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Characterization of Aspergillus derived extracellular vesicles and application to a diagnostics

Research Project

Project/Area Number 17K10040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Miyazaki Yoshitsugu  国立感染症研究所, 真菌部, 部長 (00311861)

Co-Investigator(Kenkyū-buntansha) 山越 智  国立感染症研究所, 真菌部, 室長 (00212283)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords分泌小胞 / RNA / 膜タンパク質 / ガラクトマンナン / アスペルギルス / 病原性真菌診断系
Outline of Final Research Achievements

The research object is to develop a new diagnostic method for invasive aspergillosis by detecting extracellular vesicles (EVs) on the basis of our presumption that EVs of Aspergillus fumigatus are secreted into blood and urine. We have analyzed proteins and RNAs in EVs prepared by ultracentrifugation. Finally, we have constructed detection systems of RNA by RT-PCR, but not reached to establish a concentration method of EVs by an antibody against membrane proteins of EVs.

Academic Significance and Societal Importance of the Research Achievements

本研究においてアスペルギルス症の主な原因菌であるAspergillus fumigatusでも他の真菌と同様に分泌小胞が確認され、さらにRNAの解析より様々な小分子RNAが同定された。人をはじめとする高等生物の分泌小胞の1つであるエクソソームでは、含まれる小分子RNAの種類が病気を反映すること、また、それがエクソソームを介して他の細胞に伝達され病気に関係することが分かってきており、アスペルギルス症においても、真菌の分泌小胞のRNAが、病態を反映するだけでなく病原性にも関与することも考えられ、本研究で得られた成果は、今後の真菌症の基礎および臨床研究に寄与するものと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (46 results)

All 2020 2019 2018 2017

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 9 results) Presentation (27 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] Selection of Oral Antifungals for Initial Maintenance Therapy in Chronic Pulmonary Aspergillosis: A Longitudinal Analysis.2020

    • Author(s)
      Masato Tashiro,Takahiro Takazono,Tomomi Saijo,Kazuko Yamamoto,Yoshifumi Imamura,Taiga Miyazaki,Hiroshi Kakeya,Tsunehiro Ando,Kenji Ogawa,Kazuma Kishi,Issei Tokimatsu,Yuta Hayashi,Satoru Fujiuchi,Katsunori Yanagihara,Yoshitsugu Miyazaki,Kiyoshi Ichihara,Hiroshi Mukae,Shigeru Kohno,Koichi Izumikawa]
    • Journal Title

      Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

      Volume: 70 Issue: 5 Pages: 835-842

    • DOI

      10.1093/cid/ciz287

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Echinocandins versus non-echinocandins for empirical antifungal therapy in patients with hematological disease with febrile neutropenia: A systematic review and meta-analysis.2020

    • Author(s)
      Chizuru Yamashita,Yoshio Takesue,Kazuaki Matsumoto,Kazuhiro Ikegame,Yuki Enoki,Motoi Uchino,Taiga Miyazaki,Koichi Izumikawa,Tohru Takada,Keiji Okinaka,Takashi Ueda,Yoshitsugu Miyazaki,Toshihiko Mayumi]
    • Journal Title

      Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

      Volume: 26 Issue: 6 Pages: 596-603

    • DOI

      10.1016/j.jiac.2020.01.015

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic Nodular Pulmonary Aspergillosis in a Patient with Rheumatoid Arthritis2019

    • Author(s)
      Yuhei Ito,Motoaki Tanigawa,Tamiko Takemura,Keisuke Iwamoto,Akina Nigi,Hajime Sasano,Hidetoshi Itani,Shigeto Kondo,Toshiya Tokui,Shigeki Nakamura,Yoshitsugu Miyazaki]
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 7 Pages: 979-984

    • DOI

      10.2169/internalmedicine.1918-18

    • NAID

      130007622191

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-04-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a Novel Variant Form of <i>Aspergillus fumigatus</i> CalC and Generation of Anti-CalC Monoclonal Antibodies2019

    • Author(s)
      Takatsuka Shogo、Inukai Tatsuya、Kawakubo Shun、Umeyama Takashi、Abe Masahiro、Ueno Keigo、Hoshino Yasutaka、Kinjo Yuki、Miyazaki Yoshitsugu、Yamagoe Satoshi
    • Journal Title

