Analysis of the relationship between the pathology of rheumatoid arthritis and the intestinal flora.
| Project/Area Number |
17K10002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Osaka University |
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Principal Investigator |
Narazaki Masashi 大阪大学, 医学系研究科, 特任教授(常勤) (00467573)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 関節リウマチ / 腸内細菌叢 / 炎症 / メタボローム / 免疫疾患 / 腸内細菌 |
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| Outline of Final Research Achievements |
Changes in the intestinal flora and metabolites caused by the intestinal bacteria have various effects on the human body. In collaboration with Dr. Okada Y and others on campus, a whole-genome shotgun sequence analysis of the intestinal flora revealed that patients with rheumatoid arthritis are rich in multiple species belonging to the genus Prevotella, such as Prevotella denticola, in addition to P. copri. The genes related to the redox reaction were significantly reduced in patients with rheumatoid arthritis. In addition, serum metabolome analysis showed that the concentrations of nucleic acids such as UTP, ATP, GDP, and ADP were high and decreased after treatment, and these nucleic acids were disease-specific metabolites in patients with rheumatoid arthritis.
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| Academic Significance and Societal Importance of the Research Achievements |
関節リウマチは免疫異常と慢性関節炎を特徴とし、関節機能障害に至る免疫疾患である。生物製剤の普及により予後は改善されてきたが、疾患の根本的原因は不明である。研究代表者らは過去に関節リウマチ患者から得られた腸内細菌P. copri菌をマウスへ投与すると関節炎が誘導されることを示した。本研究ではP. copri以外にもPrevotella属に属する複数の菌種が豊富に存在することを報告し、これらの菌株も関節リウマチの病態形成要因である可能性が示唆された。関節リウマチ血清では核酸濃度変化を指摘し、これまで臨床現場で測定されている炎症マーカー以外の新規疾患フォローマーカーとなる可能性がある。
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population2020
Author(s)
Kishikawa T, Maeda Y, Nii T, Motooka D, Matsumoto Y, Matsushita M, Matsuoka H, Yoshimura M, Kawada S, Teshigawara S, Oguro E, Okita Y, Kawamoto K, Higa S, Hirano T, Narazaki M, Ogata A, Saeki Y, Nakamura S, Inohara H, Kumanogoh A, Takeda K, Okada Y.
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Journal Title
Annals of the Rheumatic Diseases
Volume: 79(1)
Issue: 1
Pages: 103-111
DOI
Related Report
Peer Reviewed / Open Access
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