| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
In this study, we identified a disease susceptibility gene (group) against Streptococcus pneumoniae and analyzed its role and function. Comparative genomic analysis identified the susceptible gene group, which included the chemokine receptor CXCR2. The expression of Cxcl1 and Cxcl2 in the lungs was measured. Analysis of neutrophils and macrophages in mice with severe lung inflammation showed delayed recruitment of neutrophils and macrophages to the lungs in correlation with the gene expression results. It was suggested that the delayed response to pathogens in the early stages of infection is related to the severity of pneumonia.
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