      Medical Mycology Journal

      Volume: 60 Issue: 1 Pages: 11-16

    • DOI

      10.3314/mmj.18-00013

    • NAID

      130007605409

    • ISSN
      2185-6486, 2186-165X
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient2019

    • Author(s)
      Kobayashi Keigo、Asakura Takanori、Kawada Ichiro、Hasegawa Hanako、Chubachi Shotaro、Ohara Kentaro、Kuramoto Junko、Sugiura Hiroaki、Fujishima Seitaro、Iwata Satoshi、Umeyama Takashi、Katano Harutaka、Uwamino Yoshifumi、Miyazaki Yoshitsugu、Kamei Katsuhiko、Hasegawa Naoki、Betsuyaku Tomoko
    • Journal Title

      Medicine

      Volume: 98 Issue: 17 Pages: e15264-e15264

    • DOI

      10.1097/md.0000000000015264

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastric mucormycosis complicated by a gastropleural fistula: A case report and review of the literature.2019

    • Author(s)
      Tomohisa Uchida,Momoko Okamoto,Keita Fujikawa,Daisuke Yoshikawa,Akinari Mizokami,Tomo Mihara,Akira Kondo,Kazuo Ohba,Kazuhiro Kurohama,Masahiro Nakashima,Ichiro Sekine,Shigeki Nakamura,Yoshitsugu Miyazaki,Atsushi Kawakami]
    • Journal Title

      Medicine

      Volume: 98 Issue: 48 Pages: e18142-e18142

    • DOI

      10.1097/md.0000000000018142

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The incidence of endophthalmitis or macular involvement and the necessity of a routine ophthalmic examination in patients with candidemia.2019

    • Author(s)
      Ueda T, Takesue Y, Tokimatsu I, Miyazaki T, Nakada-Motokawa N, Nagao M, Nakajima K, Mikamo H, Yamagishi Y, Kasahara K, Yoshihara S, Ukimura A, Yoshida K, Yoshinaga N, Izumi M, Kakeya H, Yamada K, Kawamura H, Endou K, Yamanaka K, Yoshioka M, Amino K, Ikeuchi H, Uchino M, Miyazaki Y.
    • Journal Title

      PLoS One.

      Volume: 14 Issue: 5 Pages: e0216956-e0216956

    • DOI

      10.1371/journal.pone.0216956

    • NAID

      120006719416

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neutrophil-mediated antifungal activity against highly virulent Cryptococcus gattii strain R2652019

    • Author(s)
      Ueno Keigo、Yanagihara Nao、Otani Yoshiko、Shimizu Kiminori、Kinjo Yuki、Miyazaki Yoshitsugu
    • Journal Title

      Medical Mycology

      Volume: 印刷中 Issue: 8 Pages: 1046-1054

    • DOI

      10.1093/mmy/myy153

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of T-2307, a novel arylamidine, against ocular complications of disseminated candidiasis in mice2019

    • Author(s)
      Abe Masahiro、Nakamura Shigeki、Kinjo Yuki、Masuyama Yuka、Mitsuyama Junichi、Kaku Mitsuo、Miyazaki Yoshitsugu
    • Journal Title

      Journal of Antimicrobial Chemotherapy

      Volume: 74 Issue: 5 Pages: 1327-1332

    • DOI

      10.1093/jac/dkz020

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis2018

    • Author(s)
      Ueno Keigo、Urai Makoto、Sadamoto Sota、Shinozaki Minoru、Takatsuka Shogo、Abe Masahiro、Otani Yoshiko、Yanagihara Nao、Shimizu Kiminori、Iwakura Yoichiro、Shibuya Kazutoshi、Miyazaki Yoshitsugu、Kinjo Yuki
    • Journal Title

      Mucosal Immunology

      Volume: 12 Issue: 1 Pages: 265-276

    • DOI

      10.1038/s41385-018-0094-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CRISPR/Cas9 Genome Editing To Demonstrate the Contribution of Cyp51A Gly138Ser to Azole Resistance in Aspergillus fumigatus2018

    • Author(s)
      Umeyama Takashi、Hayashi Yuta、Shimosaka Hisaki、Inukai Tatsuya、Yamagoe Satoshi、Takatsuka Shogo、Hoshino Yasutaka、Nagi Minoru、Nakamura Shigeki、Kamei Katsuhiko、Ogawa Kenji、Miyazaki Yoshitsugu
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 62 Issue: 9

