| Project/Area Number |
17K09999
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Kanazawa Medical University (2019-2022)
Kanazawa University (2017-2018) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
塚 正彦 金沢大学, 医学系, 教授 (00272956)
伊藤 清亮 金沢大学, 附属病院, 医員 (10467110)
川野 充弘 金沢大学, 附属病院, 講師 (20361983)
水島 伊知郎 金沢大学, 附属病院, 助教 (50645124)
原 怜史 金沢大学, 医学系, 助教 (80749820)
|
|---|
| Project Period (FY) |
2017-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | IgG4関連疾患 / 自然免疫 / Toll-like receptor-9 / Galectin-3 / ガレクチン３ / Toll-like receptor |
|---|
| Outline of Final Research Achievements |
In salivary gland tissues from patients with IgG4-related diseases, galectin-3, produced by M2 macrophages, is expressed at inflammation sites. It was confirmed that TLR-9 expression coincided with sites of inflammation in the kidneys of LAT Y136F knock-in mice. Thereafter, CpG oligodeoxynucleotides (CpG-ODN), a TLR-9 agonist, were administered to the mice to determine if the lesions could be alleviated by shifting the immune response to a Th1 response. The results demonstrated that administration of CpG-ODN from the age of 6 weeks suppressed the progression of lung lesions. However, when CpG-ODN was administered from the age of 9 weeks, the formation of granulomas was observed.
|
| Academic Significance and Societal Importance of the Research Achievements |
IgG4関連疾患における自然免疫の関与については、これまでも報告されているが、今回Gal-3やTLR-9もIgG4関連疾患の病態形成に何らの影響を与えている可能性が示唆された。今後、新規薬剤のターゲットの候補分子としての基礎となるデータを得た点が学術的意義があると考える。
|
