melikoglu M, Cheng S, McCue S, Paris M, Yazici Y
  • Organizer: American Academy of Dermatology Annual Meeting AAD 2018 (San Diego, CA)
  • Int'l Joint Research
• [Presentation] Recommendations for the Management of Neuro-Behcet’s Disease By the Japanese National Research Committee for Behcet’s Disease. (2017)
  • Author(s): Kikuchi H, Sawada T, Okada M, Takeno M, Kuwana M, Ishigatsubo Y, Kawachi I, Mochizuki H, Kusunoki S and Hirohata S
  • Organizer: 2017 ACR/ARHP Annual Meeting (San Diego)
• [Presentation] Ocular Involvement Is Exclusive with Genital Ulcer and Skin Lesion in the Early Phase of Behcet’s Disease: Nationwide Japanese Registration. (2017)
  • Author(s): Horita N, Suwa A, Takeno M, Ishido T, Kirino Y and Mizuki N:
  • Organizer: 2017 ACR/ARHP Annual Meeting (San Diego)
• [Presentation] Clinical Manifestations of Behcet’s Disease Depending on Sex and Age: Nationwide Japanese Registration. (2017)
  • Author(s): Ishido T, Horita N , Takeno M, Ishido M, Kirino Y and Mizuki N
  • Organizer: 2017 ACR/ARHP Annual Meeting (San Diego)
• [Presentation] Draft of recommendations for the management of vasculo-Behcet’s disease in Japan. (2017)
  • Author(s): Takeno M, Nagafuchi H, Ishibashi H, Ogino H, Maeda H, Kikuchi H, Ishigatsubo Y:
  • Organizer: The 8th Japan-Korean Joint Meeting on Behcet’s Disease. (Yokohama)
  • Invited
• [Presentation] Beyond genome-wide association study of Behet’s disease. (2017)
  • Author(s): Kirino Y, Nakano H, Soejima Y, Takeno M, Takeuchi M, Meguro A, Mizuki N, Nakajima H:
  • Organizer: The 8th Japan-Korean Joint Meeting on Behcet's Disease. (Yokohama)
  • Invited
• [Presentation] Recommendations for the Management of Neuro-Behcet’s Disease By the Japanese National Research Committee for Behcet’s Disease. (2017)
  • Author(s): Kikuchi H, Sawada T, Okada M, Takeno M, Kuwana M, Ishigatsubo Y, Kawachi I, Mochizuki H, Kusunoki S and Hirohata S
  • Organizer: The 8th Japan-Korean Joint Meeting on Behcet's Disease. (Yokohama)
  • Invited
• [Presentation] ベーチェット病とtoll様受容体 (2017)
  • Author(s): 岳野光洋
  • Organizer: 日本眼科学会総会 (東京)
  • Invited
• [Presentation] ベーチェット病患者のサブグループ化と個別改良に向けての展望. (2017)
  • Author(s): 副島裕太郎、桐野洋平、岳野光洋、出口治子、須田昭子、杉山裕美子、土田奈緒美、國下洋輔、神山玲光、渡邉俊幸、上原武晃、峯岸薫、浜真麻、吉見竜介、山崎哲、浅見由希子、関口章子、井畑淳、大野滋、上田敦久、五十嵐俊久、長岡昇平、石ヶ坪良明、中島秀明
  • Organizer: 第61回日本リウマチ学会総会・学術集会 (福岡)
• [Presentation] 神経ベーチェット病の診療のガイドライン改訂に向けて (2017)
  • Author(s): 菊池弘敏、沢田哲治、岡田正人、岳野光洋、桑名正隆、石ヶ坪良明、廣畑俊成
  • Organizer: 第61回日本リウマチ学会総会・学術集会 (福岡)
• [Presentation] ベーチェット病深部静脈血栓症に対する抗凝固療法 (2017)
  • Author(s): 岳野光洋、出口治子、桑名正隆、菊池弘敏、永渕裕子、廣畑俊成、石ヶ坪良明
  • Organizer: 第61回日本リウマチ学会総会・学術集会. (福岡).
• [Presentation] 広範な下大静脈血栓症にて診断された血管Behcet病の一例 (2017)
  • Author(s): 秀川賀春、月山秀明、小宮孝章、小林幸司、峯岸薫、岳野光洋、大野滋、中島秀明
  • Organizer: 第61回日本リウマチ学会総会・学術集会. (福岡).
• [Book] 医学のあゆみ（別冊）自己炎症性疾患―病態解明から診療体制の確立まで (2019)
  • Author(s): 岳野光洋 （西小森隆太編）
  • Total Pages: 94
  • Publisher: 医歯薬出版
• [Book] ベーチェット病診療ガイドライン2020 (2019)
  • Author(s): 日本ベーチェット病学会
  • Total Pages: 200
  • Publisher: 診断と治療社
  • ISBN: 9784787824042
• [Book] イヤーノートTopics 2018-2019 (2018)
  • Author(s): 岳野光洋 他 岡庭豊編
  • Total Pages: 3
  • Publisher: メディックメディア
• [Book] 病気がみえる vol.6 免疫・膠原病・感染症（第2版 (2018)
  • Author(s): 岳野光洋 他
  • Total Pages: 4
  • Publisher: メディックメディア
• [Book] 先端医学社 (2018)
  • Author(s): 岳野光洋、桐野洋平、桑名正隆 他 鈴木康夫編
  • Total Pages: 25
  • Publisher: 腸管ベーチェット病のすべてがわかる- 診療ハンドブック
• [Book] イヤーノート 2019 (2018)
  • Author(s): 岳野光洋 （岡庭豊編）
  • Total Pages: 3648
  • Publisher: メディックメディア
  • ISBN: 4896326768
• [Remarks] ベーチェット病 血管炎症候群の診療ガイドライン（2017年改訂版）礒部光章 編
  • URL: http://www.j-circ.or.jp/guideline/pdf/JCS2017_isobe_h.pdf