    • DOI

      10.1128/aac.00894-18

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in Ocular Complications Between Candida albicans and Non-albicans Candida Infection Analyzed by Epidemiology and a Mouse Ocular Candidiasis Model2018

    • Author(s)
      Abe Masahiro、Kinjo Yuki、Ueno Keigo、Takatsuka Shogo、Nakamura Shigeki、Ogura Sho、Kimura Muneyoshi、Araoka Hideki、Sadamoto Sota、Shinozaki Minoru、Shibuya Kazutoshi、Yoneyama Akiko、Kaku Mitsuo、Miyazaki Yoshitsugu
    • Journal Title

      Frontiers in Microbiology

      Volume: 9 Pages: 1266-1266

    • DOI

      10.3389/fmicb.2018.02477

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micafungin Breakthrough Fungemia in Patients with Hematological Disorders2018

    • Author(s)
      Kimura Muneyosh, et al
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 62 Issue: 5

    • DOI

      10.1128/aac.02183-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraspecies variation in the efficacy of adjunctive recombinant interferon-γ therapy against cryptococcal meningoencephalitis in mice.2017

    • Author(s)
      Ikeda-Dantsuji Y, Nakamura S, Ohno H, Inukai T, Nagi M, Ueno K, Umeyama T, Kinjo Y, Yamagoe S, Shibuya K, Miyazaki Y
    • Journal Title

      Medical mycology

      Volume: 56 Issue: 3 Pages: 382-386

    • DOI

      10.1093/mmy/myx063

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Giant Dermatophyte Abscess Caused by <I>Trichophyton rubrum</I> in an Immunocompromised Patient2017

    • Author(s)
      1.Toyoki M, Hase M, Hirasawa Y, Umeyama T, Miyazaki Y, Kano R, Sugita T, Hiruma M, Kodama Y, Ikeda S.
    • Journal Title

      Medical Mycology Journal

      Volume: 58 Issue: 2 Pages: E63-E66

    • DOI

      10.3314/mmj.17-00003

    • NAID

      130006906288

    • ISSN
      2185-6486, 2186-165X
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunization with Antigen-Pulsed Dendritic Cells Against Highly Virulent Cryptococcus gattii Infection: Analysis of Cytokine-Producing T Cells2017

    • Author(s)
      Ueno Keigo、Urai Makoto、Takatsuka Shogo、Abe Masahiro、Miyazaki Yoshitsugu、Kinjo Yuki
    • Journal Title

      Methods Mol Biol.

      Volume: 1625 Pages: 327-339

    • DOI

      10.1007/978-1-4939-7104-6_22

    • ISBN
      9781493971039, 9781493971046
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful Treatment of Pulmonary Mucormycosis Caused by Cunninghamella bertholletiae with High-Dose Liposomal Amphotericin B (10 mg/kg/day) Followed by a Lobectomy in Cord Blood Transplant Recipients.2017

    • Author(s)
      Ota H, Yamamoto H, Kimura M, Araoka H, Fujii T, Umeyama T, Ohno H, Miyazaki Y, Kaji D, Taya Y, Nishida A, Ishiwata K, Tsuji M, Takagi S, Asano-Mori Y, Yamamoto G, Uchida N, Izutsu K, Masuoka K, Wake A, Yoneyama A, Makino S, Taniguchi S.
    • Journal Title

      Mycopathologia

      Volume: 61 Issue: 9-10 Pages: 847-853

    • DOI

      10.1007/s11046-017-0149-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a Novel Rhizopus-specific Antigen by Screening with a Signal Sequence Trap and Evaluation as a Possible Diagnostic Marker of Mucormycosis2017

    • Author(s)
      Sato K., Oinuma K., Niki M., Yamagoe S., Miyazaki Y., Asai K., Yamada K., Hirata K., Kaneko Y. and Kakeya H.
    • Journal Title

      Medical Mycology

      Volume: 55 Issue: 7 Pages: 713-719

    • DOI

      10.1093/mmy/myw146

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020099

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mycotic pseudoaneurysm of a pulmonary artery branch caused by Cladosporium2017

    • Author(s)
      Sunagawa Keishin、Uchino Yoshihito、Ishimoto Shinichirou、Nakamura Shigeki、Honma Taku、Nakanishi Yoko、Hatta Yoshihiro、Miyazaki Yoshitsugu、Sakurai Hiroyuki、Hao Hiroyuki、Sugitani Masahiko
    • Journal Title

      Pathology International

      Volume: 68 Issue: 1 Pages: 47-52

    • DOI

      10.1111/pin.12615

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 2016~2018年3年間実施したBiosafety level 3対応が必要な真菌検査について2020

    • Author(s)
      壇辻百合香、星野泰隆、名木 稔、阿部雅弘、上野圭吾、中山靖子、橋本ゆき、東 祥嗣、犬飼達也、高塚翔吾、梅山 隆、山越 智、宮﨑義継
    • Organizer
      第31回日本臨床微生物学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] CRISPR / Cas9 genome editing technology to verify the contribution of known mutations in the cyp51A gene and its promoter to azole resistance in Aspergillus fumigatus.2020

    • Author(s)
      Takashi Umeyama, Tatsuya Inukai, Madoka Tateno, Satoshi Yamagoe, Shogo Takatsuka, Yasutaka Hoshino, Keiko Ishino, Yoshitsugu Miyazaki
    • Organizer
      9th Advanecs Against Aspergillosis and Mucormycosis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hmg1 mutation conferring multi-azole resistance in Aspergillus fumigatus2020

    • Author(s)
      Teppei Arai, Takashi Umeyama, Tatsuya Inukai, Akira Watanabe, Yoshitsugu Miyazaki, Katsuhiko Kamei
    • Organizer
      9th Advanecs Against Aspergillosis and Mucormycosis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 注意すべき糸状菌2020

    • Author(s)
      壇辻百合香、星野泰隆、名木稔、阿部雅広、上野圭吾、中山靖子、橋本ゆき、東祥嗣、犬飼達也、高塚翔吾、梅山隆、山越智、宮崎義継
    • Organizer
      第31回 日本臨床微生物学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Aspergillus fumigatusの血清存在下での増殖機構2020

    • Author(s)
      犬飼達也、梅山 隆、山越 智、宮崎義継
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] クリプトコックス症に対する新規経鼻ワクチンの開発とその作用機構: 免疫賦活性に優れたワクチン株の作製2020

    • Author(s)
      上野 圭吾, 柳原 尚, 清水 公徳, 山越 智, 宮﨑 義継
    • Organizer
      第93回 日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Aspergillus fumigatusの細胞外小胞の解析2019

    • Author(s)
      山越 智、犬飼達也、高塚翔吾、星野泰隆、岡本圭祐、上野圭吾、梅山 隆、宮﨑義継
    • Organizer
      第13回アスペルギルス研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Aspergillus fumigatusアゾール耐性株にみられるCyp51A SNPSのゲノム編集による直接検証2019

    • Author(s)
      梅山 隆、犬飼達也、山越 智、髙塚翔吾、星野泰隆、宮﨑義継
    • Organizer
      第63回日本医真菌学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Aspergillus fumigatus B11b破壊株の増殖を抑制する血清中の成分の同定2019

    • Author(s)
      犬飼達也、星野泰隆、浦井 誠、梅山 隆、高塚翔吾、山越 智、東 祥嗣、阿部雅広、名木 稔、中村茂樹、宮崎義継
    • Organizer
      第63回日本医真菌学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザ続発性肺アスペルギルス症モデルの確立と重症化メカニズムに関する研究2019

    • Author(s)
      高塚翔吾, 林崎浩史, 犬飼達也, 山越智, 梅山隆, 星野泰隆, 上野圭吾, 宮崎義継
    • Organizer
      第63回日本医真菌学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Genome editing technology to elucidate the antifungal resistance mechanisms in filamentous fungi2019

    • Author(s)
      Takashi Umeyama, Tatsuya Inukai, Madoka Tateno, Satoshi Yamagoe, Shogo Takatsuka, Yasutaka Hoshino, Yoshitsugu Miyazaki
    • Organizer
      The Asia Pacific Society for Medical Mycology Congress 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CRISPR/Cas9ゲノム編集技術によるAspergillus fumigatusボリコナゾール耐性変異の検証2018

    • Author(s)
      梅山隆, 犬飼達也, 山越智, 名木稔, 中村茂樹, 小川賢二, 宮﨑義継,
    • Organizer
      第92回日本感染症学会総会・学術講演会 第66回日本化学療法学会学術集会 合同学会
    • Related Report
      2018 Research-status Report
  • [Presentation] アスペルギルス・フミガタスのアゾール系抗真菌薬耐性株の解析2018

    • Author(s)
      星野泰隆, 宮崎義継
    • Organizer
      第62回 日本医真菌学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Aspergillus fumigatusの血清存在下の生育に必須な因子の同定と病原性解析2018

    • Author(s)
      犬飼達也, 梅山 隆, 山越智, 宇田晶彦, 星野泰隆, 高塚翔吾, 阿部雅広, 栃木直文, 篠崎稔, 渋谷和俊, 名木稔, 壇辻百合香, 中村茂樹, 宮崎義継
    • Organizer
      第12回アスペルギルス研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] パラフィン包埋試料を用いた真菌DNA検出状況に関する検討2018

    • Author(s)
      壇辻百合香, 中村茂樹, 東祥嗣, 阿部雅広, 上野圭吾, 梅山隆, 山越智, 宮﨑義継
    • Organizer
      第65回日本化学療法学会東日本支部総会合同学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Mutations in the cyp51A gene of an azole resistant clinical isolate of Aspergillus fumigatus: direct proof using Cas9/CRISPR genome editing2018

    • Author(s)
      T. Umeyama, Y. Hayashi, H. Shimosaka, T. Inukai, S. Yamagoe, M. Nagi, S. Nakamura, K. Ogawa, Y. Miyazaki
    • Organizer
      8th Advanecs Against Aspergillosis
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Uptake of exogenous sterol promotes antifungal resistance in Candida glabrata2018

    • Author(s)
      名木 稔,田辺公一,上野圭吾、犬飼達也、中村茂樹,梅山 隆,山越 智,宮﨑義継
    • Organizer
      第91回 日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Exogenous sterol uptake: A potential cause of azole resistance2018

    • Author(s)
      田辺 公一,名木 稔,犬飼 達也,中山 浩伸,梅山 隆,山越 智,中村 茂樹,宮﨑義継
    • Organizer
      第91回 日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 病原性真菌Cryptococcus gattii の新規感染機構: 莢膜多糖による抗原被覆作用について2018

    • Author(s)
      大谷淑子, 上野圭吾, 柳原 尚, 浦井 誠, 清水公徳, 宮﨑義継, 金城雄樹
    • Organizer
      第91回 日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 好中球は高病原性真菌Cryptococcus gattii の増殖を抑制するか?2018

    • Author(s)
      上野圭吾, 柳原 尚, 大谷淑子, 清水公徳, 宮﨑義継, 金城雄樹
    • Organizer
      第91回 日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 侵襲性真菌症治療の新しい試み2017

    • Author(s)
      宮﨑義継
    • Organizer
      第22回日本神経感染症学会総会・学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 真菌感染症の新しい診断法2017

    • Author(s)
      中村茂樹,中山靖子,壇辻百合香, 名木 稔, 浦井誠, 梅山 隆,山越 智,宮﨑義継
    • Organizer
      第91回 日本感染症学会総会・第65回日本化学療法学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] クリプトコックスの莢膜欠損株は何故病原性が低いのか?: 環境適応と免疫回避機構における莢膜合成の意義2017

    • Author(s)
      上野圭吾, 金城雄樹, 浦井 誠, 宮﨑義継
    • Organizer
      第91回 日本感染症学会総会・第65回日本化学療法学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] クラリスロマイシンによる高病原性Cryptococcus gattiiの莢膜形成抑制作用に関する検討2017

    • Author(s)
      中村茂樹,壇辻百合香, 犬飼達也, 名木 稔, 浦井誠, 梅山 隆,山越 智,宮﨑義継
    • Organizer
      第91回 日本感染症学会総会・第65回日本化学療法学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] アスペルギルス症2017

    • Author(s)
      山越 智, 高塚翔吾, 梅山 隆, 犬飼達也, 名木 稔, 中村茂樹, 宮﨑義継
    • Organizer
      第61回 日本医真菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 病原性および鉄欠乏環境におけるCandida glabrataのマイトファジーの役割2017

    • Author(s)
      名木 稔,田辺公一,上野圭吾,中山浩伸、中村茂樹,梅山 隆,山越 智,宮﨑義継
    • Organizer
      第61回 日本医真菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺常在性記憶型Th17細胞は、高病原性肺クリプトコックス症を制御する2017

    • Author(s)
      上野圭吾, 金城雄樹, 定本聡太, 篠崎 稔, 阿部雅広, 澁谷和俊, 宮﨑義継
    • Organizer
      第61回 日本医真菌学会総